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552-94-3,MFCD00020252
Catalog No.:AA003U45

552-94-3 | Salsalate

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5g
98%(HPLC)
in stock  
$24.00   $17.00
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25g
>98.0%(T)(HPLC)
in stock  
$34.00   $24.00
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500g
95%
in stock  
$477.00   $334.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003U45
Chemical Name:
Salsalate
CAS Number:
552-94-3
Molecular Formula:
C14H10O5
Molecular Weight:
258.2262
MDL Number:
MFCD00020252
SMILES:
Oc1ccccc1C(=O)Oc1ccccc1C(=O)O
Properties
Properties
 
BP:
482.9°C at 760 mmHg  
Form:
Solid  
MP:
148-151°C  
Refractive Index:
1.4825 (estimate)  
Solubility:
DMSO: ≥15mg/mL  
Stability:
Moisture Sensitive  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
341  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3  

Literature

Title: Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats.

Journal: Biopharmaceutics & drug disposition 20120901

Title: The ancient drug salicylate directly activates AMP-activated protein kinase.

Journal: Science (New York, N.Y.) 20120518

Title: Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.

Journal: Diabetes 20120401

Title: [Benefits and risks of current pharmacotherapy in the treatment of type 2 diabetes].

Journal: Der Internist 20120401

Title: Regulation of muscle microcirculation in health and diabetes.

Journal: Diabetes & metabolism journal 20120401

Title: Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression.

Journal: Medical hypotheses 20120201

Title: Inflammatory cause of metabolic syndrome via brain stress and NF-κB.

Journal: Aging 20120201

Title: Regenerative therapies for diabetic microangiopathy.

Journal: Experimental diabetes research 20120101

Title: Juvenile myoclonic epilepsy presenting as a new daily persistent-like headache.

Journal: The journal of headache and pain 20111201

Title: Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.

Journal: The Journal of pharmacology and experimental therapeutics 20111201

Title: Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease.

Journal: Medical hypotheses 20111001

Title: A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors.

Journal: Chemical biology & drug design 20111001

Title: Current and future drug targets in weight management.

Journal: Pharmaceutical research 20110801

Title: Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans.

Journal: Diabetes care 20110701

Title: Central hypothyroidism.

Journal: Indian journal of endocrinology and metabolism 20110701

Title: Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions.

Journal: The Journal of clinical endocrinology and metabolism 20110501

Title: Prescription pattern of NSAIDs and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients in clinical practice in Korea.

Journal: Journal of Korean medical science 20110401

Title: 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults.

Journal: Hypertension (Dallas, Tex. : 1979) 20110101

Title: Pharmacological and non-pharmacological interventions to influence adipose tissue function.

Journal: Cardiovascular diabetology 20110101

Title: Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study.

Journal: PloS one 20110101

Title: Inflammatory concepts of obesity.

Journal: International journal of inflammation 20110101

Title: Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats.

Journal: Diabetes 20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Wet oxidation of salicylic acid solutions.

Journal: Environmental science & technology 20101115

Title: A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease.

Journal: Diabetes 20101101

Title: An overview of salsalate as a potential antidiabetic therapy.

Journal: Drugs of today (Barcelona, Spain : 1998) 20101101

Title: The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part III: Specific Management and Surgical Aspects.

Journal: Current cardiology reviews 20101101

Title: Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome.

Journal: Medical hypotheses 20100901

Title: Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.

Journal: AIDS (London, England) 20100731

Title: 2009 World Congress on the Insulin Resistance Syndrome: cardiovascular disease concepts.

Journal: Diabetes care 20100701

Title: Development of a disposable amperometric biosensor for salicylate based on a plastic electrochemical microcell.

Journal: Biosensors & bioelectronics 20100615

Title: Delayed recrudescence to toxic salicylate concentrations after salsalate overdose.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100601

Title: Health trends.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20100401

Title: Summaries for patients. The effects of salsalate on blood sugar control in people with type 2 diabetes.

Journal: Annals of internal medicine 20100316

Title: The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial.

Journal: Annals of internal medicine 20100316

Title: Beta-lactamase inhibitory component from the roots of Fissistigma cavaleriei.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100201

Title: Potential role of salicylates in type 2 diabetes.

Journal: The Annals of pharmacotherapy 20100101

Title: Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice.

Journal: Mediators of inflammation 20100101

Title: Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury.

Journal: Pharmacoepidemiology and drug safety 20091001

Title: The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation.

Journal: Diabetes 20090901

Title: Role of NFkappaB in age-related vascular endothelial dysfunction in humans.

Journal: Aging 20090801

Title: Serum concentration-dependent hepatotoxicity in individuals receiving oral salsalate.

Journal: Digestive diseases and sciences 20090601

Title: Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.

Journal: Circulation 20090310

Title: The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study.

Journal: Diabetologia 20090301

Title: Inflammation, insulin resistance, and type 2 diabetes: back to the future?

Journal: Diabetes 20090201

Title: A randomized trial of low-dose aspirin in the prevention of clinical type 2 diabetes in women.

Journal: Diabetes care 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.

Journal: Bioorganic & medicinal chemistry 20080915

Title: siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.

Journal: Diabetes 20080801

Title: Approaches to treatment of pre-diabetes and obesity and promising new approaches to type 2 diabetes.

Journal: Diabetes care 20080701

Title: Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes.

Journal: Clinical and translational science 20080501

Title: Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.

Journal: AIDS (London, England) 20080312

Title: Salsalate improves glycemia and inflammatory parameters in obese young adults.

Journal: Diabetes care 20080201

Title: Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy.

Journal: Integrative cancer therapies 20060901

Title: Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk.

Journal: Drug safety 20060101

Title: Salicylic acid-induced inactivation of creatine kinase in the presence of lactoperoxidase and H2O2.

Journal: Chemico-biological interactions 20050115

Title: Phenolic compounds, sodium salicylate and related compounds, as inhibitors of tumor cell growth and inducers of apoptosis in mouse leukemia L1210 cells.

Journal: In vivo (Athens, Greece) 20050101

Title: Aspirin and NSAID sensitivity.

Journal: Immunology and allergy clinics of North America 20040801

Title: Variable effects of nonsteroidal antiinflammatory agents on thyroid test results.

Journal: The Journal of clinical endocrinology and metabolism 20031201

Title: Interaction of rofecoxib and celecoxib with warfarin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030701

Title: Nonsteroidal antiinflammatory drug starter packs for chronic musculoskeletal pain.

Journal: Pharmacotherapy 20020701

Title: Blood pressure elevation in a patient treated with salsalate.

Journal: The Annals of pharmacotherapy 20020401

Title: Cutaneous drug reaction case reports: from the world literature.

Journal: American journal of clinical dermatology 20020101

Title: Lichenoid drug eruption to salsalate.

Journal: Journal of the American Academy of Dermatology 20011001

Title: Modulation of endothelial cell activation in sickle cell disease: a pilot study.

Journal: Blood 20010401

Title: Murthy SN, et al. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats. Diabetes. 2010;59(12):3240-3246.

Title: Scheiman JM, et al. Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans. Semin Arthritis Rheum. 1990;20(2):121-127.

Title: González F, et al. Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2020;319(4):E744-E752.

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