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622864-54-4,MFCD09753286
Catalog No.:AA00EF0V

622864-54-4 | PD407824

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1mg
≥98%
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$70.00   $49.00
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5mg
≥98%
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$193.00   $135.00
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10mg
≥98%
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$350.00   $245.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EF0V
Chemical Name:
PD407824
CAS Number:
622864-54-4
Molecular Formula:
C20H12N2O3
Molecular Weight:
328.3209
MDL Number:
MFCD09753286
SMILES:
Oc1ccc2c(c1)c1c([nH]2)cc(c2c1c(=O)[nH]c2=O)c1ccccc1
Properties
Computed Properties
 
Complexity:
573  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
3.5  

Literature

Title: Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131001

Title: Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors.

Journal: European journal of medicinal chemistry 20090401

Title: Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.

Journal: Journal of translational medicine 20090101

Title: Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.

Journal: European journal of medicinal chemistry 20080601

Title: 3D-QSAR studies of Checkpoint Kinase Weel inhibitors based on molecular docking, CoMFA and CoMSIA.

Journal: European journal of medicinal chemistry 20080501

Title: 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.

Journal: Journal of medicinal chemistry 20060810

Title: Palmer BD, et al. 4-Phenylpyrrolo,4-ccarbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem. 2006 Aug 10;49(16):4896-911.

Title: Feng L, et al. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Rep. 2016 May 31;15(9):2063-75.

Title: Smaill JB, et al. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo,4-ccarbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpointkinases. Eur J Med Chem. 2008 Jun;43(6):1276-96. Epub 2007 Aug 6.

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