Home Amines 68302-57-8
68302-57-8,MFCD00864790
Catalog No.:AA003317

68302-57-8 | 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid

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10mg
98%
in stock  
$6.00   $4.00
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50mg
98%
in stock  
$8.00   $6.00
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100mg
98%
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$11.00   $8.00
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1g
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$62.00   $44.00
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5g
98%
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$145.00   $102.00
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25g
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$271.00   $190.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003317
Chemical Name:
2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
CAS Number:
68302-57-8
Molecular Formula:
C16H14N2O4
Molecular Weight:
298.2934
MDL Number:
MFCD00864790
SMILES:
CC(c1ccc2c(c1)c(=O)c1c(o2)nc(c(c1)C(=O)O)N)C
Properties
Properties
 
BP:
570°C at 760 mmHg  
Form:
Solid  
MP:
>300 °C  
Solubility:
DMSO: soluble10mg/mL at warmed, clear  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
467  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
3.1  

Literature

Title: An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.

Journal: Nature medicine 20130301

Title: Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns.

Journal: Journal of neurochemistry 20121001

Title: Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study.

Journal: Oral surgery, oral medicine, oral pathology and oral radiology 20120501

Title: Development of a measure to assess effective listening and interactive communication skills in the delivery of children's rehabilitation services.

Journal: Disability and rehabilitation 20120101

Title: New Evidence-Based Treatment Approach in Behçet's Disease.

Journal: Pathology research international 20120101

Title: Clinical inquiry. What is the most effective way to treat recurrent canker sores?

Journal: The Journal of family practice 20111001

Title: Topical immunomodulators for management of oral mucosal conditions, a systematic review; Part II: miscellaneous agents.

Journal: Expert opinion on emerging drugs 20110301

Title: Nicolaus Copernicus: not only a great astronomer but also a physician.

Journal: Journal of nephrology 20110101

Title: Variable initial swing side and prolonged double limb support represent abnormalities of the first three steps of gait initiation in patients with Parkinson's disease with freezing of gait.

Journal: Frontiers in neurology 20110101

Title: Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor.

Journal: Biochemistry 20100323

Title: Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.

Journal: Biochemical pharmacology 20090615

Title: RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.

Journal: Journal of translational medicine 20090101

Title: A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial.

Journal: Trials 20090101

Title: PDE4 inhibitors: current status.

Journal: British journal of pharmacology 20081001

Title: [Local Treatment of stomatitis aphthosa].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20080901

Title: Treatment of allergic conjunctivitis with olopatadine hydrochloride eye drops.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20080901

Title: Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: an initial step in amlexanox-reversible non-classical release of FGF1.

Journal: Neurochemistry international 20080501

Title: Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract.

Journal: The journal of contemporary dental practice 20080301

Title: Effectiveness of two oral pastes for the treatment of recurrent aphthous stomatitis.

Journal: Oral diseases 20070901

Title: Mucocutaneous lesions of Behcet's disease.

Journal: Yonsei medical journal 20070831

Title: An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20061001

Title: Evidence for serum-deprivation-induced co-release of FGF-1 and S100A13 from astrocytes.

Journal: Neurochemistry international 20060801

Title: A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.

Journal: Journal of pharmacological sciences 20060801

Title: Voltage-dependent N-type Ca2+ channel activity regulates the interaction between FGF-1 and S100A13 for stress-induced non-vesicular release.

Journal: Cellular and molecular neurobiology 20060501

Title: The efficacy of amlexanox OraDisc on the prevention of recurrent minor aphthous ulceration.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20060201

Title: Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.

Journal: Mediators of inflammation 20060101

Title: Molecular mechanism of inhibition of nonclassical FGF-1 export.

Journal: Biochemistry 20051129

Title: A comparative study of the efficacy of Aphtheal in the management of recurrent minor aphthous ulceration.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20050801

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Amlexanox for the treatment of recurrent aphthous ulcers.

Journal: Clinical drug investigation 20050101

Title: Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox.

Journal: The Biochemical journal 20030901

Title: Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein.

Journal: Biochemical and biophysical research communications 20020412

Title: Selecting topical and systemic agents for recurrent aphthous stomatitis.

Journal: Cutis 20010901

Title: The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock.

Journal: The Journal of biological chemistry 20010216

Title: Treatment strategies for recurrent oral aphthous ulcers.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010101

Title: The comparative release of FGF1 by hypoxia and temperature stress.

Journal: Growth factors (Chur, Switzerland) 20010101

Title: Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase.

Journal: International archives of allergy and applied immunology 19870101

Title: Reilly SM, et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21.

Title: Bell, J. AmLexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig, 2005. 25(9): p. 555-66.

Title: Zhang Y, et al. AmLexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss. Sci Rep. 2015 Sep 4;5:13575.

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Tags:68302-57-8 Molecular Formula|68302-57-8 MDL|68302-57-8 SMILES|68302-57-8 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid |Heterocyclic_Building_Blocks