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571203-78-6,MFCD09837984
Catalog No.:AA003PUY

571203-78-6 | Erastin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
50mg
98%
in stock  
$179.00   $125.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PUY
Chemical Name:
Erastin
CAS Number:
571203-78-6
Molecular Formula:
C30H31ClN4O4
Molecular Weight:
547.0445
MDL Number:
MFCD09837984
SMILES:
CCOc1ccccc1n1c(nc2c(c1=O)cccc2)C(N1CCN(CC1)C(=O)COc1ccc(cc1)Cl)C
Properties
Properties
 
Form:
Solid  
MP:
173 - 177ºC  
Solubility:
DMSO: soluble5mg/mL, clear (warmed)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
871  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.8  

Literature

Title: RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death.

Journal: Oncotarget 20160927

Title: Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Journal: Cell 20120525

Title: Functional model of metabolite gating by human voltage-dependent anion channel 2.

Journal: Biochemistry 20110503

Title: Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.

Journal: Cancer cell 20030301

Title: Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72.

Title: Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79.

Title: Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.

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