66611-26-5,MFCD28157318
Catalog No.:AA00FB88

66611-26-5 | 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

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Purity
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Price(USD)
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5mg
95%
1 week  
$122.00   $85.00
- +
10mg
95%
1 week  
$155.00   $108.00
- +
50mg
95%
1 week  
$373.00   $261.00
- +
100mg
95%
1 week  
$528.00   $370.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FB88
Chemical Name:
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
CAS Number:
66611-26-5
Molecular Formula:
C14H16N2O
Molecular Weight:
228.2896
MDL Number:
MFCD28157318
SMILES:
COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
303  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.8  

Literature

Title: Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.

Journal: Biological psychiatry 20111201

Title: Serotonin receptors in rat jugular vein: presence and involvement in the contraction.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.

Journal: Biological psychiatry 20090301

Title: Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation.

Journal: PloS one 20090101

Title: Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.

Journal: European journal of pharmacology 20060710

Title: 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.

Journal: Bioorganic & medicinal chemistry letters 20051001

Title: Postsynaptic 5-HT1B receptors modulate electroshock-induced generalised seizures in rats.

Journal: British journal of pharmacology 20050301

Title: Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior.

Journal: Pharmacology, biochemistry, and behavior 20050201

Title: Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination.

Journal: Behavioural pharmacology 20041201

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040801

Title: Enkephalin contributes to the locomotor stimulating effects of 3,4-methylenedioxy-N-methylamphetamine.

Journal: The European journal of neuroscience 20030701

Title: Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Journal: Journal of neurochemistry 20011101

Title: Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401

Title: RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors.

Journal: Behavioural pharmacology 19990301

Title: Serotonin1B receptor stimulation enhances cocaine reinforcement.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19981201

Title: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.

Journal: European journal of pharmacology 19980821

Title: The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

Journal: European journal of pharmacology 19970501

Title: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

Journal: Journal of neurochemistry 19960101

Title: Cloning and characterisation of the human 5-HT5A serotonin receptor.

Journal: FEBS letters 19941205

Title: Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.

Journal: Molecular pharmacology 19930801

Title: Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.

Journal: Molecular pharmacology 19930301

Title: Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

Journal: Molecular pharmacology 19930301

Title: Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19920401

Title: Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

Journal: Molecular pharmacology 19910801

Title: The effect of serotonergic agents on haloperidol-induced catalepsy.

Journal: Life sciences 19900101

Title: Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4.

Title: Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16.

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SDS
Tags:66611-26-5 Molecular Formula|66611-26-5 MDL|66611-26-5 SMILES|66611-26-5 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Catalog No.: AA00FB88
66611-26-5,MFCD28157318
66611-26-5 | 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Pack Size: 5mg
Purity: 95%
1 week
$122.00 $85.00
Pack Size: 10mg
Purity: 95%
1 week
$155.00 $108.00
Pack Size: 50mg
Purity: 95%
1 week
$373.00 $261.00
Pack Size: 100mg
Purity: 95%
1 week
$528.00 $370.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FB88
Chemical Name: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
CAS Number: 66611-26-5
Molecular Formula: C14H16N2O
Molecular Weight: 228.2896
MDL Number: MFCD28157318
SMILES: COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1
Properties
Form: Solid  
Complexity: 303  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.8  
Literature fold

Title: Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.

Journal: Biological psychiatry20111201

Title: Serotonin receptors in rat jugular vein: presence and involvement in the contraction.

Journal: The Journal of pharmacology and experimental therapeutics20100701

Title: Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.

Journal: Biological psychiatry20090301

Title: Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation.

Journal: PloS one20090101

Title: Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.

Journal: European journal of pharmacology20060710

Title: 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.

Journal: Bioorganic & medicinal chemistry letters20051001

Title: Postsynaptic 5-HT1B receptors modulate electroshock-induced generalised seizures in rats.

Journal: British journal of pharmacology20050301

Title: Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior.

Journal: Pharmacology, biochemistry, and behavior20050201

Title: Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination.

Journal: Behavioural pharmacology20041201

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20040801

Title: Enkephalin contributes to the locomotor stimulating effects of 3,4-methylenedioxy-N-methylamphetamine.

Journal: The European journal of neuroscience20030701

Title: Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats.

Journal: Pharmacology, biochemistry, and behavior20020401

Title: Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Journal: Pharmacology, biochemistry, and behavior20020401

Title: Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.

Journal: Pharmacology, biochemistry, and behavior20020401

Title: An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour.

Journal: Pharmacology, biochemistry, and behavior20020401

Title: Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Journal: Journal of neurochemistry20011101

Title: Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20010401

Title: RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors.

Journal: Behavioural pharmacology19990301

Title: Serotonin1B receptor stimulation enhances cocaine reinforcement.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience19981201

Title: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.

Journal: European journal of pharmacology19980821

Title: The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

Journal: European journal of pharmacology19970501

Title: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

Journal: Journal of neurochemistry19960101

Title: Cloning and characterisation of the human 5-HT5A serotonin receptor.

Journal: FEBS letters19941205

Title: Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.

Journal: Molecular pharmacology19930801

Title: Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.

Journal: Molecular pharmacology19930301

Title: Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

Journal: Molecular pharmacology19930301

Title: Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

Journal: Proceedings of the National Academy of Sciences of the United States of America19920401

Title: Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

Journal: Molecular pharmacology19910801

Title: The effect of serotonergic agents on haloperidol-induced catalepsy.

Journal: Life sciences19900101

Title: Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4.

Title: Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16.

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