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Home Amines 641571-10-0
641571-10-0,MFCD09833716
Catalog No.:AA0036TM

641571-10-0 | 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$24.00   $17.00
- +
250mg
98%
in stock  
$29.00   $21.00
- +
1g
98%
in stock  
$78.00   $55.00
- +
5g
98%
in stock  
$295.00   $206.00
- +
10g
98%
in stock  
$369.00   $259.00
- +
25g
98%
in stock  
$809.00   $567.00
- +
100g
98%
in stock  
$2,140.00   $1,498.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0036TM
Chemical Name:
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide
CAS Number:
641571-10-0
Molecular Formula:
C28H22F3N7O
Molecular Weight:
529.5158
MDL Number:
MFCD09833716
SMILES:
Cc1ncn(c1)c1cc(NC(=O)c2ccc(c(c2)Nc2nccc(n2)c2cccnc2)C)cc(c1)C(F)(F)F
NSC Number:
747599
Properties
Properties
 
Form:
Solid  
MP:
231-233°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
817  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.9  

Upstream Synthesis Route

[1]Patent:WO2007/15870,2007,A2,.Locationinpatent:Page/Pagecolumn28

[2]Patent:WO2007/15871,2007,A1,.Locationinpatent:Page/Pagecolumn10-11

[3]Patent:WO2007/15870,2007,A2,.Locationinpatent:Page/Pagecolumn30

Downstream Synthesis Route

[1]Synthesis,2007,p.2121-2124

[2]OrganicandBiomolecularChemistry,2013,vol.11,p.1822-1839

[1]JournaloftheAmericanChemicalSociety,2012,vol.134,p.700-706

[2]Patent:CN106496193,2017,A.Locationinpatent:Paragraph0019-0027

[3]Patent:WO2006/135641,2006,A2.Locationinpatent:Page/Pagecolumn6;8-9

[4]Patent:WO2007/15870,2007,A2.Locationinpatent:Page/Pagecolumn36-37

[5]Patent:WO2007/15870,2007,A2.Locationinpatent:Page/Pagecolumn37-38

[1]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn13

[2]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn18-19

[3]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn14-15

[4]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn16-17

[5]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn14-15

[6]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn16

[1]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn12

[2]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn17-19

[3]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn14-15

[4]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn16-17

[5]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn14-15

[6]Patent:WO2007/15871,2007,A1.Locationinpatent:Page/Pagecolumn16

Literature

Title: Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.

Title: Sako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9(9):e107613.

Title: Dervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21(44):12576-85.

Title: Fujita KI, et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites. J Pharm Sci. 2017 Sep;106(9):2632-2641.

Title: Meirson T, et al. Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. Oncotarget. 2018 Apr 24;9(31):22158-22183.

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SDS
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Tags:641571-10-0 Molecular Formula|641571-10-0 MDL|641571-10-0 SMILES|641571-10-0 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide