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63675-72-9,MFCD00478055
Catalog No.:AA003T1M

63675-72-9 | Nisoldipine

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1mg
97%
in stock  
$6.00   $4.00
- +
100mg
97%
in stock  
$8.00   $6.00
- +
250mg
97%
in stock  
$13.00   $9.00
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1g
97%
in stock  
$17.00   $12.00
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5g
98%
in stock  
$64.00   $45.00
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10g
98%
in stock  
$112.00   $78.00
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25g
97%
in stock  
$180.00   $126.00
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100g
97%
in stock  
$543.00   $380.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003T1M
Chemical Name:
Nisoldipine
CAS Number:
63675-72-9
Molecular Formula:
C20H24N2O6
Molecular Weight:
388.4144
MDL Number:
MFCD00478055
SMILES:
COC(=O)C1=C(C)NC(=C(C1c1ccccc1[N+](=O)[O-])C(=O)OCC(C)C)C
NSC Number:
759106
Properties
Properties
 
Form:
Solid  
MP:
147-148°C  
Solubility:
DMSO: >10mg/mL  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
704  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.3  

Literature

Title: Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Journal: Scientific reports 20140101

Title: FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.

Journal: Chemico-biological interactions 20130905

Title: Role of action potential configuration and the contribution of C²⁺a and K⁺ currents to isoprenaline-induced changes in canine ventricular cells.

Journal: British journal of pharmacology 20121001

Title: Anti-arrhythmic and hemodynamic effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine.

Journal: Pharmacological research 20121001

Title: Tetrodotoxin blocks L-type Ca2+ channels in canine ventricular cardiomyocytes.

Journal: Pflugers Archiv : European journal of physiology 20120801

Title: The inhibitory effects of m-nisoldipine on the 5-hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells via Ca2+ antagonism and antioxidant mechanisms.

Journal: European journal of pharmacology 20120705

Title: Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients.

Journal: CNS neuroscience & therapeutics 20120501

Title: Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Simultaneous determination of m-nisoldipine and its three metabolites in rat plasma by liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101101

Title: Preparation of a novel glycidyl methacrylate-based monolith and its application for the determination of m-nisoldipine in human plasma.

Journal: Journal of chromatographic science 20100701

Title: The RAAS in the pathogenesis and treatment of diabetic nephropathy.

Journal: Nature reviews. Nephrology 20100601

Title: Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes.

Journal: The Journal of membrane biology 20100601

Title: [Effect of m-nisoldipine on the Ca2+/CaM/CaN signal pathway in 5-HT-induced proliferation of rat PASMCs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100101

Title: Capillary electrophoretic enantioseparation of m-nisoldipine using two different beta-cyclodextrins.

Journal: Journal of separation science 20090901

Title: Calcium channel blocker-associated small bowel angioedema.

Journal: Journal of clinical gastroenterology 20090401

Title: Serum phosphorus and cardiovascular mortality in type 2 diabetes.

Journal: The American journal of medicine 20090401

Title: Tissues distribution of R-(-)- and S-(+)-m-nisoldipine after single enantiomer administration in rats.

Journal: Drug development and industrial pharmacy 20090101

Title: Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes.

Journal: European journal of pharmacology 20081119

Title: Gingival hyperplasia in a patient with hypertension.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20081101

Title: m-Nisoldipine attenuates monocrotaline-induced pulmonary hypertension by suppressing 5-HT/ERK MAPK pathway.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081001

Title: T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers.

Journal: Life sciences 20080312

Title: Nisoldipine exposures.

Journal: The American journal of emergency medicine 20080301

Title: Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects.

Journal: Heart and vessels 20071101

Title: Telmisartan improves endothelial function in patients with essential hypertension.

Journal: Journal of cardiovascular pharmacology 20071001

Title: Adenoviral-mediated expression of dihydropyridine-insensitive L-type calcium channels in cardiac ventricular myocytes and fibroblasts.

Journal: European journal of pharmacology 20070622

Title: Pharmacologic agents in the management of hypertension--nisoldipine coat-core.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20070401

Title: Mobilization of putative high-proliferative-potential endothelial colony-forming cells during antihypertensive treatment in patients with essential hypertension.

Journal: Stem cells and development 20070401

Title: Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension.

Journal: Journal of clinical pharmacology 20070301

Title: Simple and sensitive determination of nisoldipine in plasma using liquid chromatography-tandem mass spectrometry.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20061201

Title: Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension.

Journal: Metabolism: clinical and experimental 20060901

Title: Validated LC-MS-MS method for determination of m-nisoldipine polymorphs in rat plasma and its application to pharmacokinetic studies.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: An overview on the homeostasis of Ca2+ in chemoreceptor cells of the rabbit and rat carotid bodies.

Journal: Advances in experimental medicine and biology 20060101

Title: Thermal stability of 1,4-dihydropyridine derivatives in solid state.

Journal: Acta poloniae pharmaceutica 20060101

Title: Photoprotection of 1,4-dihydropyridine derivatives by dyes.

Journal: International journal of pharmaceutics 20051104

Title: Subtype switching of L-Type Ca 2+ channel from Cav1.3 to Cav1.2 in embryonic murine ventricle.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20051101

Title: Evaluation of titanium dioxide as a pharmaceutical excipient for preformulation of a photo-labile drug: effect of physicochemical properties on the photostability of solid-state nisoldipine.

Journal: Chemical & pharmaceutical bulletin 20050701

Title: Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo.

Journal: Neuroscience letters 20050603

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: The effect of beta-carotene on the photostability of nisoldipine.

Journal: Methods and findings in experimental and clinical pharmacology 20050401

Title: Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells.

Journal: The Journal of physiology 20050301

Title: Role of nitric oxide in Ca2+ sensitivity of the slowly activating delayed rectifier K+ current in cardiac myocytes.

Journal: Circulation research 20050107

Title: Effects of a mononitrate, a beta1-blocker and a dihydropyridine calcium channel blocker on cardiovascular responsiveness to passive orthostasis: a placebo-controlled double-blind study in normotensive volunteers.

Journal: Arzneimittel-Forschung 20050101

Title: [Toxicological analysis of selected 1,4-dihydropyridine calcium channel blockers in the diagnosis of intoxications].

Journal: Archiwum medycyny sadowej i kryminologii 20050101

Title: Effects of nanomolar concentration dihydroouabain on calcium current and intracellular calcium in guinea pig ventricular myocytes.

Journal: Life sciences 20041224

Title: Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.

Journal: Cell 20041001

Title: High-performance liquid chromatography-electrospray ionization mass spectrometric determination of nisoldipine in human plasma.

Journal: Journal of chromatographic science 20041001

Title: Cholecystokinin octapeptide increases free intracellular calcium of guinea pig cardiomyocytes through activation of Ca2+ channel and tyrosine kinase.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20040225

Title: Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine.

Journal: British journal of pharmacology 20031101

Title: Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

Journal: The Journal of biological chemistry 20031017

Title: Comparative efficacy and safety of nisoldipine extended-release (ER) and amlodipine (CESNA-III study) in African American patients with hypertension.

Journal: American journal of hypertension 20030901

Title: Photochemical degradation of solid-state nisoldipine monitored by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20030808

Title: Long term effects of nisoldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study.

Journal: Heart (British Cardiac Society) 20030801

Title: Differential effects of antihypertensive agents on electrocardiographic voltage: results from the Appropriate Blood Pressure Control in Diabetes (ABCD) trial.

Journal: American heart journal 20030601

Title: Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp.

Journal: Cardiovascular research 20030401

Title: An updated meta-analysis of calcium-channel blockers in the prevention of restenosis after coronary angioplasty.

Journal: American heart journal 20030301

Title: Intensive blood pressure control reduces the risk of cardiovascular events in patients with peripheral arterial disease and type 2 diabetes.

Journal: Circulation 20030211

Title: Comparison of effects of nisoldipine-extended release and amlodipine in patients with systemic hypertension and chronic stable angina pectoris.

Journal: The American journal of cardiology 20030201

Title: Reactivity of 1,4-dihydropyridines toward alkyl, alkylperoxyl radicals, and ABTS radical cation.

Journal: Chemical research in toxicology 20030201

Title: Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus.

Journal: European journal of clinical pharmacology 20021201

Title: Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells.

Journal: The Journal of biological chemistry 20021122

Title: Increased cyclosporine blood levels after nisoldipine administration in a renal transplant recipient.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20021101

Title: Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.

Journal: Acta physiologica Scandinavica 20020901

Title: Developmental changes of Ca(2+) handling in mouse ventricular cells from early embryo to adulthood.

Journal: Life sciences 20020802

Title: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020801

Title: L-type Ca2+ channels of the embryonic mouse heart.

Journal: European journal of pharmacology 20020705

Title: Hydrolytic degradation of nitrendipine and nisoldipine.

Journal: Journal of pharmaceutical and biomedical analysis 20020601

Title: [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020501

Title: Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis.

Journal: Cardiovascular research 20020501

Title: [Blood pressure amplitude in the morning must be reduced. Saving the hypertensive patient from infarct].

Journal: MMW Fortschritte der Medizin 20020307

Title: Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes.

Journal: Kidney international 20020301

Title: Interaction of digoxin with antihypertensive drugs via MDR1.

Journal: Life sciences 20020215

Title: Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide.

Journal: Pharmacological research 20020101

Title: Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats.

Journal: American journal of physiology. Heart and circulatory physiology 20011201

Title: Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders.

Journal: Journal of oral science 20011201

Title: Cardiac remodeling after long term norepinephrine treatment in rats.

Journal: Cardiovascular research 20011101

Title: Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.

Journal: Acta physiologica Scandinavica 20011101

Title: Enantioselective assay of nisoldipine in human plasma by chiral high-performance liquid chromatography combined with gas chromatographic-mass spectrometry: applications to pharmacokinetics.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011005

Title: Decrease in the Ca2+-activated K+ current of pulmonary arterial smooth muscle in pulmonary hypertension rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010901

Title: Selectivity of blocking of low- versus high-voltage activated calcium currents by the dihydropyridine derivatives Bay E5759 and Bay A4339 in neuroblastoma--glioma NG 108-15 cells.

Journal: Pharmacological research 20010801

Title: Nisoldipine increases the bioavailability of endothelial NO.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010801

Title: Comparison of 24-hour blood pressure profiles in patients with hypertension who were switched from amlodipine to nisoldipine.

Journal: Pharmacotherapy 20010801

Title: Mechanisms of coronary artery depolarization by uridine triphosphate.

Journal: American journal of physiology. Heart and circulatory physiology 20010601

Title: Control of secretion by mitochondria depends on the size of the local [Ca2+] after chromaffin cell stimulation.

Journal: The European journal of neuroscience 20010601

Title: The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes.

Journal: Cardiovascular research 20010301

Title: Usefulness of Nisoldipine for prevention of restenosis after percutaneous transluminal coronary angioplasty (results of the NICOLE study). NIsoldipine in COronary artery disease in LEuven.

Journal: The American journal of cardiology 20010101

Title: A prospective comparison of four antihypertensive agents in daily clinical practice.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20010101

Title: Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.

Journal: The Journal of biological chemistry 20001215

Title: Differential remodeling of the left and right heart after norepinephrine treatment in rats: studies on cytokines and collagen.

Journal: Journal of molecular and cellular cardiology 20000201

Title: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions.

Journal: European journal of clinical pharmacology 20000101

Title: Differential effects of morning and evening dosing of nisoldipine ER on circadian blood pressure and heart rate.

Journal: American journal of hypertension 19990801

Title: Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.

Journal: Heart disease (Hagerstown, Md.) 19990101

Title: Nisoldipine selectively induces coronary vasodilation and improves mild myocardial ischemia in dogs: a potential role of cellular acidosis.

Journal: Cardiovascular drugs and therapy 19981201

Title: A comparison of nisoldipine coat-core and felodipine in the treatment of mild-to-moderate hypertension.

Journal: International journal of clinical practice 19980601

Title: Protective effect of nisoldipine on dipyridamole-induced myocardial ischemia: correlation with exercise electrocardiography.

Journal: Coronary artery disease 19980101

Title: New evidence on the prevention of cardiovascular events in hypertensive patients with type 2 diabetes.

Journal: Journal of cardiovascular pharmacology 19980101

Title: Nisoldipine CC and lisinopril alone or in combination for treatment of mild to moderate systemic hypertension. Canadian Nisoldipine CC Hypertension Trial Group.

Journal: Cardiovascular drugs and therapy 19970901

Title: Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease.

Journal: Angiology 19970601

Title: Efficacy and tolerability of nisoldipine coat-core formulation in the treatment of essential hypertension: The South African Multicenter ANCHOR Study. Ambulatory Nisoldipine Coat-Core Hypertension Outpatient Response (ANCHOR) Investigators.

Journal: American journal of hypertension 19970301

Title: Effects of nisoldipine and/or enalapril on left ventricular function and exercise capacity in patients with recent anterior myocardial infarction and mild cardiac dysfunction.

Journal: American heart journal 19970301

Title: Nisoldipine CC: clinical experience in hypertension.

Journal: Cardiology 19970101

Title: Plasma endothelin-1 concentrations in patients with coronary artery disease during stress test before and after nisoldipine administration.

Journal: Acta cardiologica 19960101

Title: Nisoldipine improves ventricular function in rats with ischemic heart failure.

Journal: Journal of molecular and cellular cardiology 19950901

Title: The effects of nisoldipine on carotid artery stiffness and left ventricular functions.

Journal: Japanese heart journal 19950901

Title: Acute effects of intravenous nisoldipine on left ventricular function after acute myocardial infarction.

Journal: Cardiovascular drugs and therapy 19940501

Title: Cardiovascular effects of nisoldipine in essential hypertension.

Journal: Israel journal of medical sciences 19940201

Title: A proischaemic action of nisoldipine: relationship to a decrease in perfusion pressure and comparison to dipyridamole.

Journal: Cardiovascular research 19930701

Title: The acute effects of intravenous nisoldipine on left ventricular function within 24 h after acute myocardial infarction.

Journal: European heart journal 19921201

Title: Improved diastolic function with the calcium antagonist nisoldipine (coat-core) in patients post myocardial infarction: results of the DEFIANT study. Doppler Flow and Echocardiography in Functional cardiac Insufficiency: Assessment of Nisoldipine Therapy.

Journal: European heart journal 19921101

Title: Usefulness of oral nisoldipine for stable angina pectoris. The Nisoldipine Multicenter Angina Study Group.

Journal: The American journal of cardiology 19911015

Title: Effects of nisoldipine on stress-induced changes in haemodynamics and plasma catecholamines in normotensives and hypertensives.

Journal: Journal of human hypertension 19901201

Title: The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.

Journal: Cardiovascular drugs and therapy 19900801

Title: Hemodynamic mechanisms of antianginal action of calcium channel blocker nisoldipine in dynamic exercise-induced angina.

Journal: Circulation 19900601

Title: [Responses of plasma eicosanoids and hemodynamics to myocardial ischemia and the salutary effect of calcium entry blocker].

Journal: Nihon Ika Daigaku zasshi 19900201

Title: Nisoldipine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of angina pectoris, hypertension and related cardiovascular disorders.

Journal: Drugs 19881201

Title: The acute effects of intravenous nisoldipine on left ventricular function 24 to 72 hours after uncomplicated acute myocardial infarction.

Journal: Cardiovascular drugs and therapy 19881201

Title: Differential effects of 1,4-dihydropyridine calcium channel blockers: therapeutic implications.

Journal: Journal of clinical pharmacology 19871101

Title: Effects of nisoldipine on left ventricular function during exercise or cold pressor stress.

Journal: European heart journal 19871101

Title: Monotherapy with the calcium channel antagonist nisoldipine for systemic hypertension and comparison with diuretic drugs.

Journal: The American journal of cardiology 19870915

Title: Arrhythmogenic action of alpha 1-adrenoceptor stimulation in normoxic rat ventricular myocardium: influence of nisoldipine, reduced extracellular Ca2+ and ryanodine.

Journal: Journal of molecular and cellular cardiology 19870901

Title: Comparative antianginal effects of nisoldipine and nifedipine in patients with chronic stable angina.

Journal: American heart journal 19870201

Title: Renal effects of 1,4-dihydropyridines in animal models of hypertension and renal failure.

Journal: Journal of cardiovascular pharmacology 19870101

Title: The hypotensive effect of nisoldipine in renovascular hypertensive rats.

Journal: Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19861201

Title: Alteration of left ventricular diastolic filling in hypertensive patients: effects of nitrendipine and atenolol.

Journal: European heart journal 19860901

Title: Hamilton SF, Houle LM, Thadani U. Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure. Heart Dis. 1999 Nov-Dec;1(5):279-88.

Title: Fodor JG. Nisoldipine CC: efficacy and tolerability in hypertension and ischemic heart disease. Cardiovasc Drugs Ther. 1997 Jan;10 Suppl 3:873-9.

Title: D.J. Duncker, J.M. Hartog, P.G. Hugenholtz, et al. The effects of nisoldipine (Bay K 5552) on cardiovascular performance and regional blood flow in pentobarbital - anaesthetized pigs with or without β-adrenoceptor blockade. British Journal of Pharmacology. 1986,88(1): 9-18

Title: Jan W. De Jong, Tom Huizer, Jan G.P. Tijssen. Energy conservation by nisoldipine in ischaemic heart. British Journal of Pharmacology. 1984, 83(4): 943-949

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Tags:63675-72-9 Molecular Formula|63675-72-9 MDL|63675-72-9 SMILES|63675-72-9 Nisoldipine