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57078-99-6,MFCD04115790
Catalog No.:AA00IA3T

57078-99-6 | 5-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)pentanoic acid

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Purity
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Price(USD)
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100mg
97%
in stock  
$51.00   $36.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IA3T
Chemical Name:
5-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)pentanoic acid
CAS Number:
57078-99-6
Molecular Formula:
C9H11NO4
Molecular Weight:
197.1879
MDL Number:
MFCD04115790
SMILES:
OC(=O)CCCCN1C(=O)C=CC1=O
Properties
Computed Properties
 
Complexity:
277  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
0.6  

Upstream Synthesis Route

[1]Synthesis,2008,#8,p.1316-1318

[2]BioorganicandMedicinalChemistryLetters,2008,vol.18,#22,p.5926-5931

[3]Tetrahedron,2012,vol.68,#16,p.3336-3341

[1]Patent:US2017/157262,2017,A1,

Downstream Synthesis Route

[1]Juarez-Hernandez,RalE.;Miller,PatriciaA.;Miller,MarvinJ.[ACSMedicinalChemistryLetters,2012,vol.3,#10,p.799-803]

[2]CurrentPatentAssignee:HANGZHOUDACBIOTECHCOLTD-US2017/157262,2017,A1Locationinpatent:Paragraph0206;0207

[3]CurrentPatentAssignee:HANGZHOUDACBIOTECHCOLTD-JP2017/160205,2017,ALocationinpatent:Paragraph0225;0226

[4]CurrentPatentAssignee:HANGZHOUDACBIOTECHCOLTD-US2017/296663,2017,A1Locationinpatent:Paragraph0200;0201

[5]CurrentPatentAssignee:HANGZHOUDACBIOTECHCOLTD-CN110279872,2019,ALocationinpatent:Paragraph0032;0305-0307

Literature

Title: Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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SDS
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Tags:57078-99-6 Molecular Formula|57078-99-6 MDL|57078-99-6 SMILES|57078-99-6 5-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)pentanoic acid