Home Amines 56796-39-5
56796-39-5,MFCD00214260
Catalog No.:AA00IA1L

56796-39-5 | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-

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Purity
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250mg
>97.0%(T)
in stock  
$120.00   $84.00
- +
1g
860 to 1003 µg/mg as anhydrous Cefmetazole [C15H17N7O5S3]
in stock  
$152.00   $107.00
- +
5g
860 to 1003 µg/mg as anhydrous Cefmetazole [C15H17N7O5S3]
in stock  
$482.00   $337.00
- +
25g
860 to 1003 µg/mg as anhydrous Cefmetazole [C15H17N7O5S3]
in stock  
$1,865.00   $1,306.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IA1L
Chemical Name:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-
CAS Number:
56796-39-5
Molecular Formula:
C15H16N7NaO5S3
Molecular Weight:
493.5162
MDL Number:
MFCD00214260
SMILES:
N#CCSCC(=O)N[C@]1(OC)C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])CSc1nnnn1C.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
>130°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
824  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  

Literature

Title: Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage.

Journal: Journal of gastroenterology 20111201

Title: Pyogenic cervical spondylitis caused by Pasteurella haemolytica attributed to excessive contact with dogs.

Journal: Orthopedics 20111109

Title: [The clinical efficacy and safety of intravenous cefmetazole in treatment of 1,522 patients with aspiration pneumonia].

Journal: Zhonghua nei ke za zhi 20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Multicenter prospective randomized phase II study of antimicrobial prophylaxis in low-risk patients undergoing colon surgery.

Journal: Surgery today 20101001

Title: Implementing a standard protocol to decrease the incidence of surgical site infections in rectal cancer surgery.

Journal: Surgery today 20100401

Title: Xanthogranulomatous pyelonephritis successfully treated with antibiotics only.

Journal: Journal of the Chinese Medical Association : JCMA 20081201

Title: Chimeric mice with humanized liver.

Journal: Toxicology 20080403

Title: Change of drug excretory pathway by CCl4-induced liver dysfunction in rat.

Journal: Biochemical pharmacology 20070801

Title: [Fundamental study on the selection of antimicrobial prophylactic agents in abdominal surgery].

Journal: The Japanese journal of antibiotics 20070801

Title: Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.

Journal: Archives of surgery (Chicago, Ill. : 1960) 20070701

Title: Humanization of excretory pathway in chimeric mice with humanized liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070601

Title: Effects of air tourniquet on the antibiotics concentration, in bone marrow, injected just before the start of operation.

Journal: Modern rheumatology 20070101

Title: [Prophylactic effect of fosfomycin on postoperative infection in gastroenterological surgery].

Journal: The Japanese journal of antibiotics 20061201

Title: Verification of cefmetazole and cefpodoxime proxetil contamination to other pharmaceuticals by liquid chromatography-tandem mass spectrometry.

Journal: Chemical & pharmaceutical bulletin 20061001

Title: LC/MS/MS method for the determination of trace amounts of cefmetazole and cefpodoxime proxetil contaminants in pharmaceutical manufacturing environments.

Journal: Journal of pharmaceutical and biomedical analysis 20060616

Title: Determination of cefmetazole residue at pharmaceutical manufacturing facilities by chemiluminescence flow injection analysis.

Journal: Journal of pharmaceutical and biomedical analysis 20060503

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Surveillance of susceptibility of clinical isolates to cefmetazole between 2000 and 2003].

Journal: The Japanese journal of antibiotics 20050601

Title: Infections of cefotaxime-resistant and cefmetazole-susceptible Escherichia coli and Klebsiella pneumoniae in children.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20050401

Title: The significance of the intraoperative repeated dosing of antimicrobials for preventing surgical wound infection in colorectal surgery.

Journal: Surgery today 20050101

Title: [Feasibility of short-term antibiotic prophylaxis after pulmonary resection].

Journal: Kyobu geka. The Japanese journal of thoracic surgery 20041201

Title: [A case of radiofrequency ablation therapy for recurrent hepatomas with tumor fever--efficacy of hepatic arterial infusion therapy with antibiotics and anticancer drugs].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20041001

Title: [Surveillance of susceptibility of clinical isolates to cefmetazole between 2000 and 2002].

Journal: The Japanese journal of antibiotics 20031201

Title: Intracystic hemorrhage with spontaneous rupture of liver cyst complicated by infection: a case report.

Journal: Osaka city medical journal 20031201

Title: [Antimicrobial activity of fosfomycin against beta-lactamase-producing methicillin-sensitive Staphylococcus aureus and methicillin-sensitive coagulase-negative staphylococci].

Journal: The Japanese journal of antibiotics 20030401

Title: [Antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha].

Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20030227

Title: [Successful combination therapy of teicoplanin with cefmetazole on postoperative cardiovascular MRSA infections: clinical report on two cases].

Journal: The Japanese journal of antibiotics 20030201

Title: Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics.

Journal: Oral microbiology and immunology 20021001

Title: Cefpirome sulphate for gynaecological infections and prophylaxis of non-laparotomy surgery in patients with benign disease.

Journal: International journal of antimicrobial agents 20020501

Title: Significance of SIRS score in therapeutic strategy for acute appendicitis.

Journal: Hepato-gastroenterology 20020101

Title: [Immunological properties of S-1090, cefmatilen hydrochloride hydrate].

Journal: The Journal of toxicological sciences 20010501

Title: Incidence of beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of orofacial odontogenic infections.

Journal: Oral microbiology and immunology 20010201

Title: MRSA meningitis in postoperative patients. Report of 4 cases.

Journal: The Japanese journal of antibiotics 19900601

Title: [A successful treatment of an infective endocarditis caused by methicillin-resistant Staphylococcus aureus with a combination of cefmetazole with fosfomycin].

Journal: The Japanese journal of antibiotics 19890901

Title: [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].

Journal: The Journal of toxicological sciences 19880601

Title: Myoclonic activity associated with cefmetazole, with a review of neurotoxicity of cephalosporins.

Journal: Clinical neurology and neurosurgery 19880101

Title: Antigenicity of beta-lactam antibiotic preparations: production of IgE antibodies to beta-lactam antibiotic and their cross-reaction within the antibiotic group.

Journal: International archives of allergy and applied immunology 19820101

Title: Truesdell SE, et, al. Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1989 Apr;23 Suppl D:13-9.

Title: Schentag JJ, et, al. Cefmetazole sodium: pharmacology, pharmacokinetics, and clinical trials. Pharmacotherapy. 1991;11(1):2-19.

Title: Yaguchi Y, et, al. Influences of long-term antibiotic administration on Peyer's patch lymphocytes and mucosal immunoglobulin A levels in a mouse model. JPEN J Parenter Enteral Nutr. 2006 Sep-Oct;30(5):395-8; discussion 399.

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Tags:56796-39-5 Molecular Formula|56796-39-5 MDL|56796-39-5 SMILES|56796-39-5 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-