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58-05-9,MFCD00867488
Catalog No.:AA0039Y7

58-05-9 | Folinic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$56.00   $39.00
- +
250mg
95%
in stock  
$96.00   $67.00
- +
1g
95%
in stock  
$247.00   $173.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0039Y7
Chemical Name:
Folinic acid
CAS Number:
58-05-9
Molecular Formula:
C20H23N7O7
Molecular Weight:
473.4393
MDL Number:
MFCD00867488
SMILES:
O=CN1C(CNc2ccc(cc2)C(=O)N[C@H](C(=O)O)CCC(=O)O)CNc2c1c(=O)nc([nH]2)N
Properties
Computed Properties
 
Complexity:
911  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.2  

Literature

Title: Levoleucovorin as replacement for leucovorin in cancer treatment.

Journal: The Annals of pharmacotherapy 20121001

Title: Trafficking of intracellular folates.

Journal: Advances in nutrition (Bethesda, Md.) 20110701

Title: Is levoleucovorin an alternative to racemic leucovorin? A literature review.

Journal: Clinical colorectal cancer 20091001

Title: Intrathecal leucovorin after intrathecal methotrexate overdose.

Journal: Journal of pediatric hematology/oncology 19960801

Title: Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 19930101

Title: Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats.

Journal: Antimicrobial agents and chemotherapy 19860201

Title: Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

Journal: The Journal of biological chemistry 19850815

Title: Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.

Title: Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.

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SDS
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Tags:58-05-9 Molecular Formula|58-05-9 MDL|58-05-9 SMILES|58-05-9 Folinic acid
Catalog No.: AA0039Y7
58-05-9,MFCD00867488
58-05-9 | Folinic acid
Pack Size： 100mg
Purity： 95%
in stock
$56.00 $39.00
Pack Size： 250mg
Purity： 95%
in stock
$96.00 $67.00
Pack Size： 1g
Purity： 95%
in stock
$247.00 $173.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0039Y7
Chemical Name: Folinic acid
CAS Number: 58-05-9
Molecular Formula: C20H23N7O7
Molecular Weight: 473.4393
MDL Number: MFCD00867488
SMILES: O=CN1C(CNc2ccc(cc2)C(=O)N[C@H](C(=O)O)CCC(=O)O)CNc2c1c(=O)nc([nH]2)N
Properties
Complexity: 911  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 34  
Hydrogen Bond Acceptor Count: 10  
Hydrogen Bond Donor Count: 7  
Isotope Atom Count: 0  
Rotatable Bond Count: 9  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.2  
Literature fold

Title: Levoleucovorin as replacement for leucovorin in cancer treatment.

Journal: The Annals of pharmacotherapy20121001

Title: Trafficking of intracellular folates.

Journal: Advances in nutrition (Bethesda, Md.)20110701

Title: Is levoleucovorin an alternative to racemic leucovorin? A literature review.

Journal: Clinical colorectal cancer20091001

Title: Intrathecal leucovorin after intrathecal methotrexate overdose.

Journal: Journal of pediatric hematology/oncology19960801

Title: Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology19930101

Title: Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats.

Journal: Antimicrobial agents and chemotherapy19860201

Title: Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

Journal: The Journal of biological chemistry19850815

Title: Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.

Title: Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.

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