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669089-53-6,MFCD09970999
Catalog No.:AA01E4XH

669089-53-6 | Urantide

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E4XH
Chemical Name:
Urantide
CAS Number:
669089-53-6
Molecular Formula:
C51H66N10O12S2
Molecular Weight:
1075.2595
MDL Number:
MFCD09970999
SMILES:
NCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)N)C(SSC[C@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)O)C(C)C)(C)C)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
1990  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
75  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
13  
Rotatable Bond Count:
17  
XLogP3:
-2.7  

Literature

Title: Urotensin II protects ischemic reperfusion injury of hearts through ROS and antioxidant pathway.

Journal: Peptides 20120801

Title: In vitro siRNA-mediated knockdown of the UT receptor: implications of density on the efficacy of a range of UT ligands.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120601

Title: Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphtidylinositol 3'-kinase - Akt pathway.

Journal: Canadian journal of physiology and pharmacology 20120501

Title: Effects of urotensin II on functional activity of late endothelial progenitor cells.

Journal: Peptides 20120101

Title: Urantide alleviates monocrotaline induced pulmonary arterial hypertension in Wistar rats.

Journal: Pulmonary pharmacology & therapeutics 20110801

Title: The interaction between human urotensin II and vasodilator agents in human internal mammary artery with possible clinical implications.

Journal: The Annals of thoracic surgery 20110801

Title: Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats.

Journal: American journal of physiology. Heart and circulatory physiology 20101201

Title: Urotensin II evokes neurotransmitter release from rat cerebrocortical slices.

Journal: Neuroscience letters 20080808

Title: Structure-activity relationships of urotensin II and URP.

Journal: Peptides 20080501

Title: Evidence for endogenous urotensin-II as an inhibitor of insulin secretion. Study in the perfused rat pancreas.

Journal: Peptides 20080501

Title: Hemodynamic-independent anti-natriuretic effect of urotensin II in spontaneously hypertensive rats.

Journal: Peptides 20080501

Title: [Protective effect of urantide against myocardial ischemia injury].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080201

Title: The involvement of transforming growth factor-beta1 secretion in urotensin II-induced collagen synthesis in neonatal cardiac fibroblasts.

Journal: Regulatory peptides 20070405

Title: Urotensin-II receptor ligands. From agonist to antagonist activity.

Journal: Journal of medicinal chemistry 20051117

Title: [Development of therapeutic agents related to urotensin II].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040901

Title: Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.

Journal: British journal of pharmacology 20031201

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