Home Other Building Blocks 67416-61-9
67416-61-9,MFCD03788777
Catalog No.:AA005OEU

67416-61-9 | AKBA

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$33.00   $23.00
- +
10mg
95%
in stock  
$62.00   $44.00
- +
25mg
95%
in stock  
$124.00   $87.00
- +
100mg
95%
in stock  
$302.00   $212.00
- +
250mg
98%
in stock  
$384.00   $269.00
- +
1g
98%
in stock  
$1,105.00   $773.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005OEU
Chemical Name:
AKBA
CAS Number:
67416-61-9
Molecular Formula:
C32H48O5
Molecular Weight:
512.7205
MDL Number:
MFCD03788777
SMILES:
CC(=O)OC1CCC2(C(C1(C)C(=O)O)CCC1(C2C(=O)C=C2C1(C)CCC1(C2C(C)C(C)CC1)C)C)C
Properties
Properties
 
BP:
600.3°C at 760 mmHg  
Form:
Solid  
MP:
>250℃ (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
1060  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
7.2  

Literature

Title: Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.

Journal: Molecular and cellular biochemistry 20110801

Title: Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.

Journal: International journal of cancer 20110701

Title: Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata.

Journal: BMC microbiology 20110101

Title: Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.

Journal: PloS one 20110101

Title: A novel anticancer agent, retigeric acid B, displays proliferation inhibition, S phase arrest and apoptosis activation in human prostate cancer cells.

Journal: Chemico-biological interactions 20101205

Title: [Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20101101

Title: 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.

Journal: Bioorganic & medicinal chemistry 20100215

Title: 3-Acetyl-11-keto-beta-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity.

Journal: The Journal of pharmacy and pharmacology 20100201

Title: Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215

Title: Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080201

Title: Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.

Journal: Vascular pharmacology 20070501

Title: Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.

Journal: Pharmacology 20070101

Title: Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.

Journal: Molecular pharmacology 20060901

Title: Separation and quantification of terpenoids of Boswellia serrata Roxb. extract by planar chromatography techniques (TLC and AMD).

Journal: Journal of separation science 20060901

Title: Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060301

Title: Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.

Journal: Indian journal of experimental biology 20060201

Title: 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060101

Title: Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.

Journal: Methods and findings in experimental and clinical pharmacology 20050901

Title: Bioactive constituents from Boswellia papyrifera.

Journal: Journal of natural products 20050201

Title: Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2.

Journal: Advances in experimental medicine and biology 20020101

Title: Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.

Journal: Molecular pharmacology 20000701

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