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55297-95-5,MFCD00864839
Catalog No.:AA00I9SC

55297-95-5 | Tiamulin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$75.00   $53.00
- +
25mg
95%
in stock  
$150.00   $105.00
- +
100mg
analytical standard
in stock  
$365.00   $255.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9SC
Chemical Name:
Tiamulin
CAS Number:
55297-95-5
Molecular Formula:
C28H47NO4S
Molecular Weight:
493.7421
MDL Number:
MFCD00864839
SMILES:
CCN(CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@@H]([C@]23[C@H]([C@@]1(C)[C@H](C)CC2)C(=O)CC3)C)CC
Properties
Properties
 
BP:
563°C at 760 mmHg  
Form:
Solid  
MP:
147.5℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
770  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
5.6  

Literature

Title: Design, synthesis, and antibacterial activity of novel pleuromutilin derivatives bearing an amino thiazolyl ring.

Journal: Archiv der Pharmazie 20120801

Title: [Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

Title: Pleuromutilin and its derivatives-the lead compounds for novel antibiotics.

Journal: Mini reviews in medicinal chemistry 20120101

Title: Determination of minimum inhibitory and minimum bactericidal concentrations of tiamulin against field isolates of Actinobacillus pleuropneumoniae.

Journal: Veterinary microbiology 20110805

Title: Decreased susceptibility of MRSA ST398 to tiamulin.

Journal: Veterinary microbiology 20110805

Title: Change in antimicrobial susceptibility of Mycoplasma gallisepticum field isolates.

Journal: Veterinary microbiology 20110602

Title: Assessment of the antihistomonal effect of paromomycin and tiamulin.

Journal: Tijdschrift voor diergeneeskunde 20110601

Title: Antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolates from clinical outbreaks of porcine respiratory diseases.

Journal: Veterinary microbiology 20110512

Title: Recurrence of Chlamydiasuis infection in pigs after short-term antimicrobial treatment.

Journal: Veterinary journal (London, England : 1997) 20110301

Title: Simultaneous determination of three classes of antibiotics in the suspended solids of swine wastewater by ultrasonic extraction, solid-phase extraction and liquid chromatography-mass spectrometry.

Journal: Journal of environmental sciences (China) 20110101

Title: Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum.

Journal: FEMS microbiology letters 20100701

Title: Factors influencing the activity of tiamulin against Histomonas meleagridis in vitro.

Journal: Avian diseases 20100601

Title: Tiamulin hydrogen fumarate--veterinary uses and HPLC method of determination in premixes and medicated feeding stuffs.

Journal: Acta poloniae pharmaceutica 20100101

Title: The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine--A review.

Journal: Poultry science 20091101

Title: Mutilins derivatives: from veterinary to human-used antibiotics.

Journal: Mini reviews in medicinal chemistry 20091001

Title: U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.

Journal: Journal of molecular biology 20090529

Title: Spironucleosis in gamebirds.

Journal: The Veterinary record 20090321

Title: Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.

Journal: Molecular microbiology 20090301

Title: Tiamulin activity against Brachyspira hyodysenteriae.

Journal: The Veterinary record 20081206

Title: Compatibility of a combination of tiamulin and chlortetracycline with salinomycin in feed during a pulsed medication program coadministration in broilers.

Journal: Poultry science 20081201

Title: Tiamulin activity against Brachyspira hyodysenteriae.

Journal: The Veterinary record 20081201

Title: A click chemistry approach to pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome.

Journal: Journal of medicinal chemistry 20080828

Title: Simultaneous determination of sulfonamides, tetracyclines and tiamulin in swine wastewater by solid-phase extraction and liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20080822

Title: Compatibility of a combination of tiamulin plus chlortetracycline with salinomycin in feed during a long-term co-administration in broilers.

Journal: Poultry science 20080801

Title: [Multiresistant Brachyspira hyodysenteriae in a Dutch sow herd].

Journal: Tijdschrift voor diergeneeskunde 20080701

Title: Treatment of histomonosis in turkeys with tiamulin.

Journal: The Veterinary record 20071201

Title: The effect of medicated diets and level of feeding on caecal microbiota of lactating rabbit does.

Journal: Journal of applied microbiology 20071001

Title: Effects of tiamulin, neomycin, tetracycline, fluorophenicol, penicillin G, Linco-Spectin, erythromycin and oxytetracycline on controlling bacterial contaminations of the river buffalo (Buballus bubalis) semen.

Journal: Pakistan journal of biological sciences : PJBS 20070915

Title: The effect of lactating rabbit does on the development of the caecal microbial community in the pups they nurture.

Journal: Journal of applied microbiology 20070901

Title: Susceptibility of bacteria isolated from pigs to tiamulin and enrofloxacin metabolites.

Journal: Veterinary microbiology 20070331

Title: Persistence of antibiotics such as macrolides, tiamulin and salinomycin in soil.

Journal: Environmental pollution (Barking, Essex : 1987) 20061001

Title: Isolation and structural elucidation of tiamulin metabolites formed in liver microsomes of pigs.

Journal: Journal of pharmaceutical and biomedical analysis 20060918

Title: Elimination of macrolides, tiamulin, and salinomycin during manure storage.

Journal: Archives of environmental contamination and toxicology 20060701

Title: Treatment of a field case of avian intestinal spirochaetosis caused by Brachyspira pilosicoli with tiamulin.

Journal: Avian pathology : journal of the W.V.P.A 20060601

Title: Trace analysis of tiamulin in honey by liquid chromatography-diode array-electrospray ionization mass spectrometry detection.

Journal: Journal of chromatography. A 20060526

Title: Tiamulin and semduramicin: effects of simultaneous administration on performance and health of growing broiler chickens.

Journal: Poultry science 20060301

Title: Tiamulin resistance in porcine Brachyspira pilosicoli isolates.

Journal: Research in veterinary science 20060201

Title: Evaluation of the therapeutic activity of tulathromycin against swine respiratory disease on farms in Europe.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin.

Journal: Molecular microbiology 20041201

Title: Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

Journal: Molecular microbiology 20041201

Title: Testing the efficacy of fermented wheat germ extract against Mycoplasma gallisepticum infection of chickens.

Journal: Poultry science 20041101

Title: Comparison of methods for antimicrobial susceptibility testing and MIC values for pleuromutilin drugs for Brachyspira hyodysenteriae isolated in Germany.

Journal: Veterinary microbiology 20040819

Title: Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin.

Journal: Journal of medical microbiology 20040401

Title: Decreased susceptibility to tiamulin and valnemulin among Czech isolates of Brachyspira hyodysenteriae.

Journal: Journal of medical microbiology 20040401

Title: Biochemical background of toxic interaction between tiamulin and monensin.

Journal: Chemico-biological interactions 20040315

Title: [The use of macrolides, lincomycin and tiamulin as animal feed drugs for pigs in Schleswig-Holstein].

Journal: Berliner und Munchener tierarztliche Wochenschrift 20040101

Title: Effects of the administration of spiramycin and tiamulin on in vivo complex formation and hepatic cytochrome P4503A (CYP3A)-dependent monooxygenases in rabbits.

Journal: Veterinary research communications 20030901

Title: Determination of antibiotics from soil by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20030627

Title: Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection.

Journal: Research in veterinary science 20030601

Title: Determination of antibiotics such as macrolides, ionophores and tiamulin in liquid manure by HPLC-MS/MS.

Journal: Analytical and bioanalytical chemistry 20030401

Title: Effects of the antibacterial agents tiamulin, olanquindox and metronidazole and the anthelmintic ivermectin on the soil invertebrate species Folsomia fimetaria (Collembola) and Enchytraeus crypticus (Enchytraeidae).

Journal: Chemosphere 20030101

Title: Screening method for detecting cross-contamination residues of tiamulin in swine feeds.

Journal: Journal of AOAC International 20030101

Title: In vitro formation of metabolic-intermediate cytochrome P450 complexes in rabbit liver microsomes by tiamulin and various macrolides.

Journal: Veterinary research 20030101

Title: Reduction of economic losses caused by mycoplasmal pneumonia of pigs by vaccination with Respisure and by Tiamutin treatment.

Journal: Acta veterinaria Hungarica 20030101

Title: In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae.

Journal: Veterinary microbiology 20020802

Title: Influence of in-feed zinc bacitracin and tiamulin treatment on experimental avian intestinal spirochaetosis caused by Brachyspira intermedia.

Journal: Avian pathology : journal of the W.V.P.A 20020601

Title: Evaluation of tiamulin and lincomycin for the treatment of broiler breeders experimentally infected with the intestinal spirochaete Brachyspira pilosicoli.

Journal: Avian pathology : journal of the W.V.P.A 20020601

Title: Simultaneous determination of various macrolides by liquid chromatography/mass spectrometry.

Journal: Journal of veterinary science 20020601

Title: Determination of tiamulin in type C medicated swine feeds using high throughput extraction with liquid chromatography.

Journal: Journal of AOAC International 20020101

Title: An assessment of antimicrobial consumption in food producing animals in Kenya.

Journal: Journal of veterinary pharmacology and therapeutics 20011201

Title: The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome.

Journal: Molecular microbiology 20010901

Title: Eradication of endemic Brachyspira pilosicoli infection from a farrowing herd: a case report.

Journal: Animal health research reviews 20010601

Title: Susceptibility to pleuromutilins in Brachyspira (Serpulina) hyodysenteriae.

Journal: Animal health research reviews 20010601

Title: Intestinal spirochete infections of chickens: a review of disease associations, epidemiology and control.

Journal: Animal health research reviews 20010601

Title: Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

Journal: Bioorganic & medicinal chemistry 20010501

Title: An investigation of the etiology of a mild diarrhea observed in a group of grower/finisher pigs.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20010101

Title: Proposed quality control guidelines for National Committee for Clinical Laboratory Standards Susceptibility Tests using the veterinary antimicrobial agent tiamulin.

Journal: Diagnostic microbiology and infectious disease 20010101

Title: Noa M, et al. Tiamulin-nitrovin interaction in pigs: a case report and experimental reproduction. Vet Hum Toxicol. 2000 Oct;42(5):286-8.

Title: Dreyfuss J, et al. Metabolism of tritium- and carbon-14-labeled tiamulin in dogs, rats, and pigs. J Antibiot (Tokyo). 1979 May;32(5):496-503.

Title: Islam KM, et al. The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine--A review. Poult Sci. 2009 Nov;88(11):2353-9.

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