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548-04-9,MFCD00016683
Catalog No.:AA00I9PG

548-04-9 | Hypericin

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Purity
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1mg
≥95%
in stock  
$70.00   $49.00
- +
5mg
98% by HPLC
in stock  
$171.00   $120.00
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10mg
98% by HPLC
in stock  
$245.00   $171.00
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25mg
98% by HPLC
in stock  
$446.00   $312.00
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50mg
98% by HPLC
in stock  
$715.00   $500.00
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100mg
98% by HPLC
in stock  
$1,190.00   $833.00
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500mg
98% by HPLC
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$3,699.00   $2,589.00
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1000mg
98% by HPLC
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$5,880.00   $4,116.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I9PG
Chemical Name:
Hypericin
CAS Number:
548-04-9
Molecular Formula:
C30H16O8
Molecular Weight:
504.4432
MDL Number:
MFCD00016683
SMILES:
Oc1cc(C)c2c3c1C(=O)c1c(O)cc(c4c1c3c1c3c2c(C)cc(c3C(=O)c2c1c4c(O)cc2O)O)O
Properties
Computed Properties
 
Complexity:
1090  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
XLogP3:
5.7  

Downstream Synthesis Route

[1]Brockmannetal.[ChemischeBerichte,1957,vol.90,p.2302,2314]

[1]CurrentPatentAssignee:SCHENLEYIND-US2707704,1952,A

[1]Gonçalves,RenatoS.;Rabello,BrunoR.;César,GabrielB.;Pereira,PauloC.S.;Ribeiro,MarcosA.S.;Meurer,EduardoC.;Hioka,Noboru;Nakamura,CelsoV.;Bruschi,MarcosL.;Caetano,Wilker[OrganicProcessResearchandDevelopment,2017,vol.21,#12,p.2025-2031]

[2]Zhang,Ying;Shang,Kun;Wu,Xiaowen;Song,Siyu;Li,Zebo;Pei,Zhichao;Pei,Yuxin[RSCAdvances,2018,vol.8,#39,p.21786-21792]

[3]Locationinpatent:bodytextAigner,Stefan;Falk,Heinz[MonatsheftefurChemie,2008,vol.139,#8,p.991-993]

[4]Falk,Heinz;Schoppel,Gerhard[MonatsheftefurChemie,1992,vol.123,#10,p.931-938]

[5]Qu,Yun;Wang,Xinxin;Pei,Zhichao;Pei,Yuxin[ChemMedChem,2022,vol.17,#2]

[6]Prince,AlfredM.;Pascual,Donna;Meruelo,Daniel;Liebes,Leonard;Mazur,Yehuda;Dubovi,Edward;Mandel,Mathilda;Lavie,Gad[PhotochemistryandPhotobiology,2000,vol.71,#2,p.188-195]

[7]Delaey,ElsM.;Kamuhabwa,AppolinaryR.;Vandenbogaerde,AnnL.;DeWitte,PeterA.[PlantaMedica,1999,vol.65,#8,p.719-722]

[8]Gruszecka-Kowalik,Ewa;Zalkow,LeonH.[OrganicPreparationsandProceduresInternational,2000,vol.32,#1,p.57-61]

[9]Huygens,Ann;Huyghe,Dieter;Bormans,Guy;Verbruggen,Alfons;Kamuhabwa,AppolinaryR.;Roskams,Tania;DeWitte,PeterA.M.[PhotochemistryandPhotobiology,2003,vol.78,#6,p.607-614]

[10]CurrentPatentAssignee:SHANXIJIAHEPHARMACY-CN106588622,2017,ALocationinpatent:Paragraph0034;0038;0042;0046;0050

[1]Falk,Heinz;Schmitzberger,Wolfgang[MonatsheftefurChemie,1993,vol.124,#1,p.77-82]

[1]Falk,Heinz;Schmitzberger,Wolfgang[MonatsheftefurChemie,1993,vol.124,#1,p.77-82]

Literature

Title: Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20141001

Title: Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy.

Journal: Investigational new drugs 20121201

Title: Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells.

Journal: International journal of pharmaceutics 20121015

Title: Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi.

Journal: The protein journal 20121001

Title: Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures.

Journal: Pharmaceutical biology 20121001

Title: Identifying the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) as a potential target for hypericin--a theoretical study.

Journal: Physical chemistry chemical physics : PCCP 20120928

Title: Interventions for mycosis fungoides.

Journal: The Cochrane database of systematic reviews 20120912

Title: Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer.

Journal: Urologic oncology 20120901

Title: Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.

Journal: Phytotherapy research : PTR 20120901

Title: Cell death response of U87 glioma cells on hypericin photoactivation is mediated by dynamics of hypericin subcellular distribution and its aggregation in cellular organelles.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120901

Title: Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species.

Journal: Autophagy 20120901

Title: A basic study on hypericin-PDT in vitro.

Journal: Photodiagnosis and photodynamic therapy 20120901

Title: Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential.

Journal: International journal of cancer 20120715

Title: Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light.

Journal: Journal of applied microbiology 20120601

Title: On the mechanism of Candida spp. photoinactivation by hypericin.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120601

Title: Toward real-time virtual biopsy of oral lesions using confocal laser endomicroscopy interfaced with embedded computing.

Journal: Journal of biomedical optics 20120501

Title: [Rapid cloning and functional characterization of hypericin synthase gene].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120501

Title: St. John's Wort inhibits insulin signaling in murine and human adipocytes.

Journal: Biochimica et biophysica acta 20120401

Title: Hypericin for visualization of high grade gliomas: first clinical experience.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20120401

Title: Rapid aquaporin translocation regulates cellular water flow: mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel.

Journal: The Journal of biological chemistry 20120330

Title: Fluorescence guidance in urologic surgery.

Journal: Current opinion in urology 20120301

Title: Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi.

Journal: Mycorrhiza 20120201

Title: New frontier in hypericin-mediated diagnosis of cancer with current optical technologies.

Journal: Annals of biomedical engineering 20120201

Title: Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin.

Journal: Cancer immunology, immunotherapy : CII 20120201

Title: Between species diversity of Hypericum perforatum and H. maculatum by the content of bioactive compounds.

Journal: Natural product communications 20120201

Title: Evaluation of hypericin-loaded solid lipid nanoparticles: physicochemical properties, photostability and phototoxicity.

Journal: Pharmaceutical development and technology 20120101

Title: Long-term monitoring of live cell proliferation in presence of PVP-Hypericin: a new strategy using ms pulses of LED and the fluorescent dye CFSE.

Journal: Journal of microscopy 20120101

Title: Many stimuli pull the necrotic trigger, an overview.

Journal: Cell death and differentiation 20120101

Title: In vitro fungicidal photodynamic effect of hypericin on Candida species.

Journal: Photochemistry and photobiology 20120101

Title: Molecular response to hypericin-induced photodamage.

Journal: Current medicinal chemistry 20120101

Title: Hypericin-mediated photodynamic antimicrobial effect on clinically isolated pathogens.

Journal: Photochemistry and photobiology 20120101

Title: Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.

Journal: PloS one 20120101

Title: Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.

Journal: Cancer management and research 20120101

Title: Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform.

Journal: Frontiers in microbiology 20120101

Title: An overview of the evidence and mechanisms of herb-drug interactions.

Journal: Frontiers in pharmacology 20120101

Title: Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin.

Journal: Cancer genomics & proteomics 20120101

Title: Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species.

Journal: TheScientificWorldJournal 20120101

Title: Inhibitors of translation targeting eukaryotic translation initiation factor 4A.

Journal: Methods in enzymology 20120101

Title: De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites.

Journal: PloS one 20120101

Title: Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma.

Journal: Photodiagnosis and photodynamic therapy 20111201

Title: Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing.

Journal: Immune network 20111201

Title: A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas.

Journal: Cancer 20111101

Title: Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors.

Journal: Journal of cancer research and clinical oncology 20111101

Title: In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.

Journal: Phytochemistry 20111001

Title: Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells.

Journal: Cell biology international 20110901

Title: A dual-targeting anticancer approach: soil and seed principle.

Journal: Radiology 20110901

Title: Flavonoid glycosides and naphthodianthrones in the sawfly Tenthredo zonula and its host-plants, Hypericum perforatum and H. hirsutum.

Journal: Journal of chemical ecology 20110901

Title: Biphasic dose-response of antioxidants in hypericin-induced photohemolysis.

Journal: Photodiagnosis and photodynamic therapy 20110901

Title: Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model.

Journal: Lasers in surgery and medicine 20110901

Title: [Study on the enzyme extraction process of hypericin by pectinase].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110701

Title: Lipophilic rather than hydrophilic photosensitizers show strong adherence to standard cell culture microplates under cell-free conditions.

Journal: Journal of photochemistry and photobiology. B, Biology 20110602

Title: Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage.

Journal: Journal of cellular and molecular medicine 20110601

Title: Selective enrichment of hypericin in malignant glioma: pioneering in vivo results.

Journal: International journal of oncology 20110501

Title: The possible use of hypericin to overcome drug resistance in cancer treatment.

Journal: Chemico-biological interactions 20110425

Title: Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder.

Journal: Cancer chemotherapy and pharmacology 20110401

Title: Hypericin incorporation and localization in fixed HeLa cells for various conditions of fixation and incubation.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110401

Title: Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110401

Title: Hypericum perforatum for the treatment of premenstrual syndrome.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20110401

Title: On the diffusion of hypericin in dimethylsulfoxide/water mixtures-the effect of aggregation.

Journal: The journal of physical chemistry. B 20110317

Title: Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110301

Title: Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia.

Journal: Natural product research 20110301

Title: Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway.

Journal: PLoS pathogens 20110301

Title: Photodynamic therapy using topically applied hypericin: comparative effect with methyl-aminolevulinic acid on UV induced skin tumours.

Journal: Journal of photochemistry and photobiology. B, Biology 20110207

Title: Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity.

Journal: Natural product research 20110201

Title: Plant-derived bioactive compounds produced by endophytic fungi.

Journal: Mini reviews in medicinal chemistry 20110201

Title: Identification of kinase inhibitors that target transcription initiation by RNA polymerase II.

Journal: Oncotarget 20110201

Title: Targeting transcription through inhibition of TBP.

Journal: Oncotarget 20110201

Title: Pharmacological studies on Hypericum perforatum fractions and constituents.

Journal: Pharmaceutical biology 20110101

Title: The photodynamic effect: the comparison of chemiexcitation by luminol and phthalhydrazide.

Journal: Luminescence : the journal of biological and chemical luminescence 20110101

Title: Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.

Journal: Biochimica et biophysica acta 20110101

Title: Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101

Title: Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Kinetics of hypericin association with low-density lipoproteins.

Journal: Photochemistry and photobiology 20110101

Title: MPEG-hexPLA micelles as novel carriers for hypericin, a fluorescent marker for use in cancer diagnostics.

Journal: Photochemistry and photobiology 20110101

Title: Photoactivated hypericin induces downregulation of HER2 gene expression.

Journal: Radiation research 20110101

Title: Comparison of the endemic Azorean Hypericum foliosum with other Hypericum species: antioxidant activity and phenolic profile.

Journal: Natural product research 20110101

Title: Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice.

Journal: BMC complementary and alternative medicine 20110101

Title: Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L.) grown in controlled environments.

Journal: Photochemistry and photobiology 20110101

Title: Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells.

Journal: Journal of biomedical optics 20110101

Title: The use of endophytes to obtain bioactive compounds and their application in biotransformation process.

Journal: Biotechnology research international 20110101

Title: Design and characterization of protein-quercetin bioactive nanoparticles.

Journal: Journal of nanobiotechnology 20110101

Title: Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo.

Journal: Frontiers in pharmacology 20110101

Title: Antioxidant activity relationship of phenolic compounds in Hypericum perforatum L.

Journal: Chemistry Central journal 20110101

Title: Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents.

Journal: International journal of nanomedicine 20110101

Title: Induction of immune mediators in glioma and prostate cancer cells by non-lethal photodynamic therapy.

Journal: PloS one 20110101

Title: Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene.

Journal: PloS one 20110101

Title: Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy.

Journal: PloS one 20110101

Title: Effects of Hypericum perforatum extract on rat irritable bowel syndrome.

Journal: Pharmacognosy magazine 20110101

Title: Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.

Journal: PloS one 20110101

Title: A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Journal: PloS one 20110101

Title: A high-precision micropipette sensor for cellular-level real-time thermal characterization.

Journal: Sensors (Basel, Switzerland) 20110101

Title: Emerging endoscopic and photodynamic techniques for bladder cancer detection and surveillance.

Journal: TheScientificWorldJournal 20110101

Title: Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A.

Journal: International journal of molecular sciences 20110101

Title: A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasis.

Journal: Journal of the American Academy of Dermatology 20101201

Title: Hyperflav - perspective photosensitizer for PDT: cell studies.

Journal: Experimental oncology 20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Optimization of protein extraction from Hypericum perforatum tissues and immunoblotting detection of Hyp-1 at different stages of leaf development.

Journal: Molecular biotechnology 20101101

Title: Radiation recall with anticancer agents.

Journal: The oncologist 20101101

Title: Screening for in vitro phototoxic activity of methanol extracts of Croton campestris A., Ocimum gratissimum L. & Cordia verbenaceae DC.

Journal: The Indian journal of medical research 20101101

Title: Inhibition characteristics of hypericin on rat small intestine glutathione-S-transferases.

Journal: Chemico-biological interactions 20101006

Title: Interaction between hypericin and hemoglobin.

Journal: Journal of photochemistry and photobiology. B, Biology 20101005

Title: Effects of hypericin on the structure and aggregation properties of β-amyloid peptides.

Journal: European biophysics journal : EBJ 20101001

Title: PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20100924

Title: Comparative in vitro study on the characteristics of different photosensitizers employed in PDT.

Journal: Journal of photochemistry and photobiology. B, Biology 20100902

Title: Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells.

Journal: Lasers in medical science 20100901

Title: Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells.

Journal: The Journal of pharmacology and experimental therapeutics 20100901

Title: Naturally occurring food toxins.

Journal: Toxins 20100901

Title: Small-animal SPECT and SPECT/CT: application in cardiovascular research.

Journal: European journal of nuclear medicine and molecular imaging 20100801

Title: Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport.

Journal: Journal of medicinal food 20100801

Title: TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.

Journal: British journal of cancer 20100727

Title: Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs.

Journal: Evidence-based complementary and alternative medicine : eCAM 20100601

Title: Production of adventitious roots and secondary metabolites by Hypericum perforatum L. in a bioreactor.

Journal: Bioresource technology 20100601

Title: Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy: a case report.

Journal: Photodiagnosis and photodynamic therapy 20100601

Title: Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.

Journal: Natural product communications 20100601

Title: Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).

Journal: Journal of natural products 20100528

Title: Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway.

Journal: European journal of pharmacology 20100525

Title: Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments.

Journal: Chirality 20100515

Title: Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

Title: St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity.

Journal: Biochemical pharmacology 20100501

Title: Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100501

Title: St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier.

Journal: Pharmaceutical research 20100501

Title: Interaction dynamics of hypericin with low-density lipoproteins and U87-MG cells.

Journal: International journal of pharmaceutics 20100415

Title: Anti-influenza virus principles from Muehlenbeckia hastulata.

Journal: Journal of natural medicines 20100401

Title: Hypericin prolongs action potential duration in hippocampal neurons by acting on K+ channels.

Journal: British journal of pharmacology 20100401

Title: Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum.

Journal: Fitoterapia 20100301

Title: The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial.

Journal: CNS drugs 20100301

Title: Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20100301

Title: A semi-quantitative FIA-ESI-MS method for the rapid screening of Hypericum perforatum crude extracts.

Journal: Natural product communications 20100301

Title: Investigations on the in vivo wound healing potential of Hypericum perforatum L.

Journal: Journal of ethnopharmacology 20100203

Title: Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin.

Journal: Journal of structural biology 20100201

Title: A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.

Journal: The journal of pain : official journal of the American Pain Society 20100201

Title: Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells.

Journal: Journal of photochemistry and photobiology. B, Biology 20100121

Title: Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin.

Journal: Phytotherapy research : PTR 20100101

Title: Degradation of HER2 receptor through hypericin-mediated photodynamic therapy.

Journal: Photochemistry and photobiology 20100101

Title: Hypericin hydroquinone: potential as a red-far red photosensitizer?

Journal: Photochemistry and photobiology 20100101

Title: Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

Journal: International journal of cell biology 20100101

Title: Evaluation of hypericin-mediated photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy.

Journal: Journal of biomedical optics 20100101

Title: Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease.

Journal: Molecular neurodegeneration 20100101

Title: The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

Journal: International journal of cell biology 20100101

Title: Hypericins as potential leads for new therapeutics.

Journal: International journal of molecular sciences 20100101

Title: [Absorption and fluorescence spectra of hypericin sodium salt in complexes with albumins].

Journal: Biofizika 20100101

Title: Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice.

Journal: BMC complementary and alternative medicine 20100101

Title: Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes.

Journal: Marine drugs 20100101

Title: NF-κB is not directly responsible for photoresistance induced by fractionated light delivery in HT-29 colon adenocarcinoma cells.

Journal: Photochemistry and photobiology 20100101

Title: Physiological, biochemical and molecular characteristics of cryopreserved Hypericum perforatum L. shoot tips.

Journal: Cryo letters 20100101

Title: Bilateral posterior RION after concomitant radiochemotherapy with temozolomide in a patient with glioblastoma multiforme: a case report.

Journal: BMC cancer 20100101

Title: Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.

Journal: Nutrition journal 20100101

Title: Luteinizing hormone-releasing hormone receptor-mediated delivery of mitoxantrone using LHRH analogs modified with PEGylated liposomes.

Journal: International journal of nanomedicine 20100101

Title: Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption.

Journal: BMC musculoskeletal disorders 20100101

Title: [Controversial interpretations of the Lorsch medical codex].

Journal: Medizinhistorisches Journal 20100101

Title: Effects of Hypericum Perforatum, in a rodent model of periodontitis.

Journal: BMC complementary and alternative medicine 20100101

Title: Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate.

Journal: International journal of molecular sciences 20100101

Title: Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves.

Journal: International journal of molecular sciences 20100101

Title: Determination of total hypericins in St. John's wort and herbal medicinal products.

Journal: Acta poloniae pharmaceutica 20100101

Title: Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stressinduced behavioral and biochemical alteration in male albino mice.

Journal: Pharmacognosy research 20100101

Title: Importance of novel drug delivery systems in herbal medicines.

Journal: Pharmacognosy reviews 20100101

Title: Proliferation of retinal pigment epithelial cells induced by (R,R)-XY-10 and (S,S)-XY-10 and their action mechanisms.

Journal: International journal of ophthalmology 20100101

Title: Matrix-free UV-laser desorption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species.

Journal: The Plant journal : for cell and molecular biology 20091201

Title: Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations.

Journal: The AAPS journal 20091201

Title: Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20091201

Title: Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions.

Journal: British journal of cancer 20091103

Title: The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20091101

Title: Nanovesicles released by Dictyostelium cells: a potential carrier for drug delivery.

Journal: International journal of pharmaceutics 20091001

Title: Comment on 'Hypericin uptake: a prognostic marker for survival in high-grade glioma'.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20091001

Title: Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy.

Journal: Cell biology international 20091001

Title: In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey.

Journal: Oncology reports 20091001

Title: Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin.

Journal: International journal of oncology 20091001

Title: Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis.

Journal: Journal of natural products 20091001

Title: The association between self-reported cataracts and St. John's Wort.

Journal: Current eye research 20091001

Title: Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer.

Journal: Journal of drug targeting 20090901

Title: Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model.

Journal: British journal of cancer 20090818

Title: Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20090801

Title: Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum.

Journal: Phytochemistry 20090701

Title: Photodynamic effect of hypericin in primary cultures of human umbilical endothelial cells and glioma cell lines.

Journal: Phytotherapy research : PTR 20090601

Title: Topic issue on new treatments in bladder cancer.

Journal: World journal of urology 20090601

Title: Molecular imaging of cell death.

Journal: Methods (San Diego, Calif.) 20090601

Title: Lipid-mediated preferential localization of hypericin in lipid membranes.

Journal: Biochimica et biophysica acta 20090601

Title: In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090601

Title: Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.

Journal: Behavioural brain research 20090516

Title: Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC.

Journal: Journal of separation science 20090501

Title: Photosensitized production of singlet oxygen: spatially-resolved optical studies in single cells.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090401

Title: Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes.

Journal: Rapid communications in mass spectrometry : RCM 20090301

Title: Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light.

Journal: Photodiagnosis and photodynamic therapy 20090301

Title: Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress.

Journal: Cell calcium 20090201

Title: Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090201

Title: Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.

Journal: British journal of clinical pharmacology 20090201

Title: Screening of nanoparticulate delivery systems for the photodetection of cancer in a simple and cost-effective model.

Journal: Nanomedicine (London, England) 20090201

Title: Effects of different concentrations of benzylaminopurine on shoot regeneration and hypericin content in Hypericum triquetrifolium Turra.

Journal: Natural product research 20090101

Title: Time-resolved luminescence and singlet oxygen formation after illumination of the hypericin-low-density lipoprotein complex.

Journal: Photochemistry and photobiology 20090101

Title: Fluorescence study on the interaction between hypericin and lens protein 'alpha-crystallin'.

Journal: Photochemistry and photobiology 20090101

Title: Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20090101

Title: The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

Journal: Nuclear receptor signaling 20090101

Title: Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques.

Journal: Journal of biomedical optics 20090101

Title: Role of p38 MAPKs in hypericin photodynamic therapy-induced apoptosis of nasopharyngeal carcinoma cells.

Journal: Photochemistry and photobiology 20090101

Title: Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum.

Journal: Virology journal 20090101

Title: Cationic hypericin derivatives as novel agents with photobactericidal activity: synthesis and photodynamic inactivation of Propionibacterium acnes.

Journal: Photochemistry and photobiology 20090101

Title: Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.

Journal: Natural product research 20090101

Title: The multifaceted photocytotoxic profile of hypericin.

Journal: Molecular pharmaceutics 20090101

Title: LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices.

Journal: Annals of general psychiatry 20090101

Title: Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response.

Journal: Molecular cancer 20090101

Title: PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1.

Journal: Molecular vision 20090101

Title: Photodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancer.

Journal: Head & neck oncology 20090101

Title: Retinal phototoxicity in a novel murine model of intraocular lens implantation.

Journal: Molecular vision 20090101

Title: [Experimental study of vitreoretinal proliferation inhibition by the use of hypericin].

Journal: Arquivos brasileiros de oftalmologia 20090101

Title: Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors.

Journal: Free radical biology & medicine 20081201

Title: Drug interactions with natural products at the blood brain barrier.

Journal: Current drug metabolism 20081201

Title: Molecular mechanisms underlying St. John's wort drug interactions.

Journal: Current drug metabolism 20081201

Title: Variation of hypericins in Hypericum triquetrifolium Turra growing in different locations of Turkey during plant growth.

Journal: Natural product research 20081201

Title: Cytological and biochemical effects of St. John's Wort supplement (a complex mixture of St. John's Wort, Rosemary and Spirulina) on somatic and germ cells of Swiss Albino mice.

Journal: International journal of environmental research and public health 20081201

Title: Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.

Journal: Journal of photochemistry and photobiology. B, Biology 20081113

Title: In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin.

Journal: Oncology reports 20081101

Title: [Studies on the chemical constituents of flowers of Prunus mume].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101

Title: In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study.

Journal: FEBS letters 20081015

Title: Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete.

Journal: Planta medica 20081001

Title: The effect of solution electrolytes on the uptake of photosensitizers by liposomal membranes: a salting-out effect.

Journal: Chemistry and physics of lipids 20080901

Title: Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins.

Journal: The FEBS journal 20080901

Title: Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20080801

Title: Signal interaction between nitric oxide and hydrogen peroxide in heat shock-induced hypericin production of Hypericum perforatum suspension cells.

Journal: Science in China. Series C, Life sciences 20080801

Title: Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells.

Journal: Molecular cancer therapeutics 20080801

Title: Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines.

Journal: Journal of agricultural and food chemistry 20080709

Title: Hypericin uptake: a prognostic marker for survival in high-grade glioma.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20080701

Title: Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial.

Journal: JAMA 20080611

Title: Photodynamic diagnosis in urology: state-of-the-art.

Journal: European urology 20080601

Title: Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. subsp. apollinis (Boiss. & Heldr.) Robson & Strid methanol extract.

Journal: Phytotherapy research : PTR 20080601

Title: Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells.

Journal: Journal of photochemistry and photobiology. B, Biology 20080529

Title: Hypericin-mediated photodynamic therapy of pituitary tumors: preclinical study in a GH4C1 rat tumor model.

Journal: Journal of neuro-oncology 20080501

Title: Hypericum perforatum plant cells reduce Agrobacterium viability during co-cultivation.

Journal: Planta 20080501

Title: Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin.

Journal: The Journal of urology 20080501

Title: Crystallization and preliminary crystallographic studies of Hyp-1, a St John's wort protein implicated in the biosynthesis of hypericin.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20080501

Title: Exploration of the mechanism underlying the tumor necrosis avidity of hypericin.

Journal: Oncology reports 20080401

Title: Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model.

Journal: Oncology reports 20080401

Title: How to make hypericin water-soluble.

Journal: Die Pharmazie 20080401

Title: Molecular pharmacology of adipocyte-secreted autotaxin.

Journal: Chemico-biological interactions 20080327

Title: Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.

Journal: The Journal of biological chemistry 20080321

Title: Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.

Journal: Oncogene 20080320

Title: Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin.

Journal: The British journal of dermatology 20080201

Title: An endophytic fungus from Hypericum perforatum that produces hypericin.

Journal: Journal of natural products 20080201

Title: Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin.

Journal: International journal of molecular sciences 20080201

Title: 1H NMR determination of hypericin and pseudohypericin in complex natural mixtures by the use of strongly deshielded OH groups.

Journal: Analytica chimica acta 20080128

Title: Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.

Journal: Academic radiology 20080101

Title: Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT.

Journal: European heart journal 20080101

Title: High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL.

Journal: Photochemistry and photobiology 20080101

Title: Photosensitizing and radiosensitizing effects of hypericin on human renal carcinoma cells in vitro.

Journal: Photochemistry and photobiology 20080101

Title: Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot study.

Journal: Photochemistry and photobiology 20080101

Title: Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.

Journal: The international journal of biochemistry & cell biology 20080101

Title: Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide.

Journal: BMC cancer 20080101

Title: Radiation recall dermatitis: case report and review of the literature.

Journal: Current oncology (Toronto, Ont.) 20080101

Title: Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy.

Journal: Molecular vision 20080101

Title: Quantum dots in axillary lymph node mapping: biodistribution study in healthy mice.

Journal: BMC cancer 20080101

Title: Accumulation and interaction of hypericin in low-density lipoprotein--a photophysical study.

Journal: Photochemistry and photobiology 20080101

Title: Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy.

Journal: Molecular cancer 20080101

Title: Potentiation of the photodynamic action of hypericin.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20080101

Title: Chemical markers for the quality control of herbal medicines: an overview.

Journal: Chinese medicine 20080101

Title: Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition.

Journal: Photochemistry and photobiology 20080101

Title: Fluorescence diagnosis of bladder cancer with new water soluble hypericin bound to polyvinylpyrrolidone: PVP-hypericin.

Journal: Photochemistry and photobiology 20080101

Title: Clinically relevant safety issues associated with St. John's wort product labels.

Journal: BMC complementary and alternative medicine 20080101

Title: Self-help interventions for depressive disorders and depressive symptoms: a systematic review.

Journal: Annals of general psychiatry 20080101

Title: Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells.

Journal: Anticancer research 20080101

Title: The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands.

Journal: BMC evolutionary biology 20080101

Title: Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ.

Journal: Journal of biomedical optics 20080101

Title: Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells.

Journal: BMC cancer 20080101

Title: Influence of application and formulation factors on the penetration of hypericin in normal mouse skin and UV induced skin tumors.

Journal: Journal of photochemistry and photobiology. B, Biology 20071214

Title: Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20071201

Title: Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.

Journal: BJU international 20071101

Title: Effect of hypericin-mediated photodynamic therapy on the expression of vascular endothelial growth factor in human nasopharyngeal carcinoma.

Journal: International journal of molecular medicine 20071001

Title: Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy.

Journal: Technology in cancer research & treatment 20071001

Title: Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete.

Journal: Planta medica 20071001

Title: Fluorescence detection of bladder cancer using urine cytology.

Journal: International journal of oncology 20070901

Title: Recent developments in fluorescence cystoscopy: do novel agents bring a benefit?

Journal: Current opinion in urology 20070901

Title: Herbal medicine in the treatment of mental disorders.

Journal: Psychiatria Danubina 20070901

Title: Herbal medicines: can we do without pharmacologist?

Journal: Evidence-based complementary and alternative medicine : eCAM 20070901

Title: Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells.

Journal: British journal of cancer 20070820

Title: Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070801

Title: Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.

Journal: Journal of agricultural and food chemistry 20070725

Title: Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20070701

Title: Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice.

Journal: Archives of pathology & laboratory medicine 20070701

Title: CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells.

Journal: British journal of cancer 20070618

Title: Hyperforin accumulates in the translucent glands of Hypericum perforatum.

Journal: Annals of botany 20070601

Title: Antimicrobial activity of seven hypericum entities from central Italy.

Journal: Planta medica 20070601

Title: Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.

Journal: The Journal of pharmacy and pharmacology 20070501

Title: [Morphological identification of 20 medicinal species in Hypericum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070501

Title: Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms.

Journal: Yonsei medical journal 20070430

Title: Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy.

Journal: Apoptosis : an international journal on programmed cell death 20070401

Title: Hypericin activates L-type Ca2+ channels in cardiac myocytes.

Journal: Journal of natural products 20070401

Title: Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells.

Journal: Cellular and molecular life sciences : CMLS 20070401

Title: [Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20070401

Title: Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model.

Journal: Journal of photochemistry and photobiology. B, Biology 20070301

Title: In vitro photodynamic therapy of childhood rhabdomyosarcoma.

Journal: International journal of oncology 20070301

Title: Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines.

Journal: International journal of oncology 20070301

Title: Expression of the hyp-1 gene in early stages of development of Hypericum perforatum L.

Journal: Plant cell reports 20070201

Title: Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20070201

Title: Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats.

Journal: Phytotherapy research : PTR 20070201

Title: In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems.

Journal: International journal of oncology 20070201

Title: A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.

Journal: Current drug metabolism 20070201

Title: [The development of secondary cells in the callus of Hypericum perforatum L. and hypericins accumulation].

Journal: Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20070201

Title: The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial 'side effect' of an OTC antidepressant drug?

Journal: Free radical research 20070201

Title: Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead.

Journal: European journal of pharmacology 20070112

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: Variation in the content of hypericins in four generations of seed progeny of Hypericum perforatum somaclones.

Journal: Journal of plant research 20070101

Title: The production of hypericins in two selected Hypericum perforatum shoot cultures is related to differences in black gland structure.

Journal: Plant physiology and biochemistry : PPB 20070101

Title: Ethnoveterinary medicines used for ruminants in British Columbia, Canada.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment.

Journal: PloS one 20070101

Title: Simultaneous determination of total hypericin and hyperforin in St. John's wort extracts by HPLC with electrochemical detection.

Journal: Phytochemical analysis : PCA 20070101

Title: Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor.

Journal: Contrast media & molecular imaging 20070101

Title: Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.

Journal: Photochemistry and photobiology 20070101

Title: Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma.

Journal: Folia histochemica et cytobiologica 20070101

Title: St. John's wort: role of active compounds for its mechanism of action and efficacy.

Journal: Wiener medizinische Wochenschrift (1946) 20070101

Title: Photophysics and multifunctionality of hypericin-like pigments in heterotrich ciliates: a phylogenetic perspective.

Journal: Photochemistry and photobiology 20070101

Title: Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells.

Journal: Photochemistry and photobiology 20070101

Title: 'Competitive quenching': a mechanism by which perihydroxylated perylenequinone photosensitizers can prevent adverse phototoxic damage caused by verteporfin during photodynamic therapy.

Journal: Photochemistry and photobiology 20070101

Title: A quantitative synthesis of the medicinal ethnobotany of the Malinké of Mali and the Asháninka of Peru, with a new theoretical framework.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: Virucidal agents in the eve of manorapid synergy.

Journal: GMS Krankenhaushygiene interdisziplinar 20070101

Title: Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer.

Journal: International journal of pharmaceutics 20061201

Title: Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice.

Journal: Planta medica 20061201

Title: Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin.

Journal: Oncology reports 20061201

Title: Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201

Title: Comparative analysis of naphthodianthrone and phloroglucine derivatives in St. John's Wort extracts by near infrared spectroscopy, high-performance liquid chromatography and capillary electrophoresis.

Journal: Analytica chimica acta 20061124

Title: Reduction in hypericin-induced phototoxicity by Hypericum perforatum extracts and pure compounds.

Journal: Journal of photochemistry and photobiology. B, Biology 20061101

Title: Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20061101

Title: Plant-environment interactions: Accumulation of hypericin in dark glands of Hypericum perforatum.

Journal: Annals of botany 20061001

Title: Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial.

Journal: Journal of clinical pharmacology 20061001

Title: [Sunburn -- or yet not?].

Journal: MMW Fortschritte der Medizin 20060921

Title: Delivery of hypericin for photodynamic applications.

Journal: Cancer letters 20060908

Title: Fluorescence cystoscopy: is it ready for use in routine clinical practice?

Journal: Current opinion in urology 20060901

Title: Hypericin lights up the way for the potential treatment of nasopharyngeal cancer by photodynamic therapy.

Journal: Current clinical pharmacology 20060901

Title: Comparative phytochemical and antimicrobial investigations of Hypericum perforatum L. subsp. perforatum and H. perforatum subsp. angustifolium (DC.) Gaudin.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20060901

Title: Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.

Journal: Journal of photochemistry and photobiology. B, Biology 20060801

Title: Intracellular chemiluminescence activates targeted photodynamic destruction of leukaemic cells.

Journal: British journal of cancer 20060717

Title: Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model.

Journal: Cancer letters 20060708

Title: p53 Status does not affect photodynamic cell killing induced by hypericin.

Journal: Cancer chemotherapy and pharmacology 20060701

Title: Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?

Journal: Planta medica 20060601

Title: Stem cells and CAM.

Journal: Evidence-based complementary and alternative medicine : eCAM 20060601

Title: Hypericin and pulsed laser therapy of squamous cell cancer in vitro.

Journal: Photomedicine and laser surgery 20060601

Title: Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort.

Journal: Journal of chromatography. A 20060519

Title: Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin.

Journal: Archives of biochemistry and biophysics 20060515

Title: First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent.

Journal: European journal of nuclear medicine and molecular imaging 20060501

Title: [Evaluation of preparing process of extract of hypericum perforatum using HPLC fingerprint analysis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

Title: Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer.

Journal: Cancer letters 20060428

Title: Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds.

Journal: Journal of agricultural and food chemistry 20060419

Title: Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.

Journal: Neurosurgical focus 20060415

Title: Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.

Journal: Journal of agricultural and food chemistry 20060405

Title: Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060401

Title: Induction of hypericins in Hypericum perforatum in response to chromium.

Journal: Fitoterapia 20060401

Title: Maristentorin, a novel pigment from the positively phototactic marine ciliate Maristentor dinoferus, is structurally related to hypericin and stentorin.

Journal: The journal of physical chemistry. B 20060330

Title: MDR- and CYP3A4-mediated drug-herbal interactions.

Journal: Life sciences 20060327

Title: Anion of hypericin is crucial to understanding the photosensitive features of the pigment.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia--a double-blind placebo-controlled study.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060301

Title: Genetic and biochemical analysis of Hypericum perforatum L. plants regenerated after cryopreservation.

Journal: Plant cell reports 20060301

Title: The impact of aggregation on the biodistribution of hypericin.

Journal: International journal of oncology 20060301

Title: Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin.

Journal: International journal of oncology 20060301

Title: Phytochemical analysis of nine Hypericum L. species from Serbia and the F.Y.R. Macedonia.

Journal: Die Pharmazie 20060301

Title: Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids.

Journal: Proceedings. Biological sciences 20060222

Title: Photophysical properties of Hypericum perforatum L. extracts--novel photosensitizers for PDT.

Journal: Journal of photochemistry and photobiology. B, Biology 20060201

Title: Hypericin-photodynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT.

Journal: Journal of photochemistry and photobiology. B, Biology 20060102

Title: Phytochemical analysis and genetic characterization of six Hypericum species from Serbia.

Journal: Phytochemistry 20060101

Title: The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose.

Journal: European journal of clinical pharmacology 20060101

Title: Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells.

Journal: Photochemistry and photobiology 20060101

Title: Hypericin-enhanced argon laser photocoagulation for subfoveal choroidal neovascular membrane in age-related macular degeneration: a pilot study.

Journal: European journal of ophthalmology 20060101

Title: St. John's wort does not interfere with therapeutic drug monitoring of 12 commonly monitored drugs using immunoassays.

Journal: Journal of clinical laboratory analysis 20060101

Title: Characterization of apoptosis induced by photodynamic treatment with hypericin in A431 human epidermoid carcinoma cells.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20060101

Title: Perylenequinones in photodynamic therapy: cellular versus vascular response.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20060101

Title: Investigation of the effect on photosensitivity following multiple oral dosing of two different hypericum extracts in healthy men.

Journal: Arzneimittel-Forschung 20060101

Title: Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.

Journal: Clinical pharmacokinetics 20060101

Title: About the cover: St. John's wort.

Journal: Journal of the Society for Integrative Oncology 20060101

Title: Hypericin-induced photocytotoxicity is connected with G2/M arrest in HT-29 and S-phase arrest in U937 cells.

Journal: Photochemistry and photobiology 20060101

Title: A high-performance liquid chromatography with electrochemical detection for the determination of total hypericin in extracts of St. John's Wort.

Journal: Phytochemical analysis : PCA 20060101

Title: Evaluation of firefly luciferase bioluminescence mediated photodynamic toxicity in cancer cells.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20060101

Title: Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298].

Journal: BMC medicine 20060101

Title: Mitochondria are a primary target of hypericin phototoxicity: synergy of intracellular calcium mobilisation in cell killing.

Journal: The international journal of biochemistry & cell biology 20060101

Title: Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers.

Journal: BMC clinical pharmacology 20060101

Title: 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'.

Journal: Cancer cell international 20060101

Title: Cellular mechanisms and prospective applications of hypericin in photodynamic therapy.

Journal: Current medicinal chemistry 20060101

Title: Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy -- case report and review of literature.

Journal: Radiation oncology (London, England) 20060101

Title: Photodynamic therapy and tumor imaging of hypericin-treated squamous cell carcinoma.

Journal: World journal of surgical oncology 20060101

Title: [The influence of some elicitors on growth and morphogenesis of Hypericum perforatum callus cultures].

Journal: Ontogenez 20060101

Title: Dietary supplements and sports performance: herbals.

Journal: Journal of the International Society of Sports Nutrition 20060101

Title: Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models.

Journal: Cancer chemotherapy and pharmacology 20051201

Title: Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.

Journal: Bioorganic & medicinal chemistry 20051201

Title: Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro.

Journal: International journal of oncology 20051201

Title: Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma.

Journal: International journal of molecular medicine 20051201

Title: Can St John's wort (hypericin) ingestion enhance the erythemal response during high-dose ultraviolet A1 therapy?

Journal: The British journal of dermatology 20051201

Title: St. John's wort.

Journal: American family physician 20051201

Title: Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.

Journal: The Journal of pharmacy and pharmacology 20051201

Title: Antidepressant-like components of Hypericum perforatum extracts: an overview of their pharmacokinetics and metabolism.

Journal: Current drug metabolism 20051201

Title: [Effects of hypericin associated with radiotherapy on human laryngeal squamous cell carcinoma strain Hep-2].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20051201

Title: Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy.

Journal: Biochemical and biophysical research communications 20051125

Title: Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography.

Journal: Journal of chromatography. A 20051104

Title: Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo.

Journal: International journal of molecular medicine 20051101

Title: Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.

Journal: The journal of medical investigation : JMI 20051101

Title: 25 years of natural product R&D with New South Wales agriculture.

Journal: Molecules (Basel, Switzerland) 20051031

Title: Interaction of glutathione S-transferase with hypericin: A photophysical study.

Journal: The journal of physical chemistry. B 20051020

Title: Nitric oxide mediates the fungal elicitor-induced hypericin production of Hypericum perforatum cell suspension cultures through a jasmonic-acid-dependent signal pathway.

Journal: Plant physiology 20051001

Title: Content analysis and stability evaluation of selected commercial preparations of St. John's wort.

Journal: Drug development and industrial pharmacy 20051001

Title: Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy.

Journal: Toxicology letters 20050915

Title: Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050901

Title: Potential for interaction of kava and St. John's wort with drugs.

Journal: Journal of ethnopharmacology 20050822

Title: Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopy.

Journal: BJU international 20050801

Title: Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells.

Journal: The Journal of urology 20050701

Title: The role of photodynamic diagnosis in the contemporary management of superficial bladder cancer.

Journal: BJU international 20050701

Title: Structure-activity relationships of dengue antiviral polycyclic quinones.

Journal: The Southeast Asian journal of tropical medicine and public health 20050701

Title: Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation.

Journal: International journal of oncology 20050601

Title: Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility.

Journal: The Journal of urology 20050601

Title: Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma?

Journal: BJU international 20050601

Title: Hypericin in the dark inhibits key steps of angiogenesis in vitro.

Journal: European journal of pharmacology 20050601

Title: Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment.

Journal: Biological & pharmaceutical bulletin 20050601

Title: Identification and quantification of hypericin and pseudohypericin in different Hypericum perforatum L. in vitro cultures.

Journal: Plant physiology and biochemistry : PPB 20050601

Title: Hypericin-an inhibitor of proteasome function.

Journal: Cancer chemotherapy and pharmacology 20050501

Title: Elucidation of the tumoritropic principle of hypericin.

Journal: British journal of cancer 20050425

Title: Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.

Journal: The Journal of biological chemistry 20050408

Title: Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050401

Title: Comparative chemical composition and variability of biological activity of methanolic extracts from Hypericum perforatum L.

Journal: Natural product research 20050401

Title: Stability of different formulations and ion pairs of hypericin.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050401

Title: Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050401

Title: No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract.

Journal: Planta medica 20050401

Title: Raman spectroscopic study on structure of human immunodeficiency virus (HIV) and hypericin-induced photosensitive damage of HIV.

Journal: Science in China. Series C, Life sciences 20050401

Title: Competitive quenching: a possible novel approach in protecting RPE cells from damage during PDT.

Journal: Current eye research 20050401

Title: St John's wort (Hypericum perforatum) diminishes cognitive impairment caused by the chronic restraint stress in rats.

Journal: Pharmacological research 20050301

Title: Herbal drug quality and phytochemical composition of Hypericum perforatum L. affected by ash yellows phytoplasma infection.

Journal: Journal of agricultural and food chemistry 20050223

Title: In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder.

Journal: BJU international 20050201

Title: [Effects of hypericin associated with light irradiation on human laryngeal squamous cell carcinoma strain Hep-2].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20050201

Title: The separation of hypericin's enantiomers and their photophysics in chiral environments.

Journal: Photochemistry and photobiology 20050101

Title: Hypericin--the facts about a controversial agent.

Journal: Current pharmaceutical design 20050101

Title: Time-resolved microspectrofluorimetry and fluorescence lifetime imaging of hypericin in human retinal pigment epithelial cells.

Journal: Photochemistry and photobiology 20050101

Title: Novel methyl helianthrones as photosensitizers: synthesis and biological evaluation.

Journal: Photochemistry and photobiology 20050101

Title: Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet.

Journal: Arzneimittel-Forschung 20050101

Title: Fluorescence cystoscopy in the management of bladder cancer: a help for the urologist!

Journal: Urologia internationalis 20050101

Title: The inhibition of CA2+ influx induced by hypericin in cultured human retinal pigment epithelial cells analyzed by confocal imaging.

Journal: Ophthalmic research 20050101

Title: [Enhancement of hypericin production and cell growth of Hypericum perforatum L. suspension cultures by nitric oxide].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20050101

Title: Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity.

Journal: Photochemistry and photobiology 20050101

Title: Fluorescence spectroscopic study of hypericin-photosensitized oxidation of low-density lipoproteins.

Journal: Photochemistry and photobiology 20050101

Title: Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.

Journal: Neoplasma 20050101

Title: Anti-angiogenic activities of hypericin in vivo: potential for ophthalmologic applications.

Journal: Angiogenesis 20050101

Title: Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.

Journal: Arzneimittel-Forschung 20050101

Title: Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort.

Journal: Plant physiology and biochemistry : PPB 20050101

Title: Hypericin-mediated photocytotoxic effect on HT-29 adenocarcinoma cells is reduced by light fractionation with longer dark pause between two unequal light doses.

Journal: Photochemistry and photobiology 20050101

Title: Comparison of extraction techniques for extraction of bioactive molecules from Hypericum perforatum L. plant.

Journal: Journal of chromatographic science 20050101

Title: Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure.

Journal: Journal of AOAC International 20050101

Title: The action of photosensitizers and serum in a bactericidal process. II. The effects of dyes: hypericin, eosin Y and saphranine O.

Journal: Polish journal of microbiology 20050101

Title: Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

Title: Separation methods of quinonoid constituents of plants used in Oriental traditional medicines.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041205

Title: The significance of 'nonsignificance' in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20041201

Title: Impact of cytochrome P-450 inhibition by cimetidine and induction by carbamazepine on the kinetics of hypericin and pseudohypericin in healthy volunteers.

Journal: European journal of clinical pharmacology 20041101

Title: Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans.

Journal: Clinical pharmacology and therapeutics 20041101

Title: Reassessment of the toxicity of Hypericum perforatum (St John's wort) for cattle.

Journal: Australian veterinary journal 20041101

Title: A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin.

Journal: Biochemistry 20041012

Title: Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage.

Journal: Journal of agricultural and food chemistry 20041006

Title: Undeclared exposure to St. John's Wort in hospitalized patients.

Journal: British journal of clinical pharmacology 20041001

Title: Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones.

Journal: International journal of oncology 20041001

Title: Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis.

Journal: The Plant journal : for cell and molecular biology 20041001

Title: Flavonoids of St. John's Wort reduce HPA axis function in the rat.

Journal: Planta medica 20041001

Title: Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst.

Journal: Free radical research 20041001

Title: Antimetastatic activity of the photodynamic agent hypericin in the dark.

Journal: International journal of cancer 20040910

Title: Fluorescence cystoscopy and bladder surveillance.

Journal: Current opinion in urology 20040901

Title: Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20040801

Title: The antidepressant mechanism of Hypericum perforatum.

Journal: Life sciences 20040716

Title: Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.

Journal: Urology 20040701

Title: The antidepressant activity of Hypericum perforatum L. measured by two experimental methods on mice.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20040601

Title: Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501

Title: How effective is St John's wort? The evidence revisited.

Journal: The Journal of clinical psychiatry 20040501

Title: Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells.

Journal: Cancer letters 20040430

Title: Determination of hypericin content in Hypericum triquetrifolium Turra (Hypericaceae) growing wild in Jordan.

Journal: Natural product research 20040401

Title: Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin.

Journal: International journal of oncology 20040301

Title: Extracts from St John's Wort and their antimicrobial activity.

Journal: Phytotherapy research : PTR 20040301

Title: The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum).

Journal: Biotechnology and applied biochemistry 20040201

Title: Detection of hypericins in the 'red glands' of Hypericum elodes by ESI-MS/MS.

Journal: Phytochemistry 20040201

Title: Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex.

Journal: Life sciences 20040109

Title: Commercially available Hypericum perforatum extracts do not decrease immobility of rats in the forced swimming test.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040101

Title: Flow injection analysis mass spectrometry, a tool to investigate the problems in the quantitative analysis of hypericin using reversed-phase high-performance liquid chromatography.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin.

Journal: Phytotherapy research : PTR 20040101

Title: Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.

Journal: The Journal of pharmacy and pharmacology 20040101

Title: Efficacy of quality criteria to identify potentially harmful information: a cross-sectional survey of complementary and alternative medicine web sites.

Journal: Journal of medical Internet research 20040101

Title: In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity.

Journal: American journal of therapeutics 20040101

Title: [The influence of extraction method on the quality of the liquid extract of St John's wort].

Journal: Medicina (Kaunas, Lithuania) 20040101

Title: Drug interactions with St John's wort : mechanisms and clinical implications.

Journal: Drug safety 20040101

Title: Liquid chromatographic determination of St. John's wort components in functional foods.

Journal: Journal of AOAC International 20040101

Title: [Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method].

Journal: Medicina (Kaunas, Lithuania) 20040101

Title: Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes.

Journal: Photochemistry and photobiology 20040101

Title: Lens alpha-crystallin and hypericin: a photophysical mechanism explains observed lens.

Journal: Photochemistry and photobiology 20040101

Title: Structural requirements for efficient cellular photoprotection by carotenoid derivatives.

Journal: Photochemistry and photobiology 20040101

Title: Phototoxicity in human lens epithelial cells promoted by St. John's Wort.

Journal: Photochemistry and photobiology 20040101

Title: Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.

Journal: The Journal of biological chemistry 20031226

Title: Photodynamic effect of hypericin and a water-soluble derivative on isolated crayfish neuron and surrounding glial cells.

Journal: Journal of photochemistry and photobiology. B, Biology 20031205

Title: Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031201

Title: Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin.

Journal: International journal of oncology 20031201

Title: Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.

Journal: Cancer research 20031201

Title: Accumulation and photocytotoxicity of hypericin and analogs in two- and three-dimensional cultures of transitional cell carcinoma cells.

Journal: Photochemistry and photobiology 20031201

Title: Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores.

Journal: Journal of chemical ecology 20031201

Title: St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1.

Journal: Cancer research 20031115

Title: Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin.

Journal: International journal of cancer 20031110

Title: Hypericin-mediated photodynamic therapy induces lipid peroxidation and necrosis in nasopharyngeal cancer.

Journal: International journal of oncology 20031101

Title: Photodynamic therapy of transitional cell carcinoma multicellular tumor spheroids with hypericin.

Journal: International journal of oncology 20031101

Title: Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.

Journal: Pharmacopsychiatry 20031101

Title: [Influence of luyoutal on serum cytokines in patients with depression].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031101

Title: Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers.

Journal: Planta medica 20031101

Title: [Determining the quantity of hypericin in medicinal materials and asepsis seedings of Hypericum perforatum by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031101

Title: Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers.

Journal: Biochemical pharmacology 20031015

Title: [Fluorescence technique on diagnosis of urinary bladder carcinoma].

Journal: Zhonghua yi xue za zhi 20031010

Title: Macro-microscopic fluorescence of human bladder cancer using hypericin fluorescence cystoscopy and laser confocal microscopy.

Journal: International journal of oncology 20031001

Title: Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.

Journal: Protein science : a publication of the Protein Society 20031001

Title: Morphological and molecular phylogenetic studies in South American Cortinarius species.

Journal: Mycological research 20031001

Title: [Effect of factors on callus biomass and synthetic mass of hypericin in Hypericum perforatum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031001

Title: Potentiation of photodynamic therapy with hypericin by mitomycin C in the radiation-induced fibrosarcoma-1 mouse tumor model.

Journal: Photochemistry and photobiology 20030901

Title: Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's wort (Hypericum perforatum L.).

Journal: The Journal of biological chemistry 20030822

Title: Comparison of hexamethylhypericin and tetrabromohypericin to hypericin for their in vivo efficacy as PDT tools.

Journal: International journal of oncology 20030801

Title: The effect of shade, shearing and wool type in the protection of Merino sheep from Hypericum perforatum (St John's wort) poisoning.

Journal: Australian veterinary journal 20030801

Title: Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours.

Journal: British journal of cancer 20030721

Title: Isolation and characterization of antioxidant phenolic compounds from the aerial parts of Hypericum hyssopifolium L. by activity-guided fractionation.

Journal: Journal of ethnopharmacology 20030701

Title: Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030701

Title: Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens.

Journal: Photochemistry and photobiology 20030701

Title: Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.

Journal: Cancer letters 20030630

Title: Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.

Journal: Life sciences 20030620

Title: Mechanisms of action of phenanthroperylenequinones in photodynamic therapy (review).

Journal: International journal of oncology 20030601

Title: Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells.

Journal: International journal of colorectal disease 20030501

Title: Biodistribution and photodynamic therapy with hypericin in a human NPC murine tumor model.

Journal: International journal of oncology 20030501

Title: Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.

Journal: Cancer 20030501

Title: Photosensitized structural modifications of the lens protein alpha-crystallin: do all modifications impair chaperone-like activity?

Journal: Photochemistry and photobiology 20030501

Title: Nitric oxide mediated photo-induced cell death in human malignant cells.

Journal: International journal of oncology 20030401

Title: Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation.

Journal: International journal of oncology 20030401

Title: [Methyl-D3]2hypericin as internal standard for quantification in human plasma.

Journal: Analytical and bioanalytical chemistry 20030301

Title: Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats.

Journal: Planta medica 20030301

Title: Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems.

Journal: Die Pharmazie 20030301

Title: Use of an on-line, precolumn photochemical reactor in high-performance liquid chromatography of naphthodianthrones in Hypericum perforatum preparations.

Journal: Journal of chromatography. A 20030214

Title: Chemical and photochemical electron transfer of new helianthrone derivatives: aspects of their photodynamic activity.

Journal: Journal of the American Chemical Society 20030205

Title: Effect of oral administration ofHypericum perforatum extract (St. John's Wort) on skin erythema and pigmentation induced by UVB, UVA, visible light and solar simulated radiation.

Journal: Phytotherapy research : PTR 20030201

Title: Antagonist effect of pseudohypericin at CRF1 receptors.

Journal: European journal of pharmacology 20030105

Title: Clinic at the health food store? Employee recommendations and product analysis.

Journal: Pharmacotherapy 20030101

Title: [Dangerous interaction of St. John's wort with chemotherapy?].

Journal: Pharmazie in unserer Zeit 20030101

Title: [Formulation of St. John's wort extract. A medicinal obstacle course].

Journal: Pharmazie in unserer Zeit 20030101

Title: Photodynamic inactivation of isolated crayfish neuron requires protein kinase C, PI 3-kinase and Ca2+.

Journal: Journal of photochemistry and photobiology. B, Biology 20030101

Title: Does solvent influence the ground-state tautomeric population of hypericin?

Journal: Photochemistry and photobiology 20030101

Title: Hypericin as novel and promising photodynamic therapy tool: studies on intracellular accumulation capacity and growth inhibition efficiency.

Journal: Medicina (Kaunas, Lithuania) 20030101

Title: Analysis of the hypericin and pseudohypericin content of commercially available St John's Wort preparations.

Journal: The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20030101

Title: Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts.

Journal: Phytochemical analysis : PCA 20030101

Title: An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem).

Journal: Planta medica 20021201

Title: Mood-enhancing antidepressant St. John's wort inhibits the activation of human immunodeficiency virus gene expression by ultraviolet light.

Journal: IUBMB life 20021201

Title: [Effects of hypericin on traumatic proliferative vitreoretinopathy in rabbits].

Journal: Yan ke xue bao = Eye science 20021201

Title: Fluorescence detection of bladder cancer: a review.

Journal: European urology 20021101

Title: Antivascular tumor eradication by hypericin-mediated photodynamic therapy.

Journal: Photochemistry and photobiology 20021101

Title: Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches.

Journal: Pharmaceutical development and technology 20021101

Title: Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis.

Journal: The Journal of biological chemistry 20021004

Title: MEK and ERK inhibitors enhance the anti-proliferative effect of interferon-alpha2b.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

Title: Photodynamic action of some sensitizers by photooxidation of luminol.

Journal: Die Naturwissenschaften 20021001

Title: Antioxidant activity of methanolic extract of Hypericum triquetrifolium Turra aerial part.

Journal: Fitoterapia 20021001

Title: Long term administration of Hypericum perforatum improves spatial learning and memory in the water maze.

Journal: Biological & pharmaceutical bulletin 20021001

Title: Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020925

Title: Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells.

Journal: International journal of oncology 20020901

Title: The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men.

Journal: British journal of clinical pharmacology 20020901

Title: Photobleaching of hypericin bound to human serum albumin, cultured adenocarcinoma cells and nude mice skin.

Journal: Photochemistry and photobiology 20020901

Title: Wavelength-dependent properties of photodynamic therapy using hypericin in vitro and in an animal model.

Journal: Photochemistry and photobiology 20020901

Title: Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.

Journal: The Journal of urology 20020801

Title: Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?

Journal: Protein science : a publication of the Protein Society 20020801

Title: Toward the molecular flashlight: preparation, properties, and photophysics of a hypericin-luciferin tethered molecule.

Journal: Photochemistry and photobiology 20020801

Title: Solubility of hypericin in methanol and methanol-pyridine.

Journal: Die Pharmazie 20020801

Title: Relative quantification of mRNA levels in Jurkat T cells with RT-real time-PCR (RT-rt-PCR): new possibilities for the screening of anti-inflammatory and cytotoxic compounds.

Journal: Pharmaceutical research 20020801

Title: Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy.

Journal: International journal of molecular medicine 20020701

Title: Identification of active antiviral compounds against a New York isolate of West Nile virus.

Journal: Antiviral research 20020701

Title: Effect of acetazolamide on hypericin photocytotoxicity.

Journal: Planta medica 20020701

Title: [Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects].

Journal: Der Nervenarzt 20020701

Title: The correlation between hydrophilicity of hypericins and helianthrone: internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20020701

Title: St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020601

Title: Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells.

Journal: International journal of molecular medicine 20020601

Title: Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort).

Journal: Phytochemistry 20020601

Title: Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide.

Journal: International journal of molecular medicine 20020501

Title: Hypericin-based fluorescence diagnosis of bladder carcinoma.

Journal: BJU international 20020501

Title: Aqueous ethanolic extract of St. John's wort (Hypericum perforatum L.) induces growth inhibition and apoptosis in human malignant cells in vitro.

Journal: Die Pharmazie 20020501

Title: [St. John's wort (Hypericum perforatum L.). A plant with relevance for dermatology].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20020501

Title: Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus.

Journal: Brain research 20020315

Title: Determining hyperforin and hypericin content in eight brands of St. John's wort.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020315

Title: Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.

Journal: International journal of cancer 20020310

Title: Hypericin in cancer treatment: more light on the way.

Journal: The international journal of biochemistry & cell biology 20020301

Title: The separation of hypericine and pseudohypericine from Hypericum perforatum L.

Journal: Die Pharmazie 20020301

Title: Molecular aspects of photodynamic therapy: low energy pre-sensitization of hypericin-loaded human endometrial carcinoma cells enhances photo-tolerance, alters gene expression and affects the cell cycle.

Journal: FEBS letters 20020213

Title: Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).

Journal: Journal of clinical psychopharmacology 20020201

Title: New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology.

Journal: Urology 20020201

Title: Phototoxic and apoptosis-inducing capacity of pseudohypericin.

Journal: Planta medica 20020201

Title: Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.

Journal: Life sciences 20020201

Title: Hypericin--a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules.

Journal: Current drug targets 20020201

Title: Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.

Journal: International journal of cancer 20020110

Title: Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes.

Journal: International journal of oncology 20020101

Title: A pharmacophore for human pregnane X receptor ligands.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020101

Title: St. John's wort (Hypericum perforatum)--is it safe during breastfeeding?

Journal: Pharmacopsychiatry 20020101

Title: Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20020101

Title: Influence of structure of human, rat, and bovine serum albumins on binding properties of photoactive drug hypericin.

Journal: Biopolymers 20020101

Title: Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort).

Journal: Phytochemical analysis : PCA 20020101

Title: Enhancing the antitumoral effect of hypericin-mediated photodynamic therapy by hyperthermia.

Journal: Lasers in surgery and medicine 20020101

Title: Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

Title: Determination of St. John's wort components in dietary supplements and functional foods by liquid chromatography.

Journal: Journal of AOAC International 20020101

Title: Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.

Journal: Physiological research 20020101

Title: Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells.

Journal: Neuromolecular medicine 20020101

Title: Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011205

Title: High performance liquid chromatographic analysis of St. John's wort with photodiode array detection.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011205

Title: Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations.

Journal: Journal of pharmaceutical and biomedical analysis 20011201

Title: Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.

Journal: British journal of pharmacology 20011201

Title: Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells.

Journal: Journal of photochemistry and photobiology. B, Biology 20011201

Title: Photodynamic therapy in superficial bladder cancer: past, present and future.

Journal: Urological research 20011201

Title: [Induction of callus of Hypericum perforatum L. and qualitative identification of active constituents of its callus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011201

Title: Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells.

Journal: International journal of molecular medicine 20011101

Title: A study of hypericin-induced teratogenicity during organogenesis using a whole rat embryo culture model.

Journal: Fertility and sterility 20011101

Title: [Experimental cultivation of Hypericum perforatum L. in Bratislava].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101

Title: Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).

Journal: Biochemical pharmacology 20011015

Title: [Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)].

Journal: Nederlands tijdschrift voor geneeskunde 20011006

Title: Investigation of some Hypericum species native to Southern of Brazil for antiviral activity.

Journal: Journal of ethnopharmacology 20011001

Title: St. John's Wort: clinical status in psychiatry.

Journal: CNS spectrums 20011001

Title: St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats.

Journal: Molecular psychiatry 20010901

Title: A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.

Journal: International clinical psychopharmacology 20010901

Title: Photodynamic therapy of murine fibrosarcoma with topical and systemic administration of hypericin.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010901

Title: Severe phototoxic reaction to laser treatment in a patient taking St John's Wort.

Journal: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20010901

Title: Effect of hypericin on confocal imaging of Ca2+ signaling in cultured human retinal pigment epithelium.

Journal: Yan ke xue bao = Eye science 20010901

Title: Anti-cancer activities of hypericin in the dark.

Journal: Photochemistry and photobiology 20010801

Title: Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells.

Journal: Photochemistry and photobiology 20010801

Title: Different pathways mediate cytochrome c release after photodynamic therapy with hypericin.

Journal: Photochemistry and photobiology 20010801

Title: Hypericin derivatives: substituent effects on radical-anion formation.

Journal: Photochemistry and photobiology 20010801

Title: Identification of a vibrational frequency corresponding to H-atom translocation in hypericin.

Journal: Photochemistry and photobiology 20010801

Title: In vitro study of the photocytotoxicity of some hypericin analogs on different cell lines.

Journal: Photochemistry and photobiology 20010801

Title: Interaction of hypericin with serum albumins: surface-enhanced Raman spectroscopy, resonance Raman spectroscopy and molecular modeling study.

Journal: Photochemistry and photobiology 20010801

Title: Spectroscopic study of visible-light effects on hypericin-lens proteins systems.

Journal: Photochemistry and photobiology 20010801

Title: The structure of hypericin in solution. Searching for hypericin's 1,6 tautomer.

Journal: Photochemistry and photobiology 20010801

Title: Toward hypericin-derived potential photodynamic therapy agents.

Journal: Photochemistry and photobiology 20010801

Title: Tumor cell toxicity of hypericin and related analogs.

Journal: Photochemistry and photobiology 20010801

Title: Tumor-specific and photodependent cytotoxicity of hypericin in the human LNCaP prostate tumor model.

Journal: Photochemistry and photobiology 20010801

Title: Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.

Journal: International journal of cancer 20010715

Title: Photo-activation of hypericin with low doses of light promotes apparent photo-resistance in human histiocytic lymphoma U937 cells.

Journal: Journal of photochemistry and photobiology. B, Biology 20010701

Title: Role of flavonoids in controlling the phototoxicity of Hypericum perforatum extracts.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010701

Title: Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes.

Journal: Pharmacopsychiatry 20010701

Title: Neurochemical studies with St. John's wort in vitro.

Journal: Pharmacopsychiatry 20010701

Title: Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.

Journal: Pharmacopsychiatry 20010701

Title: Batch-to-batch reproducibility of St. John's wort preparations.

Journal: Pharmacopsychiatry 20010701

Title: Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment.

Journal: Pharmacopsychiatry 20010701

Title: Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.

Journal: Pharmacopsychiatry 20010701

Title: In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.

Journal: Pharmacopsychiatry 20010701

Title: St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells.

Journal: Pharmacopsychiatry 20010701

Title: Interleukin-6 involvement in antidepressant action of Hypericum perforatum.

Journal: Pharmacopsychiatry 20010701

Title: Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices.

Journal: Pharmacopsychiatry 20010701

Title: Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts.

Journal: Drug development and industrial pharmacy 20010701

Title: Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells.

Journal: International journal of oncology 20010601

Title: Effect of St. John's wort on free radical production.

Journal: Life sciences 20010601

Title: Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by hpyericin, an active component of Hypericum perforatum.

Journal: Planta medica 20010601

Title: In vivo photodynamic activity of hypericin in transitional cell carcinoma bladder tumors.

Journal: International journal of oncology 20010501

Title: St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.

Journal: The Journal of pharmacy and pharmacology 20010501

Title: Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos.

Journal: Theriogenology 20010501

Title: Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy.

Journal: International journal of oncology 20010401

Title: Single-dose and steady-state administration of Hypericum perforatum extract (St John's Wort) does not influence skin sensitivity to UV radiation, visible light, and solar-simulated radiation.

Journal: Archives of dermatology 20010401

Title: Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent.

Journal: Photochemistry and photobiology 20010401

Title: Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).

Journal: Planta medica 20010401

Title: Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8.

Journal: FEBS letters 20010323

Title: Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort).

Journal: Phytochemistry 20010301

Title: Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology.

Journal: Journal of psychopharmacology (Oxford, England) 20010301

Title: Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum.

Journal: Pharmacopsychiatry 20010301

Title: Incidence and clinical relevance of the interactions and side effects of Hypericum preparations.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010301

Title: Is the excited-state H-atom transfer in hypericin concerted?

Journal: Photochemistry and photobiology 20010201

Title: Solvatochromic effects in the electronic absorption and nuclear magnetic resonance spectra of hypericin in organic solvents and in lipid bilayers.

Journal: Photochemistry and photobiology 20010201

Title: Photochemical effects and hypericin photosensitized processes in collagen.

Journal: Journal of biomedical optics 20010101

Title: Absorbance data of hypericin and pseudohypericin used as reference compounds for medicinal plant analysis.

Journal: Die Pharmazie 20010101

Title: Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates.

Journal: Cancer chemotherapy and pharmacology 20010101

Title: Light-induced photoactivation of hypericin inhibits cellular growth in pituitary adenoma cell line AtT20/D16v-F2 (hypericin inhibits cellular growth of AtT20/D16v-F2).

Journal: Acta medica (Hradec Kralove) 20010101

Title: Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20010101

Title: Comparative evaluation of St. John's wort from different Italian regions.

Journal: Farmaco (Societa chimica italiana : 1989) 20010101

Title: Comparison of German St. John's wort products according to hyperforin and total hypericin content.

Journal: Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) 20010101

Title: Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil.

Journal: International journal of toxicology 20010101

Title: Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines.

Journal: Lasers in medical science 20010101

Title: Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin.

Journal: Anticancer research 20010101

Title: [Hyperici herba (Hypericum perforatum L].

Journal: Acta pharmaceutica Hungarica 20010101

Title: Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring.

Journal: Neurotoxicology and teratology 20010101

Title: Improved procedure for the quality control of Hypericum perforatum L.

Journal: Phytochemical analysis : PCA 20010101

Title: The effect of quercetin on light-induced cytotoxicity of hypericin.

Journal: Physiological research 20010101

Title: St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20000620

Title: [Studies on synthesis and anti-HIV RT activity of hypericin and ethylhypericin].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 19980101

Title: Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.

Journal: Research in virology 19970101

Title: Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930101

Title: Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.

Journal: Antiviral research 19920101

Title: In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives.

Journal: Antiviral research 19910901

Title: Antiviral activities of hypericin.

Journal: Antiviral research 19910201

Title: Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.

Journal: Antiviral research 19900601

Title: Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19890801

Title: Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19880701

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Tags:548-04-9 Molecular Formula|548-04-9 MDL|548-04-9 SMILES|548-04-9 Hypericin