Home Other Building Blocks 666260-75-9
666260-75-9,MFCD11045840
Catalog No.:AA00FBG2

666260-75-9 | GW 842166X

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$32.00   $22.00
- +
5mg
≥98%
in stock  
$136.00   $95.00
- +
10mg
≥98%
in stock  
$240.00   $168.00
- +
25mg
≥98%
in stock  
$456.00   $319.00
- +
50mg
98%
in stock  
$804.00   $563.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBG2
Chemical Name:
GW 842166X
CAS Number:
666260-75-9
Molecular Formula:
C18H17Cl2F3N4O2
Molecular Weight:
449.2544
MDL Number:
MFCD11045840
SMILES:
Clc1cc(cc(c1)Cl)Nc1ncc(c(n1)C(F)(F)F)C(=O)NCC1CCOCC1
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
552  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.1  

Literature

Title: The endocannabinoid system: an overview.

Journal: Frontiers in behavioral neuroscience 20120101

Title: Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.

Journal: Journal of medicinal chemistry 20111027

Title: A randomized, controlled study to investigate the analgesic efficacy of single doses of the cannabinoid receptor-2 agonist GW842166, ibuprofen or placebo in patients with acute pain following third molar tooth extraction.

Journal: The Clinical journal of pain 20111001

Title: Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

Journal: Journal of medicinal chemistry 20091008

Title: Morpholine containing CB2 selective agonists.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.

Journal: Bioorganic & medicinal chemistry letters 20090101

Title: Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.

Journal: Bioorganic & medicinal chemistry 20080201

Title: Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

Journal: Journal of medicinal chemistry 20070531

Title: Giblin GM, et al. Discovery of 2-[(2,4-dichlorophenyl)amino-N-[(tetrahydro- 2H-pyran-4-yl)methyl-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600.

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