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5719-85-7,MFCD00144466
Catalog No.:AA00E8SQ

5719-85-7 | 4-Hydroxytolbutamide

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Purity
Availability
Price(USD)
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1mg
≥98%
in stock  
$59.00   $41.00
- +
5mg
≥98%
in stock  
$219.00   $153.00
- +
10mg
≥98%
in stock  
$409.00   $286.00
- +
25mg
≥98%
in stock  
$948.00   $663.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8SQ
Chemical Name:
4-Hydroxytolbutamide
CAS Number:
5719-85-7
Molecular Formula:
C12H18N2O4S
Molecular Weight:
286.3473
MDL Number:
MFCD00144466
SMILES:
CCCCNC(=O)NS(=O)(=O)c1ccc(cc1)CO
Properties
Computed Properties
 
Complexity:
370  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
1.1  

Literature

Title: Validated assays for human cytochrome P450 activities.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601

Title: Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.

Journal: European journal of clinical pharmacology 20040501

Title: Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020601

Title: Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers.

Journal: Pharmacogenetics 20020301

Title: Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans.

Journal: Pharmacogenetics 20020301

Title: Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71.

Title: Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

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