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135-16-0,MFCD00135583
Catalog No.:AA009BHB

135-16-0 | Tetrahydrofolic acid

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Purity
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Price(USD)
Quantity
  
5mg
98% by HPLC
in stock  
$103.00   $72.00
- +
10mg
98% by HPLC
in stock  
$129.00   $90.00
- +
100mg
67%
in stock  
$151.00   $106.00
- +
250mg
67%
in stock  
$354.00   $248.00
- +
1g
67%
in stock  
$798.00   $559.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009BHB
Chemical Name:
Tetrahydrofolic acid
CAS Number:
135-16-0
Molecular Formula:
C19H23N7O6
Molecular Weight:
445.4292
MDL Number:
MFCD00135583
SMILES:
OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NCC1CNc2c(N1)c(=O)[nH]c(n2)N
Properties
Computed Properties
 
Complexity:
834  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.6  

Literature

Title: Tetrahydrofolate recognition by the mitochondrial folate transporter.

Journal: The Journal of biological chemistry 20110909

Title: Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.

Journal: Chemico-biological interactions 20110530

Title: A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users.

Journal: The American journal of clinical nutrition 20070401

Title: Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.

Journal: Journal of cellular biochemistry 20060901

Title: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.

Journal: Endocrine-related cancer 20060601

Title: Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization.

Journal: American journal of physiology. Renal physiology 20040301

Title: Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase.

Journal: The Journal of biological chemistry 20020809

Title: Molecular cloning of the human placental folate transporter.

Journal: Biochemical and biophysical research communications 19950117

Title: Thymidylate synthetase activity in the Novikoff hepatoma.

Journal: Cancer research 19761201

Title: The toxicity of tetrahydrohomofolic acid in normal and malaria-infected monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 19680201

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Tags:135-16-0 Molecular Formula|135-16-0 MDL|135-16-0 SMILES|135-16-0 Tetrahydrofolic acid