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623142-96-1,MFCD12024693
Catalog No.:AA00E9MQ

623142-96-1 | Ki20227

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$48.00   $33.00
- +
5mg
≥98%
in stock  
$176.00   $123.00
- +
10mg
98%
in stock  
$266.00   $186.00
- +
25mg
98%
in stock  
$451.00   $316.00
- +
500mg
98% by HPLC
in stock  
$6,554.00   $4,588.00
- +
1000mg
98% by HPLC
in stock  
$10,449.00   $7,314.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00E9MQ
Chemical Name:
Ki20227
CAS Number:
623142-96-1
Molecular Formula:
C24H24N4O5S
Molecular Weight:
480.5362
MDL Number:
MFCD12024693
SMILES:
COc1cc(ccc1NC(=O)NC(c1nccs1)C)Oc1ccnc2c1cc(OC)c(c2)OC
Properties
Computed Properties
 
Complexity:
661  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.6  

Downstream Synthesis Route
32315-10-9    432047-36-4   
Ki20227 

[1]Patent:EP1535910,2005,A1.Locationinpatent:Page/Pagecolumn42

[1]CurrentPatentAssignee:KIRINHOLDINGSCOLTD;KyowaKirin(in:KirinHoldings)-EP1535910,2005,A1

[1]CurrentPatentAssignee:KIRINHOLDINGSCOLTD;KyowaKirin(in:KirinHoldings)-EP1535910,2005,A1

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Inhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells.

Journal: Breast cancer research and treatment 20110901

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20080301

Title: The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.

Journal: European journal of immunology 20080101

Title: A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

Journal: Molecular cancer therapeutics 20061101

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SDS
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