Title: Final results of a prematurely discontinued Phase 1/2 study of eniluracil with escalating doses of 5-fluorouracil administered orally in patients with advanced hepatocellular carcinoma.
Journal: Cancer chemotherapy and pharmacology 20111001
Title: Determination of eniluracil and 5-fluorouracil in human plasma by LC-MS/MS.
Journal: Bioanalysis 20101201
Title: A semi-automated non-radioactive system for measuring recovery of RNA synthesis and unscheduled DNA synthesis using ethynyluracil derivatives.
Journal: DNA repair 20100504
Title: A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil.
Journal: Clinical colorectal cancer 20100101
Title: The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer.
Journal: Best practice & research. Clinical gastroenterology 20070101
Title: A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract.
Journal: Cancer investigation 20060201
Title: A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.
Journal: International journal of radiation oncology, biology, physics 20040301
Title: Treatment of colorectal cancer metastasis: the role of chemotherapy.
Journal: Cancer metastasis reviews 20040101
Title: Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer.
Journal: Cancer chemotherapy and pharmacology 20031101
Title: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889.
Journal: International journal of cancer 20030920
Title: Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule.
Journal: Cancer chemotherapy and pharmacology 20030701
Title: A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030601
Title: Practical considerations in the use of oral fluoropyrimidines.
Journal: Seminars in oncology 20030601
Title: Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
Journal: Bioorganic & medicinal chemistry letters 20030310
Title: Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism.
Journal: Journal of surgical oncology 20030201
Title: A study to evaluate the pharmacokinetics of oral 5-fluorouracil and eniluracil after concurrent administration to patients with refractory solid tumours and varying degrees of renal impairment (FUMA1005).
Journal: Cancer chemotherapy and pharmacology 20030101
Title: Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.
Journal: Journal of the National Cancer Institute 20021218
Title: Phase I study of eniluracil, oral 5-fluororacil and gemcitabine in patients with advanced malignancy.
Journal: Investigational new drugs 20021101
Title: Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer.
Journal: Investigational new drugs 20021101
Title: Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20021001
Title: Eniluracil's need for a targeted approach: a lesson in drug development.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020901
Title: Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil.
Journal: Cancer chemotherapy and pharmacology 20020501
Title: Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine dehydrogenase inhibition.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501
Title: Phase I study of eniluracil and oral 5-fluorouracil in combination with docetaxel in the treatment of patients with metastatic breast carcinoma.
Journal: Cancer 20020501
Title: Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer.
Journal: Clinical colorectal cancer 20020501
Title: Inhibiting 5-fluorouracil breakdown: a broken down approach to 5-fluorouracil modulation.
Journal: Clinical colorectal cancer 20020501
Title: Can eniluracil improve 5-fluorouracil therapy?
Journal: Clinical colorectal cancer 20020501
Title: Oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20020401
Title: Randomized, open-label, phase III study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic/advanced colorectal cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315
Title: Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315
Title: An evolving role for oral fluoropyrimidine drugs.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020215
Title: Multicenter phase II study of a 28-day regimen of orally administered eniluracil and fluorouracil in the treatment of patients with anthracycline- and taxane-resistant advanced breast cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020215
Title: A phase I trial of weekly paclitaxel plus prolonged oral eniluracil/5-fluorouracil in patients with refractory malignancies.
Journal: The oncologist 20020101
Title: New drugs and combinations in the palliative treatment of colon and rectal cancer.
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20010901
Title: A phase II study of oral eniluracil/fluorouracil in patients with anthracycline-refractory or anthracycline- and taxane-refractory advanced breast cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010901
Title: Crystal structure prediction for eniluracil.
Journal: Journal of pharmaceutical sciences 20010801
Title: New options for outpatient chemotherapy--the role of oral fluoropyrimidines.
Journal: Cancer treatment reviews 20010801
Title: Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer.
Journal: Cancer research 20010701
Title: A phase II trial of oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma.
Journal: European journal of cancer (Oxford, England : 1990) 20010701
Title: Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil.
Journal: Anti-cancer drugs 20010701
Title: A National Cancer Institute of Canada clinical trials group phase II study of eniluracil (776C85) and oral 5-fluorouracil in patients with advanced squamous cell head and neck cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010701
Title: Advances in the treatment of metastatic colorectal cancer.
Journal: Clinical colorectal cancer 20010501
Title: Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma.
Journal: Cancer 20010401
Title: Oral eniluracil/5-FU for advanced colon and breast carcinomas.
Journal: Oncology (Williston Park, N.Y.) 20010101
Title: Oral fluoropyrimidines: are they the equivalent of parenteral infusional 5-fluorouracil?
Journal: Cancer investigation 20010101
Title: The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status.
Journal: The oncologist 19990101
Title: 5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs.
Journal: Biochemical pharmacology 19940719
Title: Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.