Home Other Building Blocks 677338-12-4
677338-12-4,MFCD12910483
Catalog No.:AA00FAD8

677338-12-4 | PIK-90

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$28.00   $19.00
- +
5mg
≥98%
in stock  
$89.00   $62.00
- +
10mg
≥98%
in stock  
$123.00   $86.00
- +
25mg
98%
in stock  
$295.00   $207.00
- +
50mg
98%
in stock  
$375.00   $263.00
- +
100mg
98%
in stock  
$604.00   $423.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FAD8
Chemical Name:
PIK-90
CAS Number:
677338-12-4
Molecular Formula:
C18H17N5O3
Molecular Weight:
351.3593
MDL Number:
MFCD12910483
SMILES:
COc1c(OC)ccc2c1nc(NC(=O)c1cccnc1)n1c2=NCC1
Properties
Computed Properties
 
Complexity:
778  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.3  

Downstream Synthesis Route

[1]Scott,WilliamJ.;Hentemann,MartinF.;Rowley,R.Bruce;Bull,CathyO.;Jenkins,Susan;Bullion,AnnM.;Johnson,Jeffrey;Redman,Anikó;Robbins,ArthurH.;Esler,William;Fracasso,R.Paul;Garrison,Timothy;Hamilton,Mark;Michels,Martin;Wood,JillE.;Wilkie,DeanP.;Xiao,Hong;Levy,Joan;Stasik,Enrico;Liu,Ningshu;Schaefer,Martina;Brands,Michael;Lefranc,Julien[ChemMedChem,2016,p.1517-1530]

Literature

Title: Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.

Title: Niedermeier M, et al. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28;113(22):5549-57.

Title: Cheng CK, et al. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.

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SDS
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