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546102-60-7,MFCD08702689
Catalog No.:AA01E4MP

546102-60-7 | Cd4kInhibitor

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1mg
≥90%
in stock  
$166.00   $116.00
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5mg
≥90%
in stock  
$718.00   $502.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E4MP
Chemical Name:
Cd4kInhibitor
CAS Number:
546102-60-7
Molecular Formula:
C20H10BrN3O2
Molecular Weight:
404.2163
MDL Number:
MFCD08702689
SMILES:
Brc1ccc2c(c1)[nH]c1c2c2c(=O)[nH]c(=O)c2c2c1[nH]c1c2cccc1
Properties
Computed Properties
 
Complexity:
657  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
XLogP3:
4.3  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters 20110701

Title: Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication.

Journal: BMC cell biology 20110101

Title: Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells.

Journal: Journal of Cancer 20110101

Title: Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E.

Journal: Cell cycle (Georgetown, Tex.) 20100215

Title: Inhibition of CDK4 impairs proliferation of pancreatic cancer cells and sensitizes towards TRAIL-induced apoptosis via downregulation of survivin.

Journal: International journal of cancer 20070701

Title: Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.

Journal: Journal of medicinal chemistry 20030522

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