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56100-42-6,MFCD31630799
Catalog No.:AA01EOOY

56100-42-6 | l-Atabrine dihydrochloride

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Purity
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5mg
98%
1 week  
$111.00   $78.00
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10mg
98%
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$146.00   $102.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOOY
Chemical Name:
l-Atabrine dihydrochloride
CAS Number:
56100-42-6
Molecular Formula:
C23H32Cl3N3O
Molecular Weight:
472.8787
MDL Number:
MFCD31630799
SMILES:
CCN(CCC[C@H](Nc1c2cc(OC)ccc2nc2c1ccc(c2)Cl)C)CC.Cl.Cl
Properties
Computed Properties
 
Complexity:
461  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation.

Journal: Toxicology and applied pharmacology 20171101

Title: Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and β catenin through activation of GSK3β.

Journal: Toxicology and applied pharmacology 20170901

Title: N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.

Journal: ChemMedChem 20140201

Title: Inhibition of platelet-mediated arterial thrombosis and platelet granule exocytosis by 3',4'-dihydroxyflavonol and quercetin.

Journal: Platelets 20130101

Title: Prion inhibition with multivalent PrPSc binding compounds.

Journal: Biomaterials 20121001

Title: A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases.

Journal: Journal of neuropathology and experimental neurology 20120501

Title: Single yeast cell vacuolar milieu viscosity assessment by fluorescence polarization microscopy with computer image analysis.

Journal: Yeast (Chichester, England) 20120501

Title: Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin.

Journal: European journal of pharmacology 20120415

Title: Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity.

Journal: International journal of cancer 20120401

Title: Impact of smoking in cutaneous lupus erythematosus.

Journal: Archives of dermatology 20120301

Title: Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

Journal: Omics : a journal of integrative biology 20120101

Title: Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium.

Journal: BMC neuroscience 20120101

Title: Quinacrine induced mood disturbance--the unmasking of bipolar affective disorder.

Journal: BMJ case reports 20120101

Title: Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.

Journal: PloS one 20120101

Title: Release of ATP from marginal cells in the cochlea of neonatal rats can be induced by changes in extracellular and intracellular ion concentrations.

Journal: PloS one 20120101

Title: Oligonucleotide stabilized silver nanoclusters as fluorescence probe for drug-DNA interaction investigation.

Journal: Analytica chimica acta 20111114

Title: Response to antimalarial agents in cutaneous lupus erythematosus: a prospective analysis.

Journal: Archives of dermatology 20111101

Title: Practice Gaps. Optimizing antimalarial therapy for cutaneous lupus erythematosus: comment on 'Response to antimalarial agents in cutaneous lupus erythematosus'.

Journal: Archives of dermatology 20111101

Title: Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents.

Journal: Cancer biology & therapy 20110801

Title: Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer.

Journal: Cancer biology & therapy 20110801

Title: Quinacrine and 9-amino acridine inhibit B-Z and B-H(l) form DNA conformational transitions.

Journal: DNA and cell biology 20110701

Title: Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.

Journal: European journal of medicinal chemistry 20110701

Title: 2,4-diarylthiazole antiprion compounds as a novel structural class of antimalarial leads.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.

Journal: Neurotoxicity research 20110501

Title: Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110415

Title: Release of ATP from avian Müller glia cells in culture.

Journal: Neurochemistry international 20110201

Title: Mepacrine treatment attenuates allergic airway remodeling segregated from airway inflammation in mice.

Journal: International immunopharmacology 20110101

Title: A lytic mechanism based on soluble phospholypases A2 (sPLA2) and β-galactoside specific lectins is exerted by Ciona intestinalis (ascidian) unilocular refractile hemocytes against K562 cell line and mammalian erythrocytes.

Journal: Fish & shellfish immunology 20110101

Title: Hospitalization of Cuban children for giardiasis: a retrospective study in a paediatric hospital in Havana.

Journal: Annals of tropical medicine and parasitology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells.

Journal: Mutation research 20101029

Title: Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Journal: Antimicrobial agents and chemotherapy 20100901

Title: Osseous metaplasia late in the course of nephrogenic systemic fibrosis.

Journal: Dermatology online journal 20100815

Title: Activation of phospholipase D involved in both injury and survival in A549 alveolar epithelial cells exposed to H2O2.

Journal: Toxicology letters 20100715

Title: Emergence and natural selection of drug-resistant prions.

Journal: Molecular bioSystems 20100715

Title: Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin.

Journal: The Journal of biological chemistry 20100618

Title: A brief history of malaria chemotherapy.

Journal: The journal of the Royal College of Physicians of Edinburgh 20100601

Title: Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent.

Journal: Neuro-oncology 20100501

Title: Effect of Ca2+ on programmed death of guard and epidermal cells of pea leaves.

Journal: Biochemistry. Biokhimiia 20100501

Title: A lifetime cancer bioassay of quinacrine administered into the uterine horns of female rats.

Journal: Regulatory toxicology and pharmacology : RTP 20100301

Title: Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography.

Journal: Bioconjugate chemistry 20100217

Title: The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release.

Journal: Anesthesia and analgesia 20100201

Title: Development of a novel large animal model of ischemic heart failure using autologous platelet aggregates.

Journal: The International journal of artificial organs 20100201

Title: [Quinacrine in the treatment of cutaneous lupus erythematosus: practical aspects and a case series].

Journal: Actas dermo-sifiliograficas 20100101

Title: Loss of heart phospholipid arachidonic acid without phospholipid peroxidation in anaesthetized rats rewarmed after prolonged deep hypothermia.

Journal: Cryobiology 20091201

Title: Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20091201

Title: Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds.

Journal: ChemMedChem 20091201

Title: Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

Journal: Cell cycle (Georgetown, Tex.) 20091201

Title: Continuous quinacrine treatment results in the formation of drug-resistant prions.

Journal: PLoS pathogens 20091101

Title: Binding of TCA to the prion protein: mechanism, implication for therapy, and application as probe for complex formation of bio-macromolecules.

Journal: Journal of biomolecular structure & dynamics 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.

Journal: American journal of physiology. Lung cellular and molecular physiology 20090901

Title: Quinacrine protects neuronal cells against heat-induced injury.

Journal: Cell biology international 20090801

Title: [Systematic review of the therapeutics for prion diseases].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20090801

Title: Treatment of lupus skin involvement with quinacrine and hydroxychloroquine.

Journal: Lupus 20090701

Title: Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.

Journal: PLoS neglected tropical diseases 20090701

Title: Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity.

Journal: Archives of toxicology 20090601

Title: Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.

Journal: The Journal of antimicrobial chemotherapy 20090601

Title: Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat.

Journal: Molecules and cells 20090430

Title: Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401

Title: Clinical trials for prion disease: difficult challenges, but hope for the future.

Journal: The Lancet. Neurology 20090401

Title: Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial.

Journal: The Lancet. Neurology 20090401

Title: Unusual hydrate stabilization in the two-dimensional layered structure of quinacrinium bis(2-carboxy-4,5-dichlorobenzoate) tetrahydrate, a proton-transfer compound of the drug quinacrine.

Journal: Acta crystallographica. Section C, Crystal structure communications 20090401

Title: STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells.

Journal: Experimental & molecular medicine 20090227

Title: An EGF-like peptide sequence from Dictyostelium enhances cell motility and chemotaxis.

Journal: Biochemical and biophysical research communications 20090206

Title: Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA).

Journal: Neurochemical research 20090201

Title: Inhibition of RNA recruitment and replication of an RNA virus by acridine derivatives with known anti-prion activities.

Journal: PloS one 20090101

Title: Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.

Journal: Cellular and molecular neurobiology 20081101

Title: Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion.

Journal: Journal of applied toxicology : JAT 20081001

Title: Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells.

Journal: Gastroenterology 20080801

Title: The three-dimensional hydrogen-bonded framework structure in the 1:1 proton-transfer compound of the drug quinacrine with 5-sulfosalicylic acid.

Journal: Acta crystallographica. Section C, Crystal structure communications 20080801

Title: Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine.

Journal: Fundamental & clinical pharmacology 20080801

Title: Antiprion activity of functionalized 9-aminoacridines related to quinacrine.

Journal: Bioorganic & medicinal chemistry 20080715

Title: [Metalloproteinases. Structure and function].

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20080703

Title: The collecting duct is the major source of prorenin in diabetes.

Journal: Hypertension (Dallas, Tex. : 1979) 20080601

Title: Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.

Journal: International immunopharmacology 20080601

Title: Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20080501

Title: A multimeric quinacrine conjugate as a potential inhibitor of Alzheimer's beta-amyloid fibril formation.

Journal: Chembiochem : a European journal of chemical biology 20080414

Title: Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells.

Journal: Journal of neurochemistry 20080401

Title: Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein.

Journal: Bioorganic & medicinal chemistry 20080401

Title: Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway.

Journal: The Journal of infection 20080401

Title: Sub-micromolar increase in [Ca(2+)](i) triggers delayed exocytosis of ATP in cultured astrocytes.

Journal: Glia 20080101

Title: Mepacrine antagonises tumour cell growth induced by natural polyamines.

Journal: Anticancer research 20080101

Title: Use of protease inhibitors for detecting autophagy in plants.

Journal: Methods in enzymology 20080101

Title: Histamine in Macaca mulatto monkey cardiac sympathetic nerve system: a morphological and functional assessment.

Journal: Autonomic neuroscience : basic & clinical 20071230

Title: RNA targeting by DNA binding drugs: structural, conformational and energetic aspects of the binding of quinacrine and DAPI to A-form and H(L)-form of poly(rC).poly(rG).

Journal: Biochimica et biophysica acta 20071201

Title: Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.

Journal: European journal of pharmacology 20071001

Title: Polyphenols modulate calcium-independent mechanisms in human arterial tissue-engineered vascular media.

Journal: Journal of vascular surgery 20071001

Title: Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.

Journal: Bulletin of experimental biology and medicine 20071001

Title: Exocytotic release of ATP from cultured astrocytes.

Journal: The Journal of biological chemistry 20070928

Title: Role of phospholipase D2 in anti-apoptotic signaling through increased expressions of Bcl-2 and Bcl-xL.

Journal: Journal of cellular biochemistry 20070815

Title: Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells.

Journal: Endocrine journal 20070801

Title: Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation.

Journal: European journal of immunology 20070801

Title: [Prophylactic effect of quinacrine against experimental heatstroke].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070801

Title: Involvement of free radicals followed by the activation of phospholipase A2 in the mechanism that underlies the combined effects of methamphetamine and morphine on subacute toxicity or lethality in mice: comparison of the therapeutic potential of fullerene, mepacrine, and cooling.

Journal: Toxicology 20070717

Title: Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine.

Journal: Cellular and molecular neurobiology 20070501

Title: Cyanide-induced death of cells in plant leaves.

Journal: Biochemistry. Biokhimiia 20070501

Title: Effects of picolinic acid on the antimicrobial functions of host macrophages against Mycobacterium avium complex.

Journal: International journal of antimicrobial agents 20070401

Title: The effects of the glucocorticoid receptor antagonist RU486 and phospholipase A2 inhibitor quinacrine on acoustic injury of the mouse cochlea.

Journal: Neuroscience letters 20070208

Title: Phospholipase D1 as a key enzyme for decidualization in human endometrial stromal cells.

Journal: Biology of reproduction 20070201

Title: Oral given Mepacrine could increase the resistance to heat environment injury.

Journal: Medical hypotheses 20070101

Title: DNA cleavage induced by photoexcited antimalarial drugs: a photophysical and photobiological study.

Journal: Photochemistry and photobiology 20070101

Title: Effects of anti-malarial drugs on MCF-7 and Vero cell replication.

Journal: Anticancer research 20070101

Title: Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines.

Journal: International journal of toxicology 20070101

Title: Hydrogen peroxide increases [3H]-2-deoxyglucose uptake via MAPKs, cPLA2, and NF-kappaB signaling pathways in mouse embryonic stem cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

Title: Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.

Journal: International journal of toxicology 20070101

Title: Expression of ATP-gated P2X3 receptors in rat gustatory papillae and taste buds.

Journal: Archives of histology and cytology 20061201

Title: A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations.

Journal: Journal of medicinal chemistry 20061102

Title: Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children.

Journal: World journal of gastroenterology 20061021

Title: [The mechanism of ABA-induced apoplastic H2O2 accumulation in maize leaves].

Journal: Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology 20061001

Title: Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060901

Title: Activity of picolinic acid in combination with the antiprotozoal drug quinacrine against Mycobacterium avium complex.

Journal: Antimicrobial agents and chemotherapy 20060901

Title: Non-competitive inhibitory activities of morphinan and morphine derivatives at the alpha 3 beta 4 Neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques.

Journal: Pharmaceutical research 20060901

Title: Binding of anti-prion agents to glycosaminoglycans: evidence from electronic absorption and circular dichroism spectroscopy.

Journal: Biochemical and biophysical research communications 20060811

Title: Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments.

Journal: Journal of neurochemistry 20060801

Title: Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060701

Title: Characteristics of taurine release in slices from adult and developing mouse brain stem.

Journal: Amino acids 20060701

Title: Interactions of recombinant prions with compounds of therapeutical significance.

Journal: Biochemical and biophysical research communications 20060602

Title: Evaluation of the protective effects of quinacrine against Bacillus anthracis Ames.

Journal: Journal of toxicology and environmental health. Part A 20060601

Title: alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.

Journal: Cellular signalling 20060501

Title: The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus.

Journal: Scandinavian journal of immunology 20060401

Title: A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs. Influences of the surface properties of liposomes and the crosslinked fibrin network.

Journal: International journal of pharmaceutics 20060327

Title: Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition.

Journal: Organic & biomolecular chemistry 20060321

Title: Screening a library of potential prion therapeutics against cellular prion proteins and insights into their mode of biological activities by surface plasmon resonance.

Journal: Journal of pharmaceutical and biomedical analysis 20060303

Title: Estrogen induces phospholipase A2 activation through ERK1/2 to mobilize intracellular calcium in MCF-7 cells.

Journal: Steroids 20060301

Title: Quinacrine but not chloroquine inhibits PMA induced upregulation of matrix metalloproteinases in leukocytes: quinacrine acts at the transcriptional level through a PLA2-independent mechanism.

Journal: The Journal of rheumatology 20060301

Title: Blockade of arachidonic acid pathway induces sprouting in the adult but not in the neonatal uncrossed retinotectal projection.

Journal: Neuroscience 20060101

Title: A one-year neonatal mouse carcinogenesis study of quinacrine dihydrochloride.

Journal: International journal of toxicology 20060101

Title: Acridin-9-yl exchange: a proposal for the action of some 9-aminoacridine drugs.

Journal: Biopolymers 20060101

Title: The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome.

Journal: The Journal of membrane biology 20060101

Title: Creutzfeldt-Jakob disease acquired via a dural graft: failure of therapy with quinacrine and chlorpromazine.

Journal: Surgical neurology 20051201

Title: Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.

Journal: The Journal of experimental biology 20051201

Title: Phospholipase A(2) activity of beta-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons.

Journal: Journal of neurobiology 20050801

Title: Acridine derivatives activate p53 and induce tumor cell death through Bax.

Journal: Cancer biology & therapy 20050801

Title: Autocrine/paracrine stimulation of purinergic receptors in osteoblasts: contribution of vesicular ATP release.

Journal: Biochemical and biophysical research communications 20050617

Title: Re: Martin TJM, Sharp I, Oral mucosal pigmentation secondary to treatment with mepacrine, with sparing of the denture bearing area (Br J Oral Maxillofac Surg 2004;42:351-3).

Journal: The British journal of oral & maxillofacial surgery 20050601

Title: Increased superoxide production in hypertensive patients with diabetes mellitus: role of nitric oxide synthase.

Journal: American journal of hypertension 20050601

Title: Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effects.

Journal: Neurology 20050524

Title: Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.

Journal: European journal of pharmacology 20050509

Title: PGE(2) in the regulation of programmed erythrocyte death.

Journal: Cell death and differentiation 20050501

Title: Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis.

Journal: Biophysical journal 20050301

Title: Endosomal proteases facilitate the fusion of endosomes with vacuoles at the final step of the endocytotic pathway.

Journal: The Plant journal : for cell and molecular biology 20050301

Title: Altered interaction and expression of proteins involved in neurosecretion in scrapie-infected GT1-1 cells.

Journal: The Journal of biological chemistry 20050114

Title: Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats.

Journal: Neurotoxicology 20050101

Title: Transcervical polidocanol as a nonsurgical method of female sterilization: a pilot study.

Journal: Contraception 20050101

Title: Rhabdomyolysis associated with quinacrine therapy in a patient with chronic cutaneous lupus erythematosus.

Journal: Journal of drugs in dermatology : JDD 20050101

Title: Papular elastolytic giant cell granuloma responding to hydroxychloroquine and quinacrine.

Journal: International journal of dermatology 20041201

Title: Inflammatory parameters after pleurodesis in recurrent malignant pleural effusions and their predictive value.

Journal: Respiratory medicine 20041201

Title: The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets.

Journal: Journal of thrombosis and haemostasis : JTH 20041201

Title: Toxicity of quinacrine can be reduced by co-administration of P-glycoprotein inhibitor in sporadic Creutzfeldt-Jakob disease.

Journal: Cellular and molecular neurobiology 20041201

Title: Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.

Journal: The Journal of biological chemistry 20041119

Title: [Systemic lupus erythematosus therapy. Antimalarials in inflammatory diseases].

Journal: Revista clinica espanola 20041101

Title: Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.

Journal: European journal of pharmacology 20040919

Title: The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs.

Journal: Annals of tropical medicine and parasitology 20040901

Title: Scar sarcoidosis following tattooing of the lips treated with mepacrine.

Journal: Clinical and experimental dermatology 20040901

Title: Oral mucosal pigmentation secondary to treatment with mepacrine, with sparing of the denture bearing area.

Journal: The British journal of oral & maxillofacial surgery 20040801

Title: Effect of uncouplers on endogenous respiration and ferrous iron oxidation in a chemolithoautotrophic bacterium Acidithiobacillus (Thiobacillus) ferrooxidans.

Journal: FEMS microbiology letters 20040801

Title: Rapid vitamin D-dependent PKC signaling shares features with estrogen-dependent PKC signaling in cartilage and bone.

Journal: Steroids 20040801

Title: Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design.

Journal: The Journal of biological chemistry 20040709

Title: Species identification after treatment for taeniasis.

Journal: Lancet (London, England) 20040612

Title: [Creutzfeldt-Jakob disease, Heidenhain variant: case report with MRI (DWI) findings].

Journal: Arquivos de neuro-psiquiatria 20040601

Title: Inhibitors of the K+(Na+)/H+ exchanger of human red blood cells.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20040501

Title: BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2.

Journal: Methods and findings in experimental and clinical pharmacology 20040501

Title: Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines.

Journal: Biochemistry 20040420

Title: Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.

Journal: Cellular and molecular neurobiology 20040401

Title: Bull's-eye maculopathy associated with quinacrine therapy for malaria.

Journal: American journal of ophthalmology 20040301

Title: Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions.

Journal: Photochemistry and photobiology 20040301

Title: Structure-activity relationships for the 9-(pyridin-2'-yl)- aminoacridines.

Journal: Molecules (Basel, Switzerland) 20040227

Title: Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment.

Journal: Neurobiology of disease 20040201

Title: PLA2/PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin-(1-7)-stimulated Na(+)-ATPase activity of the proximal tubule.

Journal: Regulatory peptides 20040115

Title: Pleurodesis for malignant pleural effusions.

Journal: The Cochrane database of systematic reviews 20040101

Title: Antimalarial lichenoid tissue reactions in patients with pre-existing lupus erythematosus.

Journal: Lupus 20040101

Title: Combined quinacrine and chlorpromazine therapy in fatal familial insomnia.

Journal: Clinical neuropharmacology 20040101

Title: Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment.

Journal: Experimental lung research 20040101

Title: Pharmacokinetics of quinacrine in the treatment of prion disease.

Journal: BMC infectious diseases 20040101

Title: Quinacrine blocks PrP (106-126)-formed channels.

Journal: Journal of neuroscience research 20031215

Title: Mepacrine inhibits matrix metalloproteinases-1 (MMP-1) and MMP-9 activation in human fibroblast-like synoviocytes.

Journal: The Journal of rheumatology 20031101

Title: [Therapeutics for prion diseases].

Journal: Rinsho shinkeigaku = Clinical neurology 20031101

Title: Fluorescent labeling of yeast.

Journal: Current protocols in cell biology 20031101

Title: Advanced glycation end products stimulate an enhanced neutrophil respiratory burst mediated through the activation of cytosolic phospholipase A2 and generation of arachidonic Acid.

Journal: Circulation 20031014

Title: Lipid metabolism in the cockroach, Periplaneta americana, is activated by the hypertrehalosemic peptide, HTH-I.

Journal: Peptides 20031001

Title: Quinacrine sterilization: a retrospective.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20031001

Title: Quinacrine sterilization (QS) among high-risk women: a study of 134 cases.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20031001

Title: A 22-year experience with quinacrine sterilization in a rural private clinic in Midnapore, India: a report on 5 protocols and 1838 cases.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20031001

Title: Marie Stopes Society, Pakistan: 1000 cases of quinacrine sterilization (QS).

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20031001

Title: 10-year follow-up of women who elected quinacrine sterilization (QS) in Wonosobo, Central Java, Indonesia.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20031001

Title: Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells.

Journal: The Journal of biological chemistry 20030905

Title: Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.

Journal: Journal of medicinal chemistry 20030814

Title: [Quinacrine administration to a patient with Creutzfeldt-Jakob disease who received a cadaveric dura mater graft--an EEG evaluation].

Journal: Rinsho shinkeigaku = Clinical neurology 20030701

Title: Differential inhibition of prion propagation by enantiomers of quinacrine.

Journal: Laboratory investigation; a journal of technical methods and pathology 20030601

Title: Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities.

Journal: Bioorganic & medicinal chemistry 20030515

Title: Quinacrine-induced cytolytic hepatitis in sporadic Creutzfeldt-Jakob disease.

Journal: Annals of neurology 20030401

Title: Role of intracellular Ca2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries.

Journal: Life sciences 20030307

Title: Renal effects of supernatant from rat peritoneal macrophages activated by microcystin-LR: role protein mediators.

Journal: Toxicon : official journal of the International Society on Toxinology 20030301

Title: Long-term staining of live Merkel cells with FM dyes.

Journal: Cell and tissue research 20030301

Title: Aqueous access channels in subunit a of rotary ATP synthase.

Journal: The Journal of biological chemistry 20030221

Title: Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury.

Journal: Experimental brain research 20030201

Title: Searching for mechanisms of N-methyl-D-aspartate-induced glutathione efflux in organotypic hippocampal cultures.

Journal: Neurochemical research 20030201

Title: Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.

Journal: European journal of biochemistry 20030101

Title: Effects of cholesterol on dye leakage induced by multidrug-resistance modulators from anionic liposomes.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030101

Title: Quinacrine added to ongoing therapeutic regimens attenuates anticardiolipin antibody production in SLE.

Journal: Lupus 20030101

Title: Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2.

Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20030101

Title: Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury.

Journal: Neuroscience 20030101

Title: Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: potency of responses and relationship to slipped mispairing models.

Journal: Environmental and molecular mutagenesis 20030101

Title: [Effect of forskolin and quinacrine on leukocyte functions under the effect of low-dose radiation].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

Title: Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20021201

Title: Quinacrine enhances vesicular stomatitis virus inactivation and diminishes hemolysis of dimethylmethylene blue-phototreated red cells.

Journal: Photochemistry and photobiology 20021101

Title: Mechanism of silica-induced ROS generation in Rat2 fibroblast cells.

Journal: Toxicology letters 20021005

Title: Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2.

Journal: The Biochemical journal 20020815

Title: Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells.

Journal: Clinical and experimental pharmacology & physiology 20020701

Title: Surgical manipulation of the small intestine and its effect on the lung.

Journal: The Journal of surgical research 20020701

Title: Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay.

Journal: Mutation research 20020619

Title: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.

Journal: Biochemical pharmacology 20020615

Title: alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry 20020531

Title: Randomized trial of one versus two transcervical insertions of quinacrine pellets for sterilization.

Journal: Fertility and sterility 20020501

Title: Quantal release of free radicals during exocytosis of phagosomes.

Journal: Nature cell biology 20020401

Title: 4-Bromophenacyl bromide induces Ca2+ influx in human gingival fibroblasts.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020301

Title: Cutaneous involvement of dermatomyositis can respond to Dapsone therapy.

Journal: International journal of dermatology 20020301

Title: The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine.

Journal: Biochemical pharmacology 20020215

Title: Quinacrine increases endothelial nitric oxide release: role of superoxide anion.

Journal: European journal of pharmacology 20020202

Title: Arachidonic acid release from rat Leydig cells: the involvement of G protein, phospholipase A2 and regulation of cAMP production.

Journal: The Journal of endocrinology 20020101

Title: [Larvicidal activity of acrichine and dabechine injected into a hydatid cyst by electrophoresis: experimental study].

Journal: Meditsinskaia parazitologiia i parazitarnye bolezni 20020101

Title: Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse.

Journal: Biological research 20020101

Title: Shear-induced platelet activation and adhesion on human pulmonary artery endothelial cells seeded onto hydrophilic polymers.

Journal: Journal of biomedical materials research 20011205

Title: Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular.

Journal: Journal of cardiovascular pharmacology 20011201

Title: Effect of quinacrine treatment on the activity of acid hydrolases (phosphatase, N-acetyl-beta-glucosaminidase, glucosidase, galactosidase and esterase) in Tetrahymena.

Journal: Cell biochemistry and function 20011201

Title: Antigiardial drugs.

Journal: Applied microbiology and biotechnology 20011201

Title: Present trends and future strategy in chemotherapy of malaria.

Journal: Current medicinal chemistry 20011101

Title: Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1.

Journal: Molecular microbiology 20011101

Title: Quinacrine non-surgical female sterilization in Bangladesh.

Journal: Contraception 20011101

Title: Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.

Journal: Bioorganic & medicinal chemistry letters 20011008

Title: Quinacrine enhances carmustine therapy of experimental rat glioma.

Journal: Neurosurgery 20011001

Title: Reversible redox control of plant vacuolar H+-ATPase activity is related to disulfide bridge formation in subunit E as well as subunit A.

Journal: The Plant journal : for cell and molecular biology 20011001

Title: Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.

Journal: Journal of neuroscience research 20010915

Title: Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.

Journal: Structure (London, England : 1993) 20010901

Title: The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors.

Journal: Molecular pharmacology 20010801

Title: Phospholipase A(2)--derived neutral lipids from posthemorrhagic shock mesenteric lymph prime the neutrophil oxidative burst.

Journal: Surgery 20010801

Title: Two phenanthraquinones from Dendrobium moniliforme.

Journal: Journal of natural products 20010801

Title: [Increase of water permeability and recovery of water impermeability of the frog urinary bladder].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010801

Title: Multiple roles of the conserved key residue arginine 209 in neuronal nicotinic receptors.

Journal: Biochemistry 20010727

Title: Role of the cytosolic phospholipase A2-linked cascade in signaling by an oncogenic, constitutively active Ha-Ras isoform.

Journal: The Journal of biological chemistry 20010706

Title: The phospholipase A2 inhibitor quinacrine prevents increased immunoreactivity to cytoplasmic phospholipase A2 (cPLA2) and hydroxynonenal (HNE) in neurons of the lateral septum following fimbria-fornix transection.

Journal: Experimental brain research 20010601

Title: Interleukin-1beta induces the expression of lipocortin 1 mRNA in cultured rat cortical astrocytes.

Journal: Neuroscience research 20010501

Title: Nonsurgical female sterilization: comparison of intrauterine application of quinacrine alone or in combination with ibuprofen.

Journal: Fertility and sterility 20010401

Title: Diesel exhaust particle-induced cell death of human leukemic promyelocytic cells HL-60 and their variant cells HL-NR6.

Journal: Biological & pharmaceutical bulletin 20010401

Title: Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells.

Journal: Archives of pharmacal research 20010401

Title: Effects of two newly synthesized analogues of lidocaine on rat arterial blood pressure and heart rate.

Journal: Pharmacological research 20010401

Title: Formyl-methionyl-leucyl-phenylalanine induces prostaglandin E2 release from human amnion-derived WISH cells by phospholipase C-mediated [Ca+]i rise.

Journal: Biology of reproduction 20010301

Title: ATP-induced mucin release from cultured airway goblet cell involves, in part, activation of phospholipase A2.

Journal: Methods and findings in experimental and clinical pharmacology 20010301

Title: Treatment of Giardia lamblia infections.

Journal: The Pediatric infectious disease journal 20010201

Title: Current treatment of cutaneous lupus erythematosus.

Journal: Dermatology online journal 20010201

Title: Neutrophil-mediated biodegradation of medical implant materials.

Journal: Journal of cellular physiology 20010101

Title: Interdependence between sodium transport, external chloride, and sodium/calcium exchanger in the isolated skin of the Rana pipiens.

Journal: The Journal of experimental zoology 20010101

Title: Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents.

Journal: Brain research bulletin 20010101

Title: Cell attachment to extracellular matrices is modulated by pulsed radiation at 820 nm and chemicals that modify the activity of enzymes in the plasma membrane.

Journal: Lasers in surgery and medicine 20010101

Title: Understanding channel blocking in the nicotinic acetylcholine receptor.

Journal: Receptors & channels 20010101

Title: The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cells.

Journal: Brain tumor pathology 20010101

Title: Inhibition of HIV-1 Tat-mediated transactivation by quinacrine and chloroquine.

Journal: Biochemical and biophysical research communications 19960904

Title: Drug metabolizing enzyme induction by benzoquinolines, acridine, and quinacrine; tricyclic aromatic molecules containing a single heterocyclic nitrogen.

Journal: Journal of biochemical toxicology 19960101

Title: The association of the two antimalarials chloroquine and quinacrine for treatment-resistant chronic and subacute cutaneous lupus erythematosus.

Journal: Dermatology (Basel, Switzerland) 19940101

Title: HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids.

Journal: Journal of medicinal chemistry 19920724

Title: Dose-dependent enhancing effects of quinacrine on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in male F344 rats.

Journal: Carcinogenesis 19911001

Title: Characterization of distinct phospholipases mediating bradykinin and noradrenaline hyperalgesia.

Journal: Neuroscience 19900101

Title: Marrow transplantation for severe aplastic anemia associated with exposure to quinacrine.

Journal: Blut 19900101

Title: Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats.

Journal: Life sciences 19870810

Title: Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19870101

Title: Parallel studies of His-DTrp-Ala-Trp-DPhe-Lys-NH2 and human pancreatic growth hormone-releasing factor-44-NH2 in rat primary pituitary cell monolayer culture.

Journal: Endocrinology 19850301

Title: Atrial thrombosis involving the heart of F-344 rats ingesting quinacrine hydrochloride.

Journal: Archives of toxicology 19841101

Title: Toxic psychosis following use of quinacrine.

Journal: The Journal of clinical psychiatry 19810401

Title: Quinacrine hydrochloride pellets: preliminary data on a nonsurgical method of female sterilization.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 19800101

Title: Experimental myopathy induced by amphiphilic cationic compounds including several psychotropic drugs.

Journal: Neuroscience 19790101

Title: Antiviral activity and induction of interferon-like substance by quinacrine and acranil.

Journal: Antimicrobial agents and chemotherapy 19730501

Title: Single-dose quinacrine (atabrine) and thoracostomy in the control of pleural effusions in patients with neoplastic diseases.

Journal: Cancer 19730401

Title: Ryou C, et al. Differential inhibition of prion propagation by enantiomers of quinacrine. Lab Invest. 2003 Jun;83(6):837-43.

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Tags:56100-42-6 Molecular Formula|56100-42-6 MDL|56100-42-6 SMILES|56100-42-6 l-Atabrine dihydrochloride