76-83-5
5508-58-7
[1]Cava;Weinstein[Chemistryandindustry,1959,p.851]Cavaetal.[Tetrahedron,1962,vol.18,p.397,398][Tetrahedron,1965,vol.21,p.2617,2620Anm.11]
[1]Schwyzeretal.[HelveticaChimicaActa,1951,vol.34,p.652,670]Gorter[RecueildesTravauxChimiquesdesPays-Bas,1911,vol.30,p.165][ChemischesZentralblatt,1910,vol.81,#II,p.1229]
[2]Kondoetal.[ItsuuKenkyushoNempo,1950,vol.1,p.25,27,65,68]
[1]Schwyzeretal.[HelveticaChimicaActa,1951,vol.34,p.652,670]Chakravarti;Chakravarti[JournaloftheChemicalSociety,1952,p.1697,1699]
[1]Schwyzeretal.[HelveticaChimicaActa,1951,vol.34,p.652,670]Moktader;Guha-Sircar[JournaloftheIndianChemicalSociety,1939,vol.16,p.333,338]
[1]Kondoetal.[ItsuuKenkyushoNempo,1950,vol.1,p.25,27,65,68]
Title: Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells.
Journal: Environmental toxicology 20180301
Title: Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway.
Journal: Toxicology 20180301
Title: Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action.
Journal: Biochemical pharmacology 20170901
Title: Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA.
Journal: Chemico-biological interactions 20170801
Title: Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.
Journal: Environmental toxicology 20170301
Title: Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation.
Journal: Oncotarget 20161206
Title: Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBPβ expression and activation.
Journal: Toxicology and applied pharmacology 20160915
Title: Enhanced protective activity of nano formulated andrographolide against arsenic induced liver damage.
Journal: Chemico-biological interactions 20151205
Title: Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
Journal: Journal of natural products 20150227
Title: Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats.
Journal: Toxicology and applied pharmacology 20141001
Title: Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade.
Journal: Chemico-biological interactions 20140725
Title: Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
Journal: Bioorganic & medicinal chemistry letters 20140515
Title: Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin via enhancing apoptosis pathways in vitro and in vivo.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140501
Title: Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.
Journal: Toxicology letters 20130912
Title: S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.
Journal: Free radical biology & medicine 20130801
Title: Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide.
Journal: International journal of biological macromolecules 20121201
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.
Journal: Journal of pharmaceutical and biomedical analysis 20121101
Title: Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.
Journal: Carcinogenesis 20121101
Title: Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells.
Journal: Journal of medicinal chemistry 20121025
Title: Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.
Journal: Biochemical pharmacology 20121001
Title: Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.
Journal: European journal of medicinal chemistry 20121001
Title: Two novel creatinine adducts of andrographolide in human urine.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120901
Title: Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway.
Journal: Current molecular medicine 20120901
Title: Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents.
Journal: Archiv der Pharmazie 20120801
Title: Inhibitory effect of andrographolide in 3T3-L1 adipocytes differentiation through the PPARγ pathway.
Journal: Molecular and cellular endocrinology 20120706
Title: Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells.
Journal: Life sciences 20120627
Title: Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells.
Journal: Journal of ethnopharmacology 20120601
Title: Effects of andrographolide on the activation of mitogen activated protein kinases and nuclear factor-κB in mouse peritoneal macrophage-derived foam cells.
Journal: Chinese journal of integrative medicine 20120501
Title: Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran's pharmaceutical plants.
Journal: Molecular biology reports 20120501
Title: The genotoxicity and cytotoxicity assessments of andrographolide in vitro.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: Therapeutic potential of andrographolide for treating endometriosis.
Journal: Human reproduction (Oxford, England) 20120501
Title: Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells.
Journal: Canadian journal of physiology and pharmacology 20120501
Title: [Effects of andrographolide on the expression of eosinophil granulocytes and possible mechanisms].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120501
Title: Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.
Journal: Clinical and experimental pharmacology & physiology 20120301
Title: Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells.
Journal: Autophagy 20120301
Title: Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301
Title: Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215
Title: Effects of andrographolide and 14-deoxy-11,12-didehydroandrographolide on cultured primary astrocytes and PC12 cells.
Journal: Life sciences 20120213
Title: Overlapping elution-extrusion counter-current chromatography: a novel method for efficient purification of natural cytotoxic andrographolides from Andrographis paniculata.
Journal: Journal of chromatography. A 20120203
Title: Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression.
Journal: Immunopharmacology and immunotoxicology 20120201
Title: Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
Journal: Cell biology and toxicology 20120201
Title: Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011).
Journal: Expert opinion on therapeutic patents 20120201
Title: [Study on andrographolide-induced apoptosis of Candida albicans biofilm dispersion cells].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201
Title: Reaction characteristics of andrographolide and its analogue AL-1 with GSH, as a simple chemical simulation of NF-κB inhibition.
Journal: Molecules (Basel, Switzerland) 20120112
Title: Protective effect of andrographolide against concanavalin A-induced liver injury.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120101
Title: Quantification of andrographolide sodium bisulphite in urine after intravenous injection to rats by LC-MS/MS.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120101
Title: New substituted C-19-andrographolide analogues with potent cytotoxic activities.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: [Structure and properties of proprotein convertase inhibitors].
Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101
Title: Rapid detection of apoptosis in mammalian cells by using intact cell MALDI mass spectrometry.
Journal: The Analyst 20111221
Title: A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP.
Journal: Journal of molecular medicine (Berlin, Germany) 20111201
Title: Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201
Title: Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production.
Journal: International immunopharmacology 20111201
Title: Chemometrics evaluation of the herbal drug Andrographis paniculata.
Journal: Natural product communications 20111201
Title: Inhibition of TNF-α-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway.
Journal: Journal of natural products 20111128
Title: Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.
Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20111101
Title: Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein.
Journal: Journal of pharmaceutical sciences 20111101
Title: The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20111001
Title: Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain injury.
Journal: Planta medica 20111001
Title: Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation.
Journal: Journal of dental research 20111001
Title: Effect of andrographolide on cysteamine-induced duodenal ulcer in rats.
Journal: Natural product research 20110901
Title: Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells.
Journal: Molecular carcinogenesis 20110801
Title: [Intestinal absorption of enteric coating potassium sodium dehydroandroan drographolide succinate pellets in rat and in vivo pharmacokinetics study].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110801
Title: Identification of potassium dehydroandrographolidi succinas and its major metabolites in rat urine by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715
Title: Andrographolide inhibits intimal hyperplasia in a rat model of autogenous vein grafts.
Journal: Cell biochemistry and biophysics 20110701
Title: In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities.
Journal: Journal of natural medicines 20110701
Title: Proteomic alterations in mouse kidney induced by andrographolide sodium bisulfite.
Journal: Acta pharmacologica Sinica 20110701
Title: [Effects of andrographolide on the concentration of cytokines in BALF and the expressions of type I and III collagen mRNA in lung tissue in bleomycin-induced rat pulmonary fibrosis].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110701
Title: Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
Journal: Journal of natural products 20110624
Title: Stage of action of naturally occurring andrographolides and their semisynthetic analogues against herpes simplex virus type 1 in vitro.
Journal: Planta medica 20110601
Title: The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.
Journal: Leukemia & lymphoma 20110601
Title: Development of andrographolide molecularly imprinted polymer for solid-phase extraction.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110601
Title: Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway.
Journal: Journal of ethnopharmacology 20110601
Title: [Andrographolide inhibits extracellular signal-regulated kinase 1/2 signaling pathway in activated macrophages].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110601
Title: Andrographolide inhibits ICAM-1 expression and NF-κB activation in TNF-α-treated EA.hy926 cells.
Journal: Journal of agricultural and food chemistry 20110525
Title: A potential andrographolide analogue against the replication of herpes simplex virus type 1 in vero cells.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20110501
Title: Andrographolide and 14-deoxy-11, 12-didehydroandrographolide inhibit cytochrome P450s in HepG2 hepatoma cells.
Journal: Life sciences 20110227
Title: Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20110225
Title: Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes.
Journal: Toxicology 20110204
Title: Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells.
Journal: Toxicology and applied pharmacology 20110201
Title: Prediction of the relationship between the structural features of andrographolide derivatives and α-glucosidase inhibitory activity: a quantitative structure-activity relationship (QSAR) study.
Journal: Journal of enzyme inhibition and medicinal chemistry 20110201
Title: Andrographolide attenuates tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes.
Journal: Molecular and cellular endocrinology 20110130
Title: Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with d-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis.
Journal: Toxicology and applied pharmacology 20110101
Title: Andrographolide-induced pi class of glutathione S-transferase gene expression via PI3K/Akt pathway in rat primary hepatocytes.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110101
Title: Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles.
Journal: European journal of drug metabolism and pharmacokinetics 20110101
Title: Effect of the derivatives of andrographolide on the morphology of Bacillus subtilis.
Journal: Archives of pharmacal research 20110101
Title: Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis.
Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20110101
Title: Protective mechanism of andrographolide against carbon tetrachloride-induced acute liver injury in mice.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent.
Journal: Bioorganic & medicinal chemistry letters 20101201
Title: Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines.
Journal: Journal of ethnopharmacology 20101111
Title: Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity.
Journal: Planta medica 20101101
Title: Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression.
Journal: International immunopharmacology 20101101
Title: Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer.
Journal: Planta medica 20101001
Title: Mitochondrial-mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20101001
Title: A novel microwave-assisted extraction for the isolation of andrographolide from Andrographis paniculata and its in vitro antioxidant activity.
Journal: Natural product research 20101001
Title: Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia.
Journal: British journal of pharmacology 20101001
Title: Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis.
Journal: Apoptosis : an international journal on programmed cell death 20100801
Title: Biosynthesis of andrographolide in Andrographis paniculata.
Journal: Phytochemistry 20100801
Title: [Assay of andrographolide bulk drug by HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801
Title: Andrographolide sensitizes Ras-transformed cells to radiation in vitro and in vivo.
Journal: International journal of radiation oncology, biology, physics 20100715
Title: Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells.
Journal: Journal of agricultural and food chemistry 20100714
Title: Effects of andrographolide on sexual functions, vascular reactivity and serum testosterone level in rodents.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100701
Title: Synthesis and preliminary anti-HIV activities of andrographolide derivatives.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20100701
Title: Design, synthesis and antibacterial activity of novel andrographolide derivatives.
Journal: Bioorganic & medicinal chemistry 20100615
Title: Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin.
Journal: Biochemical pharmacology 20100501
Title: Anticancer activity of andrographolide semisynthetic derivatives.
Journal: Natural product communications 20100501
Title: [A quantitation method for andrographolide and dehydroandrographolide by X-ray powder diffraction Fourier fingerprint pattern technique].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100501
Title: Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway.
Journal: European journal of pharmacology 20100425
Title: Andrographolide regulates epidermal growth factor receptor and transferrin receptor trafficking in epidermoid carcinoma (A-431) cells.
Journal: British journal of pharmacology 20100401
Title: [Research on determination of chemical purity of andrographolide by coulometric titration method].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401
Title: Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats.
Journal: Chemico-biological interactions 20100330
Title: Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100318
Title: Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.
Journal: Journal of agricultural and food chemistry 20100224
Title: Activation of the cAMP/CREB/inducible cAMP early repressor pathway suppresses andrographolide-induced gene expression of the pi class of glutathione S-transferase in rat primary hepatocytes.
Journal: Journal of agricultural and food chemistry 20100210
Title: Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response.
Journal: Acta pharmacologica Sinica 20100201
Title: Hydrophobic solvent induced phase transition extraction to extract drugs from plasma for high performance liquid chromatography-mass spectrometric analysis.
Journal: Journal of chromatography. A 20100115
Title: Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome.
Journal: Journal of the science of food and agriculture 20100115
Title: Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models.
Journal: Biological research for nursing 20100101
Title: QSAR Studies on andrographolide derivatives as α-glucosidase inhibitors.
Journal: International journal of molecular sciences 20100101
Title: Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations.
Journal: International journal of nanomedicine 20100101
Title: Synergistic increases of metabolism and oxidation-reduction genes on their expression after combined treatment with a CYP1A inducer and andrographolide.
Journal: Chemico-biological interactions 20091210
Title: The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Journal: Journal of agricultural and food chemistry 20091111
Title: Evaluation of molecular pharmaceutical and in-vivo properties of spray-dried isolated andrographolide-PVP.
Journal: The Journal of pharmacy and pharmacology 20091101
Title: Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus.
Journal: Immunology 20090901
Title: Absorption of andrographolides from Andrographis paniculata and its effect on CCl(4)-induced oxidative stress in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901
Title: Analgesic, antipyretic, anti-inflammatory and toxic effects of andrographolide derivatives in experimental animals.
Journal: Archives of pharmacal research 20090901
Title: Andrographolide inhibits hepatoma cells growth and affects the expression of cell cycle related proteins.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090901
Title: Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression.
Journal: Chemico-biological interactions 20090814
Title: Activity of andrographolide and its derivatives against influenza virus in vivo and in vitro.
Journal: Biological & pharmaceutical bulletin 20090801
Title: Physicochemical characteristics and oral bioavailability of andrographolide complexed with hydroxypropyl-beta-cyclodextrin.
Journal: Die Pharmazie 20090801
Title: Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide.
Journal: Phytotherapy research : PTR 20090701
Title: Synthesis and evaluation of antibacterial activities of andrographolide analogues.
Journal: European journal of medicinal chemistry 20090701
Title: Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata.
Journal: Planta medica 20090601
Title: Potency of andrographolide as an antitumor compound in BHC-induced liver damage.
Journal: Integrative cancer therapies 20090601
Title: Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures.
Journal: Chemico-biological interactions 20090515
Title: Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells.
Journal: Cancer letters 20090418
Title: A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway.
Journal: American journal of respiratory and critical care medicine 20090415
Title: Oxidative stress in the brain of nicotine-induced toxicity: protective role of Andrographis paniculata Nees and vitamin E.
Journal: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20090401
Title: Computational study on the molecular inclusion of andrographolide by cyclodextrin.
Journal: Journal of computer-aided molecular design 20090301
Title: In vitro and in vivo anti-inflammatory effects of andrographolide.
Journal: International immunopharmacology 20090301
Title: A simple and sensitive HPLC-ESI-MS/MS method for the determination of andrographolide in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215
Title: NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis.
Journal: The Journal of biological chemistry 20090213
Title: In vitro nicotine induced superoxide mediated DNA fragmentation in lymphocytes: protective role of Andrographis paniculata Nees.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201
Title: Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation.
Journal: European journal of pharmacology 20090114
Title: Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis.
Journal: The Journal of pharmacy and pharmacology 20090101
Title: Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Journal: Journal of translational medicine 20090101
Title: Intracellular glutathione regulates Andrographolide-induced cytotoxicity on hepatoma Hep3B cells.
Journal: Redox report : communications in free radical research 20090101
Title: Analysis of urinary andrographolides and antioxidant status after oral administration of Andrographis paniculata leaf extract in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201
Title: [Andrographolide drop-pill in treatment of acute upper respiratory tract infection with external wind-heat syndrome: a multicenter and randomized controlled trial].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20081201
Title: Identification of four urea adducts of andrographolide in humans.
Journal: Drug metabolism letters 20081201
Title: Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis.
Journal: British journal of pharmacology 20081101
Title: Inhibition of the epstein-barr virus lytic cycle by andrographolide.
Journal: Biological & pharmaceutical bulletin 20081101
Title: Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Journal: Journal of pharmacological sciences 20081001
Title: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
Journal: Medicinal research reviews 20080901
Title: Molecular interaction between andrographolide and glutathione follows second order kinetics.
Journal: Chemical & pharmaceutical bulletin 20080901
Title: Simultaneous determination of four andrographolides in Andrographis paniculata Nees by silver ion reversed-phase high-performance liquid chromatography.
Journal: Journal of chromatographic science 20080901
Title: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide.
Journal: Chemico-biological interactions 20080811
Title: Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation.
Journal: Molecular cancer therapeutics 20080701
Title: Mediation of beta-endorphin in andrographolide-induced plasma glucose-lowering action in type I diabetes-like animals.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080601
Title: ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.
Journal: Journal of natural products 20080501
Title: Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia/reoxygenation injury.
Journal: The Journal of pharmacology and experimental therapeutics 20080401
Title: Modulation of the expression of the pi class of glutathione S-transferase by Andrographis paniculata extracts and andrographolide.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301
Title: Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Journal: The Journal of biological chemistry 20080222
Title: Quality control of medicinal herbs Fructus gardeniae, Common Andrographis Herb and their preparations for their active constituents by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry.
Journal: Talanta 20080215
Title: Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide.
Journal: Journal of ethnopharmacology 20080212
Title: Effect and mechanism of andrographolide on the recovery of Pseudomonas aeruginosa susceptibility to several antibiotics.
Journal: The Journal of international medical research 20080101
Title: Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level.
Journal: Journal of Asian natural products research 20080101
Title: In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide.
Journal: Acta biochimica Polonica 20080101
Title: Synthesis of andrographolide derivatives and their TNF-alpha and IL-6 expression inhibitory activities.
Journal: Bioorganic & medicinal chemistry letters 20071215
Title: Determination of andrographolide and dehydroandrographolide in rabbit plasma by on-line solid phase extraction of high-performance liquid chromatography.
Journal: Talanta 20071115
Title: Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal hyperplasia in arterial restenosis.
Journal: Cell research 20071101
Title: Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes.
Journal: Toxicology and applied pharmacology 20071015
Title: Andrographolide inhibits human hepatoma-derived Hep3B cell growth through the activation of c-Jun N-terminal kinase.
Journal: Planta medica 20071001
Title: [Advances in study on anti-tumor mechanism of andrographolide].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001
Title: Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury.
Journal: Integrative cancer therapies 20070901
Title: Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species.
Journal: European journal of pharmacology 20070730
Title: HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorporated in liposomes and tablets.
Journal: Biomedical chromatography : BMC 20070701
Title: Determination of andrographolide in human plasma by high-performance liquid chromatography/mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701
Title: Synthesis of andrographolide derivatives: a new family of alpha-glucosidase inhibitors.
Journal: Bioorganic & medicinal chemistry 20070615
Title: Membrane transport of andrographolide in artificial membrane and rat small intestine.
Journal: Pakistan journal of biological sciences : PJBS 20070615
Title: Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice.
Journal: Journal of ethnopharmacology 20070420
Title: Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide.
Journal: International immunopharmacology 20070401
Title: Semisynthesis and in vitro anticancer activities of andrographolide analogues.
Journal: Phytochemistry 20070301
Title: Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice.
Journal: Integrative cancer therapies 20070301
Title: Antiangiogenic activity of Andrographis paniculata extract and andrographolide.
Journal: International immunopharmacology 20070201
Title: On-line coupling of dynamic microwave-assisted extraction with high-performance liquid chromatography for determination of andrographolide and dehydroandrographolide in Andrographis paniculata Nees.
Journal: Journal of chromatography. A 20070126
Title: Entrapment of andrographolide in cross-linked alginate pellets: I. Formulation and evaluation of associated release kinetics.
Journal: Pakistan journal of pharmaceutical sciences 20070101
Title: Entrapment of andrographolide in cross-linked alginate pellets: II. Physicochemical characterization to study the pelletization of andrographolide.
Journal: Pakistan journal of pharmaceutical sciences 20070101
Title: Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide.
Journal: Immunopharmacology and immunotoxicology 20070101
Title: Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.
Journal: Anticancer research 20070101
Title: Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation.
Journal: European journal of pharmacology 20061228
Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
Journal: Journal of molecular graphics & modelling 20061101
Title: Bisandrographolide from Andrographis paniculata activates TRPV4 channels.
Journal: The Journal of biological chemistry 20061006
Title: Oxidation studies on Andrographolide.
Journal: Natural product research 20061001
Title: [Studies on diterpenoids from Andrographis paniculata].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001
Title: Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity.
Journal: Integrative cancer therapies 20060901
Title: Stability of andrographolide in powdered Andrographis herb under accelerated conditions.
Journal: Planta medica 20060801
Title: Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.
Journal: Biochemical pharmacology 20060714
Title: [Effect of andrographolide on QS regulating virulence factors production in Pseudomonas aeruginosa].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060601
Title: Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.
Journal: Bioorganic & medicinal chemistry letters 20060515
Title: [Fast determination of andrographolide and dehydroandrographolide in Xiaoyanlidan Tablets by microemulsion electrokinetic chromatography].
Journal: Se pu = Chinese journal of chromatography 20060501
Title: Semisynthesis and cytotoxic activities of andrographolide analogues.
Journal: Journal of enzyme inhibition and medicinal chemistry 20060401
Title: ent-Labdane diterpenoids from Andrographis paniculata.
Journal: Journal of natural products 20060301
Title: Andropanolide and isoandrographolide, minor diterpenoids from Andrographis paniculata: structure and X-ray crystallographic analysis.
Journal: Journal of natural products 20060301
Title: Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: role of mitogen-activated protein kinases.
Journal: Biological & pharmaceutical bulletin 20060201
Title: Simultaneous determination of andrographolide and dehydroandrographolide in Andrographis paniculata and Chinese medicinal preparations by microemulsion electrokinetic chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20060123
Title: Natural products in combinatorial chemistry: an andrographolide-based library.
Journal: Journal of combinatorial chemistry 20060101
Title: Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1.
Journal: Phytotherapy research : PTR 20051201
Title: Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells.
Journal: Planta medica 20051201
Title: Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis.
Journal: Journal of cellular biochemistry 20050801
Title: Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis.
Journal: Planta medica 20050501
Title: Isolation and identification of seven glucuronide conjugates of andrographolide in human urine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050401
Title: A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity.
Journal: Natural product research 20050401
Title: Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells.
Journal: British journal of pharmacology 20050301
Title: Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse.
Journal: The Journal of pharmacology and experimental therapeutics 20050101
Title: Morphological and biochemical changes of andrographolide-induced cell death in human prostatic adenocarcinoma PC-3 cells.
Journal: In vivo (Athens, Greece) 20050101
Title: Activation of alpha1A-adrenoceptor by andrographolide to increase glucose uptake in cultured myoblast C2C12 cells.
Journal: Planta medica 20041201
Title: [Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20041101
Title: Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
Journal: Bioorganic & medicinal chemistry letters 20040920
Title: Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040915
Title: Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
Journal: European journal of pharmacology 20040913
Title: Four new andrographolide metabolites in human urine.
Journal: Chemical & pharmaceutical bulletin 20040601
Title: Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway.
Journal: Biochemical pharmacology 20040401
Title: Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation.
Journal: The Journal of pharmacology and experimental therapeutics 20040301
Title: DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells.
Journal: BMC cancer 20040101
Title: Chemical fingerprinting of Andrographis paniculata using HPLC, HPTLC and densitometry.
Journal: Phytochemical analysis : PCA 20040101
Title: Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees.
Journal: Phytochemical analysis : PCA 20040101
Title: Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats.
Journal: Planta medica 20031201
Title: Identification of a rare sulfonic acid metabolite of andrographolide in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030801
Title: Six new andrographolide metabolites in rats.
Journal: Chemical & pharmaceutical bulletin 20030501
Title: [Advances in pharmacological study of andrographolide and its derivatives].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030201
Title: Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography.
Journal: Journal of chromatography. A 20030110
Title: Heat-accelerated degradation of solid-state andrographolide.
Journal: Chemical & pharmaceutical bulletin 20030101
Title: In vitro antileishmanial effects of antibacterial diterpenes from two Ethiopian Premna species: P. schimperi and P. oligotricha.
Journal: BMC pharmacology 20030101
Title: Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.
Journal: Journal of experimental therapeutics & oncology 20030101
Title: [Changes of dehydroandrographolide's contents of andrographis tablet in the process of production].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20021201
Title: A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20021001
Title: Effect of andrographolide and Kan Jang--fixed combination of extract SHA-10 and extract SHE-3--on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20021001
Title: [Determination of andrographolide and dehydroandrographolide in Andrographis paniculata nees materials and related patent medicines by reversed-phase high performance liquid chromatography].
Journal: Se pu = Chinese journal of chromatography 20020901
Title: Crystal structure of 8-chloroandrographolide triacetate.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020401
Title: [Study on extraction of active ingredients from Andrographis paniculatal using the orthogonal experiment with supercritical carbon dioxide].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020201
Title: [Modulation of lianbizi injection (andrographolide) on some immune functions].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020201
Title: Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect.
Journal: British journal of pharmacology 20020101
Title: Determination of andrographolide, deoxyandrographolide and neoandrographolide in the Chinese herb Andrographis paniculata by micellar electrokinetic capillary chromatography.
Journal: Phytochemical analysis : PCA 20020101
Title: Steroid hormone activity of flavonoids and related compounds.
Journal: Breast cancer research and treatment 20000701
Title: Dehydroandrographolide succinic acid monoester as an inhibitor against the human immunodeficiency virus.
Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19910501
Title: Purification and properties of potato 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-(1,4-alpha-glucano)-transferase. Evidence against a dual catalytic function in amylose-branching enzyme.
Journal: European journal of biochemistry 19751115
Title: Zhai ZJ, et al. Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 2014 Feb;171(3):663-75.
Title: Gupta S, et al. Broad-spectrum antiviral properties of andrographolide. Arch Virol. 2017 Mar;162(3):611-623.
