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578-74-5,MFCD00016787
Catalog No.:AA003NUF

578-74-5 | Apigenin 7-Glucoside

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Purity
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1mg
99+%
in stock  
$22.00   $15.00
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5mg
99+%
in stock  
$48.00   $34.00
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10mg
99+%
in stock  
$73.00   $51.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003NUF
Chemical Name:
Apigenin 7-Glucoside
CAS Number:
578-74-5
Molecular Formula:
C21H20O10
Molecular Weight:
432.3775
MDL Number:
MFCD00016787
SMILES:
OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)c2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Properties
 
BP:
788.9°C at 760 mmHg  
Form:
Solid  
MP:
230-237 °C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
675  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
4  
XLogP3:
-0.1  

Literature

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Title: A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.

Journal: Bioorganic & medicinal chemistry letters 20120915

Title: LC determination of luteolin-7-O-β-D-glucoside and apigenin-7-O-β-D-glucoside in rat plasma after administration of Humulus scandens extract and its application to pharmacokinetic studies.

Journal: Natural product research 20120101

Title: Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ.

Journal: PloS one 20120101

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Journal: Journal of pharmaceutical and biomedical analysis 20111215

Title: Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands.

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Title: Hexaconazole induces antioxidant protection and apigenin-7-glucoside accumulation in Matricaria chamomilla plants subjected to drought stress.

Journal: Journal of plant physiology 20110515

Title: Apigetrin induces erythroid differentiation of human leukemia cells K562: proteomics approach.

Journal: Molecular nutrition & food research 20110501

Title: High-performance liquid chromatographic determination and pharmacokinetic study of apigenin-7-O-β-D-glucoside in rat plasma after intravenous administration.

Journal: Archives of pharmacal research 20110501

Title: Flavonoid composition of Juniperus oblonga Bieb.

Journal: Bulletin of experimental biology and medicine 20110401

Title: Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

Journal: Bioorganic & medicinal chemistry 20110315

Title: Phenolic compounds from Achillea millefolium L. and their bioactivity.

Journal: Acta biochimica Polonica 20110101

Title: Isolation of 3 flavonoids from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potentials by using the E. coli WP2 test system.

Journal: Journal of food science 20110101

Title: Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.

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Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

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Title: [Study on the flavonoids constituents of Trachelospermum jasminoides].

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Title: [Chemical constituents in Buddleja albiflora].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

Title: Antiestrogenic constituents of the Thai medicinal plants Capparis flavicans and Vitex glabrata.

Journal: Journal of natural products 20091101

Title: Mesophyll distribution of 'antioxidant' flavonoid glycosides in Ligustrum vulgare leaves under contrasting sunlight irradiance.

Journal: Annals of botany 20091001

Title: Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Triterpenoids and flavonoids from celery (Apium graveolens).

Journal: Journal of natural products 20090901

Title: [Studies on antibacterial constituents of Discocleidion rufescens (2)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601

Title: [Studies on chemical components of Lobelia chinensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

Title: A new acylated quercetin glycoside from the leaves of Stevia rebaudiana Bertoni.

Journal: Natural product research 20090101

Title: Simultaneous determination of nine major active compounds in Dracocephalum rupestre by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Chemical constituents from the seeds of Trifolium alexandrinum.

Journal: Natural product research 20081201

Title: [Flavones from flowers of Paulownia fortunei].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Solid-liquid transfer of biophenols from olive leaves for the enrichment of edible oils by a dynamic ultrasound-assisted approach.

Journal: Journal of agricultural and food chemistry 20080827

Title: [Studies on chemical constituents from Pteris multifida].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

Title: Antioxidative activity of the flower of Torenia fournieri.

Journal: Journal of natural medicines 20080401

Title: [Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301

Title: Chemical constituents from the leaves of Broussonetia papyrifera.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080201

Title: Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells.

Journal: Journal of agricultural and food chemistry 20071114

Title: Two new phenolic constituents of Humulus japonicus and their cytotoxicity test in vitro.

Journal: Archives of pharmacal research 20071101

Title: Achillea millefolium L. s.l. -- is the anti-inflammatory activity mediated by protease inhibition?

Journal: Journal of ethnopharmacology 20070905

Title: Constituents of Ocimum sanctum with antistress activity.

Journal: Journal of natural products 20070901

Title: [Studies on flavones in of Lavandula augustifolia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070501

Title: In vitro estrogenic activity of Achillea millefolium L.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20070201

Title: Superheated liquid extraction of oleuropein and related biophenols from olive leaves.

Journal: Journal of chromatography. A 20061215

Title: [Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents].

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Title: [Studies on chemical constituents of Acroptilon repens].

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Title: Development of an HPLC-PAD-MS assay for the identification and quantification of major phenolic edelweiss (Leontopodium alpium Cass.) constituents.

Journal: Phytochemical analysis : PCA 20060101

Title: Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051201

Title: Additional antiprotozoal constituents from Cuphea pinetorum, a plant used in Mayan traditional medicine to treat diarrhoea.

Journal: Phytotherapy research : PTR 20050801

Title: Mechanisms of apigenin-7-glucoside as a hepatoprotective agent.

Journal: Biomedical and environmental sciences : BES 20050201

Title: Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.

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Title: Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin.

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Title: Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice.

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Title: A novel cytotoxic C-methylated biflavone, taiwanhomoflavone-B from the twigs of Cephalotaxus wilsoniana.

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Title: Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model.

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Title: Phenolic glycosides from Phagnalon rupestre.

Journal: Phytochemistry 20020401

Title: Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils.

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Journal: Journal of natural products 19990601

Title: Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Journal: Journal of natural products 19940101

Title: Nasr Bouzaiene N et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Life Sci. 2016 Jan 1;144:80-5.

Title: Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation. 2015 Jun;89(5):146-55.

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