Home Other Building Blocks 923288-90-8
923288-90-8,MFCD16038432
Catalog No.:AA003A50

923288-90-8 | Nilotinib hcl monohydrate

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Purity
Availability
Price(USD)
Quantity
  
250mg
≥98%
in stock  
$73.00   $51.00
- +
500mg
≥98%
in stock  
$139.00   $97.00
- +
1g
≥98%
in stock  
$233.00   $163.00
- +
5g
≥98%
in stock  
$722.00   $505.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003A50
Chemical Name:
Nilotinib hcl monohydrate
CAS Number:
923288-90-8
Molecular Formula:
C28H25ClF3N7O2
Molecular Weight:
583.9920
MDL Number:
MFCD16038432
SMILES:
Cc1ncn(c1)c1cc(NC(=O)c2ccc(c(c2)Nc2nccc(n2)c2cccnc2)C)cc(c1)C(F)(F)F.O.Cl
Properties
Computed Properties
 
Complexity:
817  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

Literature

Title: Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.

Title: Sako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9(9):e107613.

Title: Dervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21(44):12576-85.

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SDS
Tags:923288-90-8 Molecular Formula|923288-90-8 MDL|923288-90-8 SMILES|923288-90-8 Nilotinib hcl monohydrate