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Home Other Building Blocks 627908-92-3
627908-92-3,MFCD16495822
Catalog No.:AA00ECBZ

627908-92-3 | SU14813

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$24.00   $17.00
- +
5mg
98+%
in stock  
$57.00   $40.00
- +
10mg
98+%
in stock  
$85.00   $60.00
- +
50mg
98+%
in stock  
$241.00   $169.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ECBZ
Chemical Name:
SU14813
CAS Number:
627908-92-3
Molecular Formula:
C23H27FN4O4
Molecular Weight:
442.4833
MDL Number:
MFCD16495822
SMILES:
OC(CN1CCOCC1)CNC(=O)c1c(C)[nH]c(c1C)/C=C/1\C(=O)Nc2c1cc(F)cc2
Properties
Computed Properties
 
Complexity:
729  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.9  

Literature

Title: Phase I trial of SU14813 in patients with advanced solid malignancies.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110101

Title: Evaluation of CXCR4 inhibition in the prevention and intervention model of laser-induced choroidal neovascularization.

Journal: Investigative ophthalmology & visual science 20100701

Title: Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.

Journal: Blood 20070915

Title: SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity.

Journal: Molecular cancer therapeutics 20060701

Title: Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5(7):1774-82.

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SDS
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