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60133-18-8,MFCD00869499
Catalog No.:AA00IAKN

60133-18-8 | 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol,(1a,3b,5Z,7E,22E)-

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1mg
≥98%
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$245.00   $171.00
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5mg
≥98%
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$953.00   $667.00
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10mg
97%
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$1,732.00   $1,213.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IAKN
Chemical Name:
9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol,(1a,3b,5Z,7E,22E)-
CAS Number:
60133-18-8
Molecular Formula:
C28H44O3
Molecular Weight:
428.6472
MDL Number:
MFCD00869499
SMILES:
O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](/C=C/[C@@H](C(O)(C)C)C)C)C)/C1
Properties
Computed Properties
 
Complexity:
758  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
4.9  

Literature

Title: Studies on the mechanisms of superagonistic pro-differentiating activities of side-chain modified analogs of vitamin D2.

Journal: Oncology reports 20120901

Title: Evaluation of bone markers in hypophosphatemic rickets/osteomalacia.

Journal: Endocrine 20111001

Title: Quantification of 1α,25-dihydroxy vitamin D by immunoextraction and liquid chromatography-tandem mass spectrometry.

Journal: Clinical chemistry 20110901

Title: Determination of 1,25-dihydroxyvitamin D2 in rat serum using liquid chromatography with tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115

Title: Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis.

Journal: Atherosclerosis 20091201

Title: The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone.

Journal: American journal of physiology. Renal physiology 20090901

Title: Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model.

Journal: Cancer chemotherapy and pharmacology 20081001

Title: Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D.

Journal: Current opinion in nephrology and hypertension 20070701

Title: The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.

Journal: Oncology research 20070101

Title: Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2.

Journal: Biochimica et biophysica acta 20060201

Title: Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice.

Journal: Molecular endocrinology (Baltimore, Md.) 20040901

Title: Rat cytochrome P450C24 (CYP24) does not metabolize 1,25-dihydroxyvitamin D2 to calcitroic acid.

Journal: Journal of cellular biochemistry 20030201

Title: Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners.

Journal: Steroids 20020801

Title: Toxicity and dose-response studies of 1alpha-hydroxyvitamin D2 in a retinoblastoma xenograft model.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20020501

Title: Calcitroic acid is a major catabolic metabolite in the metabolism of 1 alpha-dihydroxyvitamin D(2).

Journal: Archives of biochemistry and biophysics 20010801

Title: Relative potencies of 1,25-(OH)(2)D(3) and 19-Nor-1,25-(OH)(2)D(2) on inducing differentiation and markers of bone formation in MG-63 cells.

Journal: Journal of the American Society of Nephrology : JASN 20010701

Title: Metabolic and endocrine effects of metabolic acidosis in humans.

Journal: Swiss medical weekly 20010310

Title: Progressively increased serum 1,25-dihydroxyvitamin D2 concentration in a hypoparathyroid patient with protracted hypercalcemia due to vitamin D2 intoxication.

Journal: Endocrine journal 19940801

Title: Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209.

Title: Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135.

Title: Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199

Title: Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

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Tags:60133-18-8 Molecular Formula|60133-18-8 MDL|60133-18-8 SMILES|60133-18-8 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol,(1a,3b,5Z,7E,22E)-