Name: Name:4-Chloro-6,7-difluoroquinazoline
Brand: AABLOCKS
SKU: AA00ECU0
Rating: 90 (10 reviews)

Catalog No.: AA00ECU0

625080-60-6 | 4-Chloro-6,7-difluoroquinazoline

Pack Size： 250mg

Purity： 95%

in stock

$34.00 $24.00

Pack Size： 1g

Purity： 95%

in stock

$93.00 $65.00

Pack Size： 5g

Purity： 95%

in stock

$463.00 $324.00

Pack Size： 10g

Purity： 95%

in stock

$891.00 $624.00

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Technical Information

Catalog Number: AA00ECU0

Chemical Name: 4-Chloro-6,7-difluoroquinazoline

CAS Number: 625080-60-6

Molecular Formula: C8H3ClF2N2

Molecular Weight: 200.5726

MDL Number: MFCD06657230

SMILES: Fc1cc2c(cc1F)ncnc2Cl

Properties

Form: Solid

Storage: Inert atmosphere;2-8℃;

Complexity: 193

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 13

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 0

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 2.7

Upstream Synthesis Route

205259-37-6

625080-60-6

[1]Patent:WO2009/117080,2009,A1,.Locationinpatent:Page/Pagecolumn165

[2]Patent:US2006/281772,2006,A1,.Locationinpatent:Page/Pagecolumn131

205259-37-6

625080-60-6

[1]BioorganicandMedicinalChemistryLetters,2001,vol.11,#4,p.545-548

[2]BioorganicandMedicinalChemistry,2003,vol.11,#4,p.609-616

[3]Patent:WO2006/71958,2006,A1,.Locationinpatent:Page/Pagecolumn133

[4]Patent:CN107200715,2017,A,.Locationinpatent:Paragraph0075;0076;0077

211374-80-0

625080-60-6

[1]BioorganicandMedicinalChemistry,2003,vol.11,#4,p.609-616

[2]BioorganicandMedicinalChemistryLetters,2001,vol.11,#4,p.545-548

83506-93-8

625080-60-6

[1]Patent:CN107200715,2017,A,

[2]Patent:WO2009/117080,2009,A1,

Downstream Synthesis Route

17413-10-4

625080-60-6

(6,7-difluoro-quinazolin-4-yl)-(2,3-dihydro-benzo1,4dioxin-6-ylmethyl)-amine

[1]BioorganicandMedicinalChemistry,2003,vol.11,p.609-616

27757-86-4

625080-60-6

(6,7-difluoro-quinazolin-4-yl)-thiophen-3-ylmethyl-amine

[1]BioorganicandMedicinalChemistry,2003,vol.11,p.609-616

54060-30-9

625080-60-6

N-(3-ethynylphenyl)-6,7-difluoroquinazolin-4-amine

[1]CurrentPatentAssignee:SUZHOUFUSHILAIPHARMACEUTICAL-CN111763214,2020,ALocationinpatent:Paragraph0068;0075;0076

[2]CurrentPatentAssignee:SHAANXINORMALUNIVERSITY-CN107200715,2017,ALocationinpatent:Paragraph0084;0085;0086

[3]Zhang,Yaling;Hou,Qiaoli;Li,Xiabing;Zhu,Jiuling;Wang,Wei;Li,Baolin;Zhao,Lijun;Xia,Haibin[EuropeanJournalofMedicinalChemistry,2019,vol.178,p.417-432]

[4]Asquith,ChristopherR.M.;Bennett,JamesM.;Elkins,JonathanM.;Laitinen,Tuomo;Poso,Antti;Tizzard,GrahamJ.;Wells,CarrowI.;Zuercher,WilliamJ.[ChemMedChem,2019]

875798-81-5

625080-60-6

C18H19F2N5O2S

[1]BioorganicChemistry,2020,vol.98