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65899-73-2,MFCD00057276
Catalog No.:AA00IBGM

65899-73-2 | 1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

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1mg
98%
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$7.00   $5.00
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250mg
98%
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$21.00   $15.00
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1g
98%
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$27.00   $19.00
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5g
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$87.00   $61.00
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25g
98%
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$311.00   $218.00
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100g
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$1,009.00   $706.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IBGM
Chemical Name:
1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
CAS Number:
65899-73-2
Molecular Formula:
C16H13Cl3N2OS
Molecular Weight:
387.7112
MDL Number:
MFCD00057276
SMILES:
Clc1ccc(c(c1)Cl)C(Cn1ccnc1)OCc1ccsc1Cl
NSC Number:
759169
Properties
Properties
 
Form:
Solid  
MP:
79-81ºC  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
379  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.3  

Literature

Title: In vitro synergy testing of anidulafungin with fluconazole, tioconazole, 5-flucytosine and amphotericin B against some Candida spp.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701

Title: In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.

Journal: Antimicrobial agents and chemotherapy 20110201

Title: Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100601

Title: [Evaluation of susceptibility to antifungal agents of fungal strains isolated from pregnant women with diabetes and healthy pregnant women].

Journal: Ginekologia polska 20090401

Title: Molecular properties of oxyconazole and tioconazole as the criteria for their bioavailability estimation.

Journal: Acta poloniae pharmaceutica 20080101

Title: Molecular properties relevant to bioavailability of tioconazole and its derivatives.

Journal: Acta poloniae pharmaceutica 20080101

Title: Superficial cutaneous Trichosporon asahii infection in an immunocompetent host.

Journal: International journal of dermatology 20061201

Title: Onychoprotothecosis: report of the first case in Brazil.

Journal: International journal of dermatology 20060901

Title: Athlete's foot.

Journal: Clinical evidence 20051201

Title: Treatment costs of three nail lacquers used in onychomycosis.

Journal: The Journal of dermatological treatment 20050101

Title: In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis.

Journal: Chemotherapy 20041201

Title: Athlete's foot.

Journal: Clinical evidence 20041201

Title: Difference in percutaneous absorption and intracutaneous distribution in guinea pigs among topical antifungal drugs (tioconazole solution, tioconazole cream, miconazole nitrate solution and bifonazole solution).

Journal: Biological & pharmaceutical bulletin 20040901

Title: [A case of dystrophic fingernail].

Journal: Enfermedades infecciosas y microbiologia clinica 20040501

Title: A randomized comparison of nail surface remanence of three nail lacquers, containing amorolfine 5%, ciclopirox 8% or tioconazole 28%, in healthy volunteers.

Journal: International journal of tissue reactions 20040101

Title: Solubility of drugs in aqueous solutions. Part 3: multicomponent mixed solvent.

Journal: International journal of pharmaceutics 20031128

Title: Increase of activity of tioconazole against resistant microorganisms by the addition of butylated hydroxyanisole.

Journal: International journal of antimicrobial agents 20031001

Title: Ciclopiroxolamine: in vitro antifungal activity against clinical yeast isolates.

Journal: International journal of antimicrobial agents 20021101

Title: Effect of sub-MICs of antimycotics on expression of intracellular esterase of Trichophyton rubrum.

Journal: Medical mycology 20010201

Title: Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3-b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines.

Journal: Farmaco (Societa chimica italiana : 1989) 20000401

Title: Current and emerging azole antifungal agents.

Journal: Clinical microbiology reviews 19990101

Title: Antifungal activity of tioconazole (UK-20,349), a new imidazole derivative.

Journal: Antimicrobial agents and chemotherapy 19790401

Title: S P Clissold, et al. Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses. Drugs. 1986 Jan;31(1):29-51.

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Tags:65899-73-2 Molecular Formula|65899-73-2 MDL|65899-73-2 SMILES|65899-73-2 1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole