63612-50-0,MFCD00864670
Catalog No.:AA01CBMS

63612-50-0 | 2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
95%
in stock  
$18.00   $13.00
- +
100mg
95%
in stock  
$40.00   $28.00
- +
500mg
≥98%
in stock  
$72.00   $50.00
- +
1g
95%
in stock  
$121.00   $85.00
- +
5g
95%
in stock  
$415.00   $290.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01CBMS
Chemical Name:
2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
CAS Number:
63612-50-0
Molecular Formula:
C12H10F3N3O4
Molecular Weight:
317.2207
MDL Number:
MFCD00864670
SMILES:
O=C1NC(C(=O)N1c1ccc(c(c1)C(F)(F)F)[N+](=O)[O-])(C)C
NSC Number:
758683
Properties
Computed Properties
 
Complexity:
515  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2  

Literature

Title: TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer.

Journal: Toxicology and applied pharmacology 20160915

Title: In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer.

Journal: Molecular endocrinology (Baltimore, Md.) 20121101

Title: Discovery of diarylhydantoins as new selective androgen receptor modulators.

Journal: Journal of medicinal chemistry 20121011

Title: Steroid derivatives as pure antagonists of the androgen receptor.

Journal: The Journal of steroid biochemistry and molecular biology 20121001

Title: Nilutamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: Anti-androgen effects of cypermethrin on the amino- and carboxyl-terminal interaction of the androgen receptor.

Journal: Toxicology 20120226

Title: Current and emerging treatment options for castration-resistant prostate cancer: a focus on immunotherapy.

Journal: Journal of clinical immunology 20120201

Title: N-[3-(4-Fluoro-benz-yl)-2,4-dioxo-1,3-diaza-spiro-[4.5]dec-8-yl]-2-methyl-benzene-sulfonamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-meth-oxy-benzene-sulfonamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: Redefining hormone sensitive disease in advanced prostate cancer.

Journal: Advances in urology 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.

Journal: Journal of medicinal chemistry 20110922

Title: Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Journal: Environmental health perspectives 20110801

Title: Efficacy of alternative antiandrogen therapy for prostate cancer that relapsed after initial maximum androgen blockade.

Journal: Korean journal of urology 20110701

Title: N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-methyl-benzamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: Two panels of steroid receptor luciferase reporter cell lines for compound profiling.

Journal: Combinatorial chemistry & high throughput screening 20110501

Title: Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

Journal: The Prostate 20110401

Title: Castration-resistant prostate cancer: targeted therapies and individualized treatment.

Journal: The oncologist 20110301

Title: Current treatment strategies for castration-resistant prostate cancer.

Journal: Korean journal of urology 20110301

Title: Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway.

Journal: Archives of biochemistry and biophysics 20110215

Title: Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies.

Journal: Journal of medicinal chemistry 20110113

Title: Neoadjuvant androgen deprivation for prostate volume reduction: the optimal duration in prostate cancer radiotherapy.

Journal: Urologic oncology 20110101

Title: Sipuleucel-T for therapy of asymptomatic or minimally symptomatic, castrate-refractory prostate cancer: an update and perspective among other treatments.

Journal: OncoTargets and therapy 20110101

Title: Six-month gonadotropin releasing hormone (GnRH) agonist depots provide efficacy, safety, convenience, and comfort.

Journal: Cancer management and research 20110101

Title: Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.

Journal: Journal of medical case reports 20110101

Title: Resistance to cancer treatment: the role of somatic genetic events and the challenges for targeted therapies.

Journal: Frontiers in pharmacology 20110101

Title: New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.

Journal: Prostate cancer 20110101

Title: Effect of Turkish propolis extracts on proteome of prostate cancer cell line.

Journal: Proteome science 20110101

Title: Efficacy and safety of gonadotropin-releasing hormone agonists used in the treatment of prostate cancer.

Journal: Drug, healthcare and patient safety 20110101

Title: Molecular targets for radiation oncology in prostate cancer.

Journal: Frontiers in oncology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice.

Journal: The Journal of antimicrobial chemotherapy 20100901

Title: Words of wisdom. Re: Does oral antiandrogen use before leuteinizing hormone-releasing therapy in patients with metastatic prostate cancer prevent clinical consequences of a testosterone flare? Oh WK, Landrum MB, Lamont EB, et al. Urology 2010;75:642-7.

Journal: European urology 20100801

Title: Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells.

Journal: FEBS letters 20100603

Title: Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway.

Journal: Endocrinology 20100401

Title: Growth inhibition of androgen-responsive prostate cancer cells with brefeldin A targeting cell cycle and androgen receptor.

Journal: Journal of biomedical science 20100101

Title: A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899.

Journal: Journal of translational medicine 20100101

Title: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model.

Journal: Biology direct 20100101

Title: Maximal androgen blockade for advanced prostate cancer.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20100101

Title: Hormonal therapy of prostate cancer.

Journal: Progress in brain research 20100101

Title: Alternative strategies for the treatment of classical congenital adrenal hyperplasia: pitfalls and promises.

Journal: International journal of pediatric endocrinology 20100101

Title: Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.

Journal: Proteome science 20100101

Title: Fasting and cancer treatment in humans: A case series report.

Journal: Aging 20091201

Title: Efficacy of salvage radiotherapy plus 2-year androgen suppression for postradical prostatectomy patients with PSA relapse.

Journal: International journal of radiation oncology, biology, physics 20091115

Title: Prospective study evaluating postoperative radiotherapy plus 2-year androgen suppression for post-radical prostatectomy patients with pathologic T3 disease and/or positive surgical margins.

Journal: International journal of radiation oncology, biology, physics 20091001

Title: Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening.

Journal: PLoS computational biology 20090601

Title: Fulminant hepatic failure due to nilutamide hepatotoxicity.

Journal: Digestive diseases and sciences 20090401

Title: CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer.

Journal: British journal of cancer 20090310

Title: Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men.

Journal: International journal of andrology 20090201

Title: Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line.

Journal: Toxicology 20090108

Title: Role of maximum androgen blockade in advanced prostate cancer.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20090101

Title: Watchful waiting beats androgen deprivation therapy in early prostate cancer.

Journal: Journal of the National Cancer Institute 20081105

Title: Testosterone recovery after prolonged androgen suppression in patients with prostate cancer.

Journal: The Journal of urology 20081001

Title: Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080715

Title: Antiandrogen withdrawal in castrate-refractory prostate cancer: a Southwest Oncology Group trial (SWOG 9426).

Journal: Cancer 20080601

Title: Delayed dark adaptation caused by nilutamide.

Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20080601

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology 20080401

Title: Maximal androgen blockade for advanced prostate cancer.

Journal: Best practice & research. Clinical endocrinology & metabolism 20080401

Title: Synthesis and structure-activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide.

Journal: Journal of medicinal chemistry 20080327

Title: The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens.

Journal: BMC cell biology 20080101

Title: FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects.

Journal: BMC bioinformatics 20080101

Title: Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects.

Journal: PloS one 20080101

Title: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature.

Journal: Journal of hematology & oncology 20080101

Title: Strategies for prostate cancer prevention: Review of the literature.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20080101

Title: Role of vaccine therapy in cancer: biology and practice.

Journal: Current oncology (Toronto, Ont.) 20071201

Title: Combined androgen blockade in advanced prostate cancer: looking back to move forward.

Journal: Clinical genitourinary cancer 20070901

Title: A bifunctional colchicinoid that binds to the androgen receptor.

Journal: Molecular cancer therapeutics 20070801

Title: A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells.

Journal: Molecular cancer therapeutics 20070701

Title: Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.

Journal: The Prostate 20070601

Title: Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localized prostate cancer (T1-2): a retrospective study.

Journal: Asian journal of andrology 20070301

Title: Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor.

Journal: Biochemical and biophysical research communications 20070216

Title: Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay.

Journal: Chemosphere 20070101

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: New therapeutic targets in the treatment of prostate cancer.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20070101

Title: Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones.

Journal: Molecular pharmacology 20061201

Title: Role of 5 alpha-reductase inhibitors in the management of prostate cancer.

Journal: Clinical interventions in aging 20061201

Title: Bioactivation and hepatotoxicity of nitroaromatic drugs.

Journal: Current drug metabolism 20061001

Title: [Keyrole of endocrinology in the victory against prostate cancer].

Journal: Bulletin du cancer 20060901

Title: Antiandrogen treatments in locally advanced prostate cancer: are they all the same?

Journal: Journal of cancer research and clinical oncology 20060801

Title: GREB1 is a novel androgen-regulated gene required for prostate cancer growth.

Journal: The Prostate 20060601

Title: Maximal androgen blockade for the treatment of metastatic prostate cancer--a systematic review.

Journal: Current oncology (Toronto, Ont.) 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Combined androgen blockade: an update.

Journal: The Urologic clinics of North America 20060501

Title: Recent progress in hormonal therapy for advanced prostate cancer.

Journal: Current opinion in urology 20060501

Title: Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3.

Journal: Pharmaceutical research 20060401

Title: Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells.

Journal: Fertility and sterility 20060401

Title: Metabolism of nilutamide in rat lung.

Journal: Biochemical pharmacology 20060112

Title: Androgen receptor activities of p,p'-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay.

Journal: Toxicology letters 20060105

Title: The role of steroids in follicular growth.

Journal: Reproductive biology and endocrinology : RB&E 20060101

Title: Prostate cancer PET bioprobes: synthesis of [18F]-radiolabeled hydroxyflutamide derivatives.

Journal: Bioorganic & medicinal chemistry 20051115

Title: Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro.

Journal: Free radical biology & medicine 20051001

Title: Efficacy of nilutamide as secondary hormonal therapy in androgen-independent prostate cancer.

Journal: BJU international 20051001

Title: A phase II study of nilutamide in men with prostate cancer after the failure of flutamide or bicalutamide therapy.

Journal: BJU international 20051001

Title: Nontranscriptional regulation of cardiac repolarization currents by testosterone.

Journal: Circulation 20050920

Title: Long-term side-effects of intermittent androgen suppression therapy in prostate cancer: results of a phase II study.

Journal: BJU international 20050901

Title: Antiandrogen, vaccine and combination therapy in patients with nonmetastatic hormone refractory prostate cancer.

Journal: The Journal of urology 20050801

Title: [From the finger to the eye!...].

Journal: La Revue de medecine interne 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Intermittent androgen deprivation for biologic recurrence after radical prostatectomy: long-term experience.

Journal: Urology 20050401

Title: Combined androgen blockade: the case for bicalutamide.

Journal: Clinical prostate cancer 20050301

Title: Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.

Journal: Journal of medicinal chemistry 20050224

Title: How are hemoglobin levels affected by androgen deprivation in non-metastatic prostate cancer patients?

Journal: The Canadian journal of urology 20050201

Title: Prolonged response to nilutamide in a patient with stage D0.5 prostate cancer who previously failed androgen deprivation therapy.

Journal: American journal of therapeutics 20050101

Title: Major impact of hormonal therapy in localized prostate cancer--death can already be an exception.

Journal: The Journal of steroid biochemistry and molecular biology 20041201

Title: Distribution of nitroreductive activity toward nilutamide in rat.

Journal: Toxicology and applied pharmacology 20041115

Title: Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera.

Journal: Journal of medicinal chemistry 20041104

Title: Monotherapy in advanced prostate cancer: an overview.

Journal: Experimental oncology 20040901

Title: Interstitial lung disease associated with drug therapy.

Journal: British journal of cancer 20040801

Title: Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040601

Title: Antiandrogen monotherapy: recommendations for the treatment of prostate cancer.

Journal: Urologia internationalis 20040101

Title: Vaccine therapy for a patient with androgen-insensitive prostate cancer without evidence of measurable disease on scans.

Journal: American journal of therapeutics 20040101

Title: Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug.

Journal: Chemical research in toxicology 20031201

Title: [Fatal fulminating hepatitis induced by nilutamide].

Journal: Gastroenterologie clinique et biologique 20031201

Title: Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate.

Journal: Journal of medicinal chemistry 20031120

Title: Steroids control the aromatase gene expression in purified germ cells from the adult male rat.

Journal: Journal of molecular endocrinology 20030801

Title: Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails.

Journal: The Journal of urology 20030501

Title: The role of antiandrogen monotherapy in the treatment of prostate cancer.

Journal: BJU international 20030301

Title: Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.

Journal: Molecular pharmacology 20030101

Title: Therapeutic androgen receptor ligands.

Journal: Nuclear receptor signaling 20030101

Title: The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer.

Journal: British journal of cancer 20021118

Title: Pneumonitis associated with nonsteroidal antiandrogens: presumptive evidence of a class effect.

Journal: Annals of internal medicine 20021001

Title: Antiandrogen monotherapy: indications and results.

Journal: Urology 20020901

Title: Prognostic factor analysis in patients with advanced prostate cancer treated by castration plus anandron or placebo: a final update.

Journal: European urology 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: [The role of bicalutamide in the treatment of prostate cancer].

Journal: Harefuah 20020401

Title: Flavonoids can block PSA production by breast and prostate cancer cell lines.

Journal: Clinica chimica acta; international journal of clinical chemistry 20020301

Title: [Respiratory side-effects of drugs].

Journal: Nederlands tijdschrift voor geneeskunde 20020126

Title: Nilutamide: possible utility as a second-line hormonal agent.

Journal: Urology 20011201

Title: Nilutamide-induced neutropenia.

Journal: BJU international 20011101

Title: Antiandrogen monotherapy: a new form of treatment for patients with prostate cancer.

Journal: Urology 20010801

Title: Why phase III trials of maximal androgen blockade versus castration in M1 prostate cancer rarely show statistically significant differences.

Journal: The Prostate 20010615

Title: Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.

Journal: Journal of medicinal chemistry 20010524

Title: Combined androgen blockade with nonsteroidal antiandrogens for advanced prostate cancer: a systematic review.

Journal: Urology 20010401

Title: Nonsteroidal antiandrogens: a therapeutic option for patients with advanced prostate cancer who wish to retain sexual interest and function.

Journal: BJU international 20010101

Title: Neither fibroblast growth factor-1 nor fibroblast growth factor-2 is an androgen receptor coactivator in androgen-resistant prostate cancer.

Journal: Molecular urology 20010101

Title: Androgen deprivation and other treatments for advanced prostate cancer.

Journal: Reviews in urology 20010101

Title: Flare Associated with LHRH-Agonist Therapy.

Journal: Reviews in urology 20010101

Title: Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2.

Journal: Endocrinology 20000201

Title: Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters.

Journal: Urology 19970401

Title: Is there a role for pure antiandrogens in the treatment of advanced prostatic cancer?

Journal: Progress in clinical and biological research 19900101

Title: Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3(1):9-25.

Title: Ask K, et al. Metabolism of nilutamide in rat lung. Biochem Pharmacol. 2006 Jan 12;71(3):377-85.

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Tags:63612-50-0 Molecular Formula|63612-50-0 MDL|63612-50-0 SMILES|63612-50-0 2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
Catalog No.: AA01CBMS
63612-50-0,MFCD00864670
63612-50-0 | 2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
Pack Size: 25mg
Purity: 95%
in stock
$18.00 $13.00
Pack Size: 100mg
Purity: 95%
in stock
$40.00 $28.00
Pack Size: 500mg
Purity: ≥98%
in stock
$72.00 $50.00
Pack Size: 1g
Purity: 95%
in stock
$121.00 $85.00
Pack Size: 5g
Purity: 95%
in stock
$415.00 $290.00
Quantity
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Technical Information
Catalog Number: AA01CBMS
Chemical Name: 2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
CAS Number: 63612-50-0
Molecular Formula: C12H10F3N3O4
Molecular Weight: 317.2207
MDL Number: MFCD00864670
SMILES: O=C1NC(C(=O)N1c1ccc(c(c1)C(F)(F)F)[N+](=O)[O-])(C)C
NSC Number: 758683
Properties
Complexity: 515  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2  
Literature fold

Title: TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer.

Journal: Toxicology and applied pharmacology20160915

Title: In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer.

Journal: Molecular endocrinology (Baltimore, Md.)20121101

Title: Discovery of diarylhydantoins as new selective androgen receptor modulators.

Journal: Journal of medicinal chemistry20121011

Title: Steroid derivatives as pure antagonists of the androgen receptor.

Journal: The Journal of steroid biochemistry and molecular biology20121001

Title: Nilutamide.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: Anti-androgen effects of cypermethrin on the amino- and carboxyl-terminal interaction of the androgen receptor.

Journal: Toxicology20120226

Title: Current and emerging treatment options for castration-resistant prostate cancer: a focus on immunotherapy.

Journal: Journal of clinical immunology20120201

Title: N-[3-(4-Fluoro-benz-yl)-2,4-dioxo-1,3-diaza-spiro-[4.5]dec-8-yl]-2-methyl-benzene-sulfonamide.

Journal: Acta crystallographica. Section E, Structure reports online20120101

Title: N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-meth-oxy-benzene-sulfonamide.

Journal: Acta crystallographica. Section E, Structure reports online20120101

Title: Redefining hormone sensitive disease in advanced prostate cancer.

Journal: Advances in urology20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.

Journal: Journal of medicinal chemistry20110922

Title: Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Journal: Environmental health perspectives20110801

Title: Efficacy of alternative antiandrogen therapy for prostate cancer that relapsed after initial maximum androgen blockade.

Journal: Korean journal of urology20110701

Title: N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-methyl-benzamide.

Journal: Acta crystallographica. Section E, Structure reports online20110601

Title: Two panels of steroid receptor luciferase reporter cell lines for compound profiling.

Journal: Combinatorial chemistry & high throughput screening20110501

Title: Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

Journal: The Prostate20110401

Title: Castration-resistant prostate cancer: targeted therapies and individualized treatment.

Journal: The oncologist20110301

Title: Current treatment strategies for castration-resistant prostate cancer.

Journal: Korean journal of urology20110301

Title: Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway.

Journal: Archives of biochemistry and biophysics20110215

Title: Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies.

Journal: Journal of medicinal chemistry20110113

Title: Neoadjuvant androgen deprivation for prostate volume reduction: the optimal duration in prostate cancer radiotherapy.

Journal: Urologic oncology20110101

Title: Sipuleucel-T for therapy of asymptomatic or minimally symptomatic, castrate-refractory prostate cancer: an update and perspective among other treatments.

Journal: OncoTargets and therapy20110101

Title: Six-month gonadotropin releasing hormone (GnRH) agonist depots provide efficacy, safety, convenience, and comfort.

Journal: Cancer management and research20110101

Title: Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.

Journal: Journal of medical case reports20110101

Title: Resistance to cancer treatment: the role of somatic genetic events and the challenges for targeted therapies.

Journal: Frontiers in pharmacology20110101

Title: New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.

Journal: Prostate cancer20110101

Title: Effect of Turkish propolis extracts on proteome of prostate cancer cell line.

Journal: Proteome science20110101

Title: Efficacy and safety of gonadotropin-releasing hormone agonists used in the treatment of prostate cancer.

Journal: Drug, healthcare and patient safety20110101

Title: Molecular targets for radiation oncology in prostate cancer.

Journal: Frontiers in oncology20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice.

Journal: The Journal of antimicrobial chemotherapy20100901

Title: Words of wisdom. Re: Does oral antiandrogen use before leuteinizing hormone-releasing therapy in patients with metastatic prostate cancer prevent clinical consequences of a testosterone flare? Oh WK, Landrum MB, Lamont EB, et al. Urology 2010;75:642-7.

Journal: European urology20100801

Title: Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells.

Journal: FEBS letters20100603

Title: Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway.

Journal: Endocrinology20100401

Title: Growth inhibition of androgen-responsive prostate cancer cells with brefeldin A targeting cell cycle and androgen receptor.

Journal: Journal of biomedical science20100101

Title: A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899.

Journal: Journal of translational medicine20100101

Title: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model.

Journal: Biology direct20100101

Title: Maximal androgen blockade for advanced prostate cancer.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India20100101

Title: Hormonal therapy of prostate cancer.

Journal: Progress in brain research20100101

Title: Alternative strategies for the treatment of classical congenital adrenal hyperplasia: pitfalls and promises.

Journal: International journal of pediatric endocrinology20100101

Title: Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.

Journal: Proteome science20100101

Title: Fasting and cancer treatment in humans: A case series report.

Journal: Aging20091201

Title: Efficacy of salvage radiotherapy plus 2-year androgen suppression for postradical prostatectomy patients with PSA relapse.

Journal: International journal of radiation oncology, biology, physics20091115

Title: Prospective study evaluating postoperative radiotherapy plus 2-year androgen suppression for post-radical prostatectomy patients with pathologic T3 disease and/or positive surgical margins.

Journal: International journal of radiation oncology, biology, physics20091001

Title: Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening.

Journal: PLoS computational biology20090601

Title: Fulminant hepatic failure due to nilutamide hepatotoxicity.

Journal: Digestive diseases and sciences20090401

Title: CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer.

Journal: British journal of cancer20090310

Title: Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men.

Journal: International journal of andrology20090201

Title: Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line.

Journal: Toxicology20090108

Title: Role of maximum androgen blockade in advanced prostate cancer.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India20090101

Title: Watchful waiting beats androgen deprivation therapy in early prostate cancer.

Journal: Journal of the National Cancer Institute20081105

Title: Testosterone recovery after prolonged androgen suppression in patients with prostate cancer.

Journal: The Journal of urology20081001

Title: Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080715

Title: Antiandrogen withdrawal in castrate-refractory prostate cancer: a Southwest Oncology Group trial (SWOG 9426).

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Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society20080601

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology20080401

Title: Maximal androgen blockade for advanced prostate cancer.

Journal: Best practice & research. Clinical endocrinology & metabolism20080401

Title: Synthesis and structure-activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide.

Journal: Journal of medicinal chemistry20080327

Title: The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens.

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Title: Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects.

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Title: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature.

Journal: Journal of hematology & oncology20080101

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Title: Combined androgen blockade in advanced prostate cancer: looking back to move forward.

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Title: A bifunctional colchicinoid that binds to the androgen receptor.

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Title: A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells.

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Title: Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.

Journal: The Prostate20070601

Title: Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localized prostate cancer (T1-2): a retrospective study.

Journal: Asian journal of andrology20070301

Title: Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor.

Journal: Biochemical and biophysical research communications20070216

Title: Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay.

Journal: Chemosphere20070101

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology20070101

Title: New therapeutic targets in the treatment of prostate cancer.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India20070101

Title: Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones.

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Title: Role of 5 alpha-reductase inhibitors in the management of prostate cancer.

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Title: Antiandrogen treatments in locally advanced prostate cancer: are they all the same?

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Title: GREB1 is a novel androgen-regulated gene required for prostate cancer growth.

Journal: The Prostate20060601

Title: Maximal androgen blockade for the treatment of metastatic prostate cancer--a systematic review.

Journal: Current oncology (Toronto, Ont.)20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Combined androgen blockade: an update.

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Title: Recent progress in hormonal therapy for advanced prostate cancer.

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Title: Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3.

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Title: Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells.

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Journal: Biochemical pharmacology20060112

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Title: The role of steroids in follicular growth.

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Journal: Bioorganic & medicinal chemistry20051115

Title: Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro.

Journal: Free radical biology & medicine20051001

Title: Efficacy of nilutamide as secondary hormonal therapy in androgen-independent prostate cancer.

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