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6686-70-0,MFCD01736100
Catalog No.:AA00FEAM

6686-70-0 | DESTRUXIN A

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1mg
≥96%
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$766.00   $536.00
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5mg
≥96%
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$2,870.00   $2,009.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FEAM
Chemical Name:
DESTRUXIN A
CAS Number:
6686-70-0
Molecular Formula:
C29H47N5O7
Molecular Weight:
577.7128
MDL Number:
MFCD01736100
SMILES:
C=CC[C@H]1OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@@H](N(C(=O)[C@@H](NC(=O)[C@H]2N(C1=O)CCC2)[C@H](CC)C)C)C(C)C
Properties
Computed Properties
 
Complexity:
1020  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.3  

Literature

Title: Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles.

Journal: Toxicon : official journal of the International Society on Toxinology 20101101

Title: Effects of the cyclopeptide mycotoxin destruxin A on the Malpighian tubules of Rhodnius prolixus (Stål).

Journal: Toxicon : official journal of the International Society on Toxinology 20100601

Title: Formation of exudate droplets by Metarhizium anisopliae and the presence of destruxins.

Journal: Mycologia 20100101

Title: Destruxin production of Metarhizium anisopliae under carbon and nitrogen exhaustion.

Journal: Journal of basic microbiology 20090801

Title: Oxidative stress induced by destruxin from Metarhizium anisopliae (Metch.) involves changes in glutathione and ascorbate metabolism and instigates ultrastructural changes in the salivary glands of Spodoptera litura (Fab.) larvae.

Journal: Toxicon : official journal of the International Society on Toxinology 20080601

Title: Concurrence of losing a chromosome and the ability to produce destruxins in a mutant of Metarhizium anisopliae.

Journal: FEMS microbiology letters 20030926

Title: An investigation of the ionophoric characteristics of destruxin A.

Journal: Archives of biochemistry and biophysics 20020901

Title: Synthesis and biological evaluation of destruxin A and related analogs.

Journal: The journal of peptide research : official journal of the American Peptide Society 20010701

Title: Effects of efrapeptin and destruxin, metabolites of entomogenous fungi, on the hydrolytic activity of a vacuolar type ATPase identified on the brush border membrane vesicles of Galleria mellonella midgut and on plant membrane bound hydrolytic enzymes.

Journal: Biochimica et biophysica acta 20010209

Title: Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170.

Title: Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77.

Title: Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71.

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Tags:6686-70-0 Molecular Formula|6686-70-0 MDL|6686-70-0 SMILES|6686-70-0 DESTRUXIN A