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99592-32-2,MFCD00918063
Catalog No.:AA0064TQ

99592-32-2 | 1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

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5mg
95%
1 week  
$118.00   $83.00
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10mg
95%
1 week  
$143.00   $100.00
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25mg
95%
1 week  
$204.00   $143.00
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50mg
95%
1 week  
$277.00   $194.00
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100mg
95%
1 week  
$386.00   $270.00
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200mg
95%
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$550.00   $385.00
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1g
95
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$929.00   $650.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0064TQ
Chemical Name:
1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
CAS Number:
99592-32-2
Molecular Formula:
C20H15Cl3N2OS
Molecular Weight:
437.7699
MDL Number:
MFCD00918063
SMILES:
Clc1ccc(c(c1)Cl)C(Cn1ccnc1)OCc1csc2c1cccc2Cl
Properties
Properties
 
Form:
Solid  
MP:
146-147℃  

Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
6.3  

Downstream Synthesis Route

[1]EuropeanJournalofMedicinalChemistry,1986,vol.21,p.329-332

[2]Arzneimittel-Forschung/DrugResearch,1992,vol.42,p.691-694

[3]Patent:WO2006/29812,2006,A1.Locationinpatent:Page/Pagecolumn6

99592-32-2   
CASUnavailable 

[1]CurrentPatentAssignee:FERRERINTERNACIONALSA-WO2006/29812,2006,A1Locationinpatent:Page/Pagecolumn7

99592-32-2   
CASUnavailable 
  583057-51-6 

[1]Podolska,Marzena;Białecka,Wanda;Kulik,Anna;Kwiatkowska-Puchniarz,Barbara;Mazurek,Aleksander[Actapoloniaepharmaceutica,2017,vol.74,#3,p.777-784]

[2]Abdel-Megied,AhmedM.;Hanafi,RashaS.;Aboul-Enein,HassanY.[Chirality,2018,vol.30,#2,p.165-176]

[1]Zhang,Lumin;Si,Xiaojia;Rominger,Frank;Hashmi,A.StephenK.[JournaloftheAmericanChemicalSociety,2020,vol.142,#23,p.10485-10493]

[1]Zhang,Lumin;Si,Xiaojia;Rominger,Frank;Hashmi,A.StephenK.[JournaloftheAmericanChemicalSociety,2020,vol.142,#23,p.10485-10493]

Literature

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Journal: PLoS computational biology 20111201

Title: Treatment of interdigital tinea pedis: once-daily therapy with sertaconazole nitrate.

Journal: Journal of drugs in dermatology : JDD 20111001

Title: An open-label study of the safety and efficacy of sertaconazole nitrate in the treatment of seborrheic dermatitis.

Journal: Journal of drugs in dermatology : JDD 20110801

Title: Efficacy and tolerability of sertaconazole nitrate 2% cream vs. miconazole in patients with cutaneous dermatophytosis.

Journal: Mycoses 20110501

Title: Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate.

Journal: The Journal of investigative dermatology 20101001

Title: Safety and efficacy of sertaconazole nitrate cream 2% in the treatment of tinea pedis interdigitalis: a subgroup analysis.

Journal: Cutis 20100201

Title: Sertaconazole 2% cream vs. miconazole 2% cream for cutaneous mycoses: a double-blind clinical trial.

Journal: Clinical and experimental dermatology 20091201

Title: A validated LC-MS/MS method for determination of sertaconazole nitrate in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091201

Title: What is your diagnosis? Tinea nigra.

Journal: Cutis 20091201

Title: Observational evaluation of sertaconazole nitrate cream 2% in the treatment of pruritus related to tinea pedis.

Journal: Cutis 20091101

Title: Safe and effective treatment of seborrheic dermatitis.

Journal: Cutis 20090601

Title: Sertaconazole nitrate cream 2% for the treatment of tinea pedis.

Journal: Cutis 20090501

Title: Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology.

Journal: Drugs 20090101

Title: Widespread, chronic, and fluconazole-resistant Trichophyton rubrum infection in an immunocompetent patient.

Journal: Mycoses 20081101

Title: In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents.

Journal: Journal of chemotherapy (Florence, Italy) 20080801

Title: Comprehensive management of patients with superficial fungal infections: the role of sertaconazole nitrate.

Journal: Cutis 20080601

Title: Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway.

Journal: The Journal of investigative dermatology 20080201

Title: Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis.

Journal: American journal of clinical dermatology 20070101

Title: Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections.

Journal: Diagnostic microbiology and infectious disease 20061001

Title: The safety and efficacy of sertaconazole nitrate cream 2% for tinea pedis.

Journal: Cutis 20061001

Title: Anti-inflammatory and anti-itch activity of sertaconazole nitrate.

Journal: Archives of dermatological research 20060901

Title: Sertaconazole/hydroxypropyl-beta-cyclodextrin complexation: isothermal titration calorimetry and solubility approaches.

Journal: Journal of pharmaceutical sciences 20060801

Title: Single-dose sertaconazole vaginal tablet treatment of vulvovaginal candidiasis.

Journal: Journal of the Chinese Medical Association : JCMA 20060601

Title: Nail penetration of sertaconazole with a sertaconazole-containing nail patch formulation.

Journal: American journal of clinical dermatology 20060101

Title: Drug solubilization and delivery from cyclodextrin-Pluronic aggregates.

Journal: Journal of nanoscience and nanotechnology 20060101

Title: Sertaconazole: updated review of a topical antifungal agent.

Journal: Expert review of anti-infective therapy 20050601

Title: Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration.

Journal: Arzneimittel-Forschung 20050101

Title: In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis.

Journal: Chemotherapy 20041201

Title: Topical sertaconazole (ertaczo)--another azole for tinea pedis.

Journal: The Medical letter on drugs and therapeutics 20040621

Title: In vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates.

Journal: Journal of chemotherapy (Florence, Italy) 20031201

Title: In vitro activity of sertaconazole against dermatophyte isolates with reduced fluconazole susceptibility.

Journal: Chemotherapy 20030901

Title: Effect of cyclodextrins on the solubility and antimycotic activity of sertaconazole: experimental and computational studies.

Journal: Journal of pharmaceutical sciences 20021101

Title: Sertaconazole: in-vitro antifungal activity against vaginal and other superficial yeast isolates.

Journal: Journal of chemotherapy (Florence, Italy) 20011001

Title: In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates.

Journal: Methods and findings in experimental and clinical pharmacology 20010301

Title: Comparative study of antifungal activity of sertaconazole, terbinafine, and bifonazole against clinical isolates of Candida spp., Cryptococcus neoformans and dermatophytes.

Journal: Chemotherapy 19970101

Title: Antifungal activity of sertaconazole in vitro against clinical isolates of Candida spp.

Journal: Chemotherapy 19960101

Title: In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp.

Journal: The Journal of antimicrobial chemotherapy 19951001

Title: In vitro activity of sertaconazole.

Journal: Arzneimittel-Forschung 19920501

Title: In vitro antifungal activity of sertaconazole.

Journal: Arzneimittel-Forschung 19920501

Title: In vitro comparative study of the fungistatic and fungicidal activity of sertaconazole and other antifungals against Candida albicans.

Journal: Arzneimittel-Forschung 19920501

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Tags:99592-32-2 Molecular Formula|99592-32-2 MDL|99592-32-2 SMILES|99592-32-2 1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole