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67219-55-0,MFCD00010114
Catalog No.:AA005Q0V

67219-55-0 | N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

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1g
99% HPLC
in stock  
$14.00   $10.00
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100g
≥ 99% (HPLC)
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$962.00   $674.00
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250g
≥ 99% (HPLC)
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$2,244.00   $1,571.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005Q0V
Chemical Name:
N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
CAS Number:
67219-55-0
Molecular Formula:
C37H35N3O7
Molecular Weight:
633.6897
MDL Number:
MFCD00010114
SMILES:
COc1ccc(cc1)C(c1ccc(cc1)OC)(c1ccccc1)OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(nc1=O)NC(=O)c1ccccc1
Properties
Properties
 
BP:
668.71°C (rough estimate)  
Form:
Solid  
MP:
119 °C  
Refractive Index:
58 ° (C=1, MeOH)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
1080  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
11  
XLogP3:
5.3  

Downstream Synthesis Route

[1]Dorman,M.A.;Noble,S.A.;McBride,L.J.;Caruthers,M.H.[Tetrahedron,1984,vol.40,#1,p.95-102]

[1]Kumar,G.;Poonian,M.S.[JournalofOrganicChemistry,1984,vol.49,#25,p.4905-4912]

[2]Kore;Patil;Salunkhe[SyntheticCommunications,1993,vol.23,#18,p.2599-2603]

[3]Luo;Atrazheva;Fregeau;Gmeiner;Lown[CanadianJournalofChemistry,1994,vol.72,#6,p.1548-1555]

[4]Patil,SuchetaV.;Mane,RamchandraB.;Salunkhe,ManikraoM.[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1994,vol.33,#1,p.1-2]

[5]Nomura,Makoto;Shuto,Satoshi;Tanaka,Motohiro;Sasaki,Takuma;Mori,Shuichi;Shigeta,Shiro;Matsuda,Akira[JournalofMedicinalChemistry,1999,vol.42,#15,p.2901-2908]

[6]Radi,Marco;Spinosa,Raffaella;Parlato,MariaCristina;Corelli,Federico;Botta,Maurizio[Heterocycles,2006,vol.69,#1,p.151-166]

[7]Janczyk,Matthaeus;Appel,Bettina;Springstubbe,Danilo;Fritz,Hans-Joachim;Mueller,Sabine[OrganicandBiomolecularChemistry,2012,vol.10,#8,p.1510-1513]

[8]Baran,PhilS.;Eastgate,MartinD.;Knouse,KyleW.;Padial,NataliaM.;Rivas-Bascón,Nazaret;Schmidt,MichaelA.;Vantourout,JulienC.;Xu,Dongmin;Zheng,Bin[JournaloftheAmericanChemicalSociety,2020]

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-EP2921499,2015,A1Locationinpatent:Paragraph0524;0525;0526

[2]Kumar,G.;Poonian,M.S.[JournalofOrganicChemistry,1984,vol.49,#25,p.4905-4912]

[3]Marchan,Vicente;Cieslak,Jacek;Livengood,Victor;Beaucage,SergeL.[JournaloftheAmericanChemicalSociety,2004,vol.126,#31,p.9601-9610]

N-(1-{(2R,4S,5R)-5-Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl-4-trimethylsilanyloxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
  67219-55-0 

[1]Ti,G.S.;Gaffney,B.L.;Jones,R.A.[JournaloftheAmericanChemicalSociety,1982,vol.104,#5,p.1316-1319]

5666-12-6    67219-55-0   
C45H50N5O7P 

[1]Tetrahedron,1991,vol.47,p.2377-2388

[2]JournalofOrganicChemistry,1996,vol.61,p.4272-4281

Literature

Title: An improved synthesis of the dinucleotides pdCpA and pdCpdA.

Journal: Nucleosides, nucleotides & nucleic acids 20010301

Title: James W Gaynor, et al. Synthesis of the 3'-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage. Nat Protoc. 2007;2(12):3122-35.

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SDS
Tags:67219-55-0 Molecular Formula|67219-55-0 MDL|67219-55-0 SMILES|67219-55-0 N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine |Organic_Building_Blocks