Home Amines 134-35-0
134-35-0,MFCD00900533
Catalog No.:AA007ZXN

134-35-0 | (2S)-2-(4-(((2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

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50mg
99%
in stock  
$149.00   $104.00
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250mg
98%
in stock  
$173.00   $121.00
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1g
98%
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$277.00   $194.00
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5g
98%
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$824.00   $577.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007ZXN
Chemical Name:
(2S)-2-(4-(((2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
CAS Number:
134-35-0
Molecular Formula:
C20H25CaN7O6
Molecular Weight:
499.5338
MDL Number:
MFCD00900533
SMILES:
OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NCC1CNc2c(N1C)c(=O)nc([nH]2)N.[Ca]
Properties
Computed Properties
 
Complexity:
865  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.5  

Downstream Synthesis Route
N-4-(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methylaminobenzoyl-L-glutamicacid 
 
C20H23N7O6 
  4271-30-1 

[1]PhotochemistryandPhotobiology,2006,vol.82,p.1651-1655

CASUnavailable 
  134-35-0   
CASUnavailable 

[1]CurrentPatentAssignee:Zhu,Hong-EP1952825,2008,A1Locationinpatent:Page/Pagecolumn10

[1]CurrentPatentAssignee:SOCIETECIVILENOUVELLEMARCELLESAFFRE-WO2009/103333,2009,A1Locationinpatent:Page/Pagecolumn8-9

[1]CurrentPatentAssignee:SOCIETECIVILENOUVELLEMARCELLESAFFRE-WO2009/103333,2009,A1Locationinpatent:Page/Pagecolumn9-10

Literature

Title: Circulating unmetabolized folic Acid: relationship to folate status and effect of supplementation.

Journal: Obstetrics and gynecology international 20120101

Title: Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits.

Journal: Neuropediatrics 20071201

Title: Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation.

Journal: Biochemistry 20070612

Title: Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.

Journal: Molecular genetics and metabolism 20070501

Title: The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

Title: Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects.

Journal: The American journal of clinical nutrition 20070401

Title: 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.

Journal: The Journal of biological chemistry 20070209

Title: Absorption of folate by Caco-2 cells is not affected by high glucose concentration.

Journal: European journal of pharmacology 20061203

Title: Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase.

Journal: The Journal of biological chemistry 20060707

Title: The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation.

Journal: The British journal of nutrition 20060701

Title: Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization.

Journal: American journal of physiology. Renal physiology 20040301

Title: A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity.

Journal: Molecular genetics and metabolism 19980701

Title: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase.

Journal: Nature genetics 19950501

Title: Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.

Journal: Neurology 19920401

Title: Wright AJ, et al. Comparison of (6 S)-5-methyltetrahydrofolic acid v. folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults. Br J Nutr. 2010 Mar;103(5):724-9.

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SDS
Tags:134-35-0 Molecular Formula|134-35-0 MDL|134-35-0 SMILES|134-35-0 (2S)-2-(4-(((2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid