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63-75-2,MFCD00059167
Catalog No.:AA00EK3V

63-75-2 | Arecoline

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5mg
98%
1 week  
$256.00   $179.00
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25mg
98%
1 week  
$524.00   $367.00
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100mg
98%
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$1,292.00   $904.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EK3V
Chemical Name:
Arecoline
CAS Number:
63-75-2
Molecular Formula:
C8H13NO2
Molecular Weight:
155.1943
MDL Number:
MFCD00059167
SMILES:
COC(=O)C1=CCCN(C1)C
NSC Number:
56321
Properties
Properties
 
BP:
209°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
187  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
0.3  

Literature

Title: Taiwanin C selectively inhibits arecoline and 4-NQO-induced oral cancer cell proliferation via ERK1/2 inactivation.

Journal: Environmental toxicology 20170101

Title: Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice.

Journal: Environmental toxicology 20161201

Title: Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase.

Journal: Toxicology 20160217

Title: Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress.

Journal: The Journal of toxicological sciences 20140801

Title: Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20131001

Title: Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.

Journal: Oral diseases 20121001

Title: Characterization of protein adducts formed by toxic alkaloids by nano-scale liquid chromatography with mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20121001

Title: Arecoline induced cell cycle arrest, apoptosis, and cytotoxicity to human endothelial cells.

Journal: Clinical oral investigations 20120801

Title: Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and activating K(ATP) channels.

Journal: Acta pharmacologica Sinica 20120801

Title: Monoamine oxidase A variants are associated with heavy betel quid use.

Journal: Addiction biology 20120701

Title: Simultaneous determination of synephrine, arecoline, and norisoboldine in Chinese patent medicine Si-Mo-Tang oral liquid preparation by strong cation exchange high performance liquid chromatography.

Journal: Pharmaceutical biology 20120701

Title: Arecoline-induced death of human leukemia K562 cells is associated with surface up-modulation of TNFR2.

Journal: Journal of cellular physiology 20120501

Title: Potential action of betel alkaloids on positive and negative symptoms of schizophrenia: a review.

Journal: Nordic journal of psychiatry 20120401

Title: Alkaloids from areca (betel) nuts and their effects on human sperm motility in vitro.

Journal: Journal of food science 20120401

Title: β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20120401

Title: Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells.

Journal: Toxicology and applied pharmacology 20120115

Title: FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.

Journal: PloS one 20120101

Title: Pathogenesis of oral submucous fibrosis.

Journal: Journal of cancer research and therapeutics 20120101

Title: Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes.

Journal: Cell biology and toxicology 20111201

Title: Areca nut induces miR-23a and inhibits repair of DNA double-strand breaks by targeting FANCG.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111001

Title: Effect of cholinergic drugs on the activity of basic carboxypeptidases in rat nervous tissue.

Journal: Biochemistry. Biokhimiia 20111001

Title: Arecoline augments cellular proliferation in the prostate gland of male Wistar rats.

Journal: Toxicology and applied pharmacology 20110901

Title: Hemeoxygenase-1 expression in response to arecoline-induced oxidative stress in human umbilical vein endothelial cells.

Journal: International journal of cardiology 20110901

Title: Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20110501

Title: Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110501

Title: Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction.

Journal: Oral oncology 20110501

Title: [Determination of synephrine and arecoline contents in Xiao'er Xiaoji Zhike oral liquid].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

Title: Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesis.

Journal: Journal of agricultural and food chemistry 20110413

Title: Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.

Journal: Biochimica et biophysica acta 20110401

Title: Arecoline stimulated Cyr61 production in human gingival epithelial cells: inhibition by lovastatin.

Journal: Oral oncology 20110401

Title: Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110215

Title: Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Journal: The Journal of pathology 20110201

Title: Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.

Journal: Nutritional neuroscience 20110101

Title: Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system.

Journal: Free radical biology & medicine 20101130

Title: Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA(2)β (VIA)-deficient mice.

Journal: Journal of lipid research 20101101

Title: High-throughput simultaneous analysis of five urinary metabolites of areca nut and tobacco alkaloids by isotope-dilution liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101001

Title: Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.

Journal: Oral diseases 20101001

Title: Effects of arecoline on adipogenesis, lipolysis, and glucose uptake of adipocytes-A possible role of betel-quid chewing in metabolic syndrome.

Journal: Toxicology and applied pharmacology 20100615

Title: Xenobiotic metabolism: a view through the metabolometer.

Journal: Chemical research in toxicology 20100517

Title: Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice.

Journal: Molecular and cellular endocrinology 20100505

Title: Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: implication for carcinogenesis.

Journal: Oral oncology 20100401

Title: Arecoline excites the contraction of distal colonic smooth muscle strips in rats via the M3 receptor-extracellular Ca2+ influx - Ca2+ store release pathway.

Journal: Canadian journal of physiology and pharmacology 20100401

Title: [Effects of arecoline on contractile activity of isolated antral circular muscle strips in guinea pigs].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100201

Title: Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.

Journal: Chemico-biological interactions 20100105

Title: Systemic administration of arecoline reduces ethanol-induced sleeping through activation of central muscarinic receptor in mice.

Journal: Alcoholism, clinical and experimental research 20100101

Title: Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation.

Journal: Molecular cancer 20100101

Title: Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells.

Journal: BMC cell biology 20100101

Title: Quantification of blood betel quid alkaloids and urinary 8-hydroxydeoxyguanosine in humans and their association with betel chewing habits.

Journal: Journal of analytical toxicology 20100101

Title: Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors.

Journal: Journal of periodontal research 20091201

Title: Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models.

Journal: European journal of medicinal chemistry 20091201

Title: Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes.

Journal: Journal of periodontal research 20091001

Title: Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin.

Journal: Oral oncology 20090901

Title: Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models.

Journal: Bioorganic & medicinal chemistry 20090801

Title: Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.

Journal: Journal of cellular biochemistry 20090601

Title: Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.

Journal: Cancer research 20090315

Title: Investigation of the regulation of transcriptional changes in Ancylostoma caninum larvae following serum activation, with a focus on the insulin-like signalling pathway.

Journal: Veterinary parasitology 20090205

Title: Transglutaminase-2 regulation by arecoline in gingival fibroblasts.

Journal: Journal of dental research 20090201

Title: (4S,5R,6R)-para-mentha-1,8-dien-5,6-diol is a new highly effective anticonvulsant agent.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

Title: The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.

Journal: Oral oncology 20080901

Title: Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats.

Journal: Neuroscience letters 20080822

Title: Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: role of mucosal muscarinic receptors.

Journal: American journal of physiology. Renal physiology 20080801

Title: Effects of arecoline on testosterone release in rats.

Journal: American journal of physiology. Endocrinology and metabolism 20080801

Title: Muscarinic receptor 1 agonist activity of novel N-arylthioureas substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models.

Journal: Bioorganic & medicinal chemistry 20080801

Title: Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats.

Journal: International journal of experimental pathology 20080801

Title: [The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080701

Title: Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models.

Journal: Bioorganic & medicinal chemistry 20080501

Title: Involvement of ionotropic glutamate receptors in the appearance of arecoline tremor in mice.

Journal: Neuroscience and behavioral physiology 20080501

Title: The upregulation of heat shock protein 47 expression in human buccal fibroblasts stimulated with arecoline.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20080401

Title: Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.

Journal: Bioorganic & medicinal chemistry 20080315

Title: Role of the cholinergic mechanisms of the ventrolateral preoptic area of the hypothalamus in regulating the state of sleep and waking in pigeons.

Journal: Neuroscience and behavioral physiology 20080301

Title: The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas.

Journal: Oral oncology 20080201

Title: Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models.

Journal: Neurochemistry international 20080201

Title: Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes.

Journal: Toxicology 20080114

Title: [Effect of arecholine and atropine administration on the carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activities in the rat nervous tissue].

Journal: Biomeditsinskaia khimiia 20080101

Title: Periodontal health status in pan chewers with or without the use of tobacco.

Journal: Oral health & preventive dentistry 20080101

Title: A 24-h access I.V. self-administration schedule of morphine reinforcement and the estimation of recidivism: Pharmacological modification by arecoline.

Journal: Neuroscience 20071109

Title: Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats.

Journal: Neurochemical research 20071101

Title: Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071101

Title: Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells.

Journal: Journal of hazardous materials 20071001

Title: Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system.

Journal: BJU international 20070901

Title: The effects of serotoninergic, noradrenergic, cholinergic and dopaminergic drugs on vigilance states in MPTP-treated mice.

Journal: Brain research 20070803

Title: Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells.

Journal: Journal of hazardous materials 20070719

Title: Ultrastructural and hormonal changes in the pineal-testicular axis following arecoline administration in rats.

Journal: Journal of experimental zoology. Part A, Ecological genetics and physiology 20070401

Title: Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigations.

Journal: Neuroscience and behavioral physiology 20070301

Title: Increased plasminogen activator inhibitor-1/tissue type plasminogen activator ratio in oral submucous fibrosis.

Journal: Oral diseases 20070301

Title: [Involvement of ionotropic glutamate receptors in the genesis of arecoline-induced tremor].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20070301

Title: The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases.

Journal: Biochemical pharmacology 20070215

Title: Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes.

Journal: Journal of periodontal research 20070201

Title: [Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes].

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20070101

Title: Effects of AIT-082, a purine derivative, on tremor induced by arecoline or oxotremorine in mice.

Journal: Pharmacology 20070101

Title: Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors.

Journal: The open medicinal chemistry journal 20070101

Title: Immune responses in mice to arecoline mediated by lymphocyte muscarinic acetylcholine receptor.

Journal: Cell biology international 20061201

Title: Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice.

Journal: Toxicology 20061003

Title: Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependence.

Journal: Psychopharmacology 20061001

Title: Genetic damage in cultured human keratinocytes stressed by long-term exposure to areca nut extracts.

Journal: Mutation research 20060725

Title: Oral submucous fibrosis: review on aetiology and pathogenesis.

Journal: Oral oncology 20060701

Title: Muscarinic stimulation of the mouse isolated whole bladder: physiological responses in young and ageing mice.

Journal: Autonomic & autacoid pharmacology 20060701

Title: [Synergic effects of synthesis arecoline in combination with snail-killing drugs niclosamide].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20060701

Title: A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse.

Journal: Chemical research in toxicology 20060601

Title: Comparative permeability of fresh and frozen/thawed porcine buccal mucosa towards various chemical markers.

Journal: SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 20060601

Title: Mapping out starvation responses.

Journal: Cell metabolism 20060401

Title: Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx.

Journal: Cell metabolism 20060401

Title: Prolonged exposure to arecoline arrested human KB epithelial cell growth: regulatory mechanisms of cell cycle and apoptosis.

Journal: Toxicology 20060315

Title: Characterization of nicotine's ability to serve as a negative feature in a Pavlovian appetitive conditioning task in rats.

Journal: Psychopharmacology 20060301

Title: Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse.

Journal: Journal of neurochemistry 20060201

Title: Bladder volume alters cholinergic responses of the isolated whole mouse bladder.

Journal: The Journal of urology 20060201

Title: Arecoline inhibits catecholamine release from perfused rat adrenal gland.

Journal: Acta pharmacologica Sinica 20060101

Title: Comparison study of autonomous activity in bladders from normal and paraplegic rats.

Journal: Neurourology and urodynamics 20060101

Title: Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa.

Journal: International journal of pharmaceutics 20051123

Title: Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the 'Meconium Project'.

Journal: Forensic science international 20051004

Title: Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils.

Journal: Journal of periodontology 20050301

Title: A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans.

Journal: The Journal of biological chemistry 20050225

Title: Determination of arecoline (areca nut alkaloid) and nicotine in hair by high-performance liquid chromatography/electrospray quadrupole mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation.

Journal: The Journal of biological chemistry 20041203

Title: Volume-induced effects on the isolated bladder: a possible local reflex.

Journal: BJU international 20041201

Title: Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.

Journal: Oral diseases 20041101

Title: Cholinergic regulation of the evoked quantal release at frog neuromuscular junction.

Journal: The Journal of physiology 20041001

Title: Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20041001

Title: Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits.

Journal: The Chinese journal of physiology 20040630

Title: Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa.

Journal: Archives of oral biology 20040501

Title: Proteasome inhibitors; synthesis and activity of arecoline oxide tripeptide derivatives.

Journal: Bioorganic & medicinal chemistry letters 20040419

Title: High-performance liquid chromatographic determination of arecoline in human saliva.

Journal: Journal of chromatography. A 20040402

Title: Arecoline tripeptide inhibitors of proteasome.

Journal: Journal of medicinal chemistry 20040311

Title: Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron.

Journal: Pain 20040101

Title: Developmental toxicity of arecoline, the major alkaloid in betel nuts, in zebrafish embryos.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20040101

Title: Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence.

Journal: Neurotoxicology and teratology 20040101

Title: Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.

Journal: BMC neuroscience 20040101

Title: Effects of aqueous extracts of 'Betel quid' and its constituents on testosterone production by dispersed mouse interstitial cells.

Journal: The American journal of Chinese medicine 20040101

Title: Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis.

Journal: Oral oncology 20031001

Title: Comparative in vitro permeability of human vaginal, small intestinal and colonic mucosa.

Journal: International journal of pharmaceutics 20030811

Title: Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline.

Journal: Carcinogenesis 20030801

Title: The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.

Journal: Oral oncology 20030601

Title: Attentional effects of nicotinic agonists in rats.

Journal: Neuropharmacology 20030601

Title: Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats.

Journal: Journal of neurochemistry 20030601

Title: C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.

Journal: Journal of medicinal chemistry 20030522

Title: Agonist- and nerve-induced phasic activity in the isolated whole bladder of the guinea pig: evidence for two types of bladder activity.

Journal: Experimental physiology 20030501

Title: The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20030301

Title: Autonomous activity in the isolated guinea pig bladder.

Journal: Experimental physiology 20030101

Title: Quantification of arecoline (areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography/electrospray quadrupole mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Synthesis of the ABC ring system of manzamine A.

Journal: The Journal of organic chemistry 20020823

Title: Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis.

Journal: Oral oncology 20020701

Title: Combined use of tertiary amine parasympathomimetics with a quaternary amine parasympatholitic--a new perspective to use parasympathomimetic drugs for systemic analgesia.

Journal: Die Pharmazie 20020701

Title: The environmental pollutant hexachlorobenzene causes eosinophilic and granulomatous inflammation and in vitro airways hyperreactivity in the Brown Norway rat.

Journal: Archives of toxicology 20020501

Title: [Perspectives on the treatment of organic mental disorders by the use of nootropic agents].

Journal: Voenno-meditsinskii zhurnal 20020501

Title: [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Mechanism of vascular relaxation by cholinomimetic drugs with special reference to pilocarpine and arecoline.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020201

Title: Chemical and analytical aspects of areca nut.

Journal: Addiction biology 20020101

Title: Neurological aspects of areca and betel chewing.

Journal: Addiction biology 20020101

Title: Effects of arecoline on calcium channel currents and caffeine-induced calcium release in isolated single ventricular myocyte of guinea pig.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

Title: Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating.

Journal: Cell 20011214

Title: Changes in the performance of schedule-induced polydipsia (SIP) in rats after arecoline and amphetamine treatments.

Journal: Proceedings of the National Science Council, Republic of China. Part B, Life sciences 20011001

Title: Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential.

Journal: Carcinogenesis 20010901

Title: Synergistic effects of nicotine on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20010901

Title: Muscarinic M2 receptors inhibit heat-induced CGRP release from isolated rat skin.

Journal: Neuroreport 20010808

Title: A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons.

Journal: Journal of neurophysiology 20010501

Title: Effects of methyl mercury, mercuric sulfide and cinnabar on active avoidance responses, Na+/K+-ATPase activities and tissue mercury contents in rats.

Journal: Proceedings of the National Science Council, Republic of China. Part B, Life sciences 20010401

Title: The effects of arecoline on the release of cytokines using cultured peripheral blood mononuclear cells from patients with oral mucous diseases.

Journal: The Kaohsiung journal of medical sciences 20010401

Title: Adverse effects of arecoline and nicotine on human periodontal ligament fibroblasts in vitro.

Journal: Journal of clinical periodontology 20010301

Title: Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro.

Journal: Clinical oral investigations 20010301

Title: Cancer induction in the DMBA hamster cheek pouch: a modified technique using a promoter.

Journal: The Laryngoscope 20010201

Title: Effects of Betel chewing on the central and autonomic nervous systems.

Journal: Journal of biomedical science 20010101

Title: M1 receptor activation is a requirement for arecoline analgesia.

Journal: Farmaco (Societa chimica italiana : 1989) 20010101

Title: Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor.

Journal: The Chinese journal of physiology 20000331

Title: Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle.

Journal: Life sciences 19990101

Title: Anti-nicotinic properties of anticholinergic antiparkinson drugs.

Journal: The Journal of pharmacy and pharmacology 19981101

Title: 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.

Journal: Journal of medicinal chemistry 19980604

Title: Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.

Journal: Molecular pharmacology 19970701

Title: Anticholinergic activity in mice and receptor-binding properties in rats of a series of synthetic tropane derivatives.

Journal: The Journal of pharmacy and pharmacology 19970301

Title: Pharmacological activity and receptor-binding characteristics of 2 beta-(2'-phenyl-2'-cyclopentyl-2'-hydroxy-ethoxy)tropane and its optical isomers.

Journal: Archives internationales de pharmacodynamie et de therapie 19960101

Title: Intrathecal cholinergic agonists lessen bupivacaine spinal-block-induced hypotension in rats.

Journal: Anesthesia and analgesia 19940701

Title: [The selectivity of the action of muscarinic agonists in vivo].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 19940101

Title: [The selectivity and protective properties of m-cholinolytics in dichlorodivinylphosphate poisoning].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 19920101

Title: [The possible role of presynaptic effects in realizing the protective action of M-cholinolytics in dimethyl dichlorovinyl phosphate poisoning].

Journal: Farmakologiia i toksikologiia 19910101

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Nicotine-induced tail-tremor and drug effects.

Journal: Pharmacology, biochemistry, and behavior 19891201

Title: Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats.

Journal: Japanese journal of pharmacology 19890501

Title: Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.

Journal: The Journal of pharmacology and experimental therapeutics 19890201

Title: Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.

Journal: Japanese journal of pharmacology 19881201

Title: Alleviation of scopolamine amnesia by different retrieval enhancing treatments.

Journal: Pharmacology, biochemistry, and behavior 19880801

Title: Effects of nootropic drugs in a scopolamine-induced amnesia model in mice.

Journal: Psychopharmacology 19880101

Title: Attenuation of scopolamine-induced amnesia in mice.

Journal: Psychopharmacology 19880101

Title: [Nonuniform expression of the dopamine-positive effect in different central m-cholinergic blockaders].

Journal: Farmakologiia i toksikologiia 19880101

Title: Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid.

Journal: Experimental neurology 19871201

Title: Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19851201

Title: Ethanol withdrawal tremor does not interact with physostigmine-induced tremor in rat.

Journal: Pharmacology, biochemistry, and behavior 19850901

Title: Screening for new compounds with antiherpes activity.

Journal: Antiviral research 19841001

Title: Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys.

Journal: Psychopharmacology 19840101

Title: The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.

Journal: Toxicology and applied pharmacology 19830401

Title: Neuropharmacology of the parasitic trematode, Schistosoma mansoni.

Journal: The American journal of tropical medicine and hygiene 19830101

Title: [Modification, by lithium, of catalepsy induced by central cholinergic stimulants and morphine-like drugs].

Journal: Comptes rendus des seances de la Societe de biologie et de ses filiales 19810101

Title: Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.

Journal: The British journal of psychiatry : the journal of mental science 19810101

Title: Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.

Journal: British journal of pharmacology 19800101

Title: Modification of cholinergic tremor by apomorphine and L-dopa in rats.

Journal: Acta physiologica Polonica 19800101

Title: Evidence that a nigral gabaergic--cholinergic balance controls posture.

Journal: European journal of pharmacology 19790101

Title: Effect of muscarinic cholinergic drugs on morphine-induced catalepsy, antinociception and changes in brain dopamine metabolism.

Journal: Psychopharmacology 19770323

Title: [Proceedings: On the central action of nomifensine (author's transl)].

Journal: Arzneimittel-Forschung 19760101

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Tags:63-75-2 Molecular Formula|63-75-2 MDL|63-75-2 SMILES|63-75-2 Arecoline