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6859-01-4,MFCD22124712
Catalog No.:AA00IKIO

6859-01-4 | Isorhynchophylline

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5mg
≥95%
in stock  
$82.00   $57.00
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10mg
≥95%
in stock  
$128.00   $89.00
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25mg
≥95%
in stock  
$256.00   $179.00
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50mg
≥95%
in stock  
$472.00   $330.00
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500mg
98% by HPLC
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$3,179.00   $2,226.00
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1000mg
98% by HPLC
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$5,049.00   $3,534.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IKIO
Chemical Name:
Isorhynchophylline
CAS Number:
6859-01-4
Molecular Formula:
C22H28N2O4
Molecular Weight:
384.4687
MDL Number:
MFCD22124712
SMILES:
CO/C=C(\[C@H]1C[C@@H]2N(C[C@@H]1CC)CC[C@]12C(=O)Nc2c1cccc2)/C(=O)OC
Properties
Computed Properties
 
Complexity:
663  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.3  

Literature

Title: Rhynchophylline prevents cardiac dysfunction and improves survival in lipopolysaccharide-challenged mice via suppressing macrophage I-κBα phosphorylation.

Journal: International immunopharmacology 20121101

Title: Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-κB signaling pathways in primary microglia.

Journal: Phytotherapy research : PTR 20121001

Title: Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases.

Journal: Fitoterapia 20120601

Title: Protective effect of isorhynchophylline against β-amyloid-induced neurotoxicity in PC12 cells.

Journal: Cellular and molecular neurobiology 20120401

Title: Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

Journal: Autophagy 20120101

Title: Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.

Journal: Journal of natural products 20110128

Title: Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity.

Journal: Journal of ethnopharmacology 20101028

Title: Effect of rhynchophylline on central neurotransmitter levels in amphetamine-induced conditioned place preference rat brain.

Journal: Fitoterapia 20101001

Title: Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin O in vitro.

Journal: Veterinary microbiology 20100714

Title: Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat.

Journal: Archives of pharmacal research 20100401

Title: Metabolism and pharmacokinetics of rhynchophylline in rats.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Metabolism of isorhynchophylline in rats detected by LC-MS.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

Title: [Effect of major components of maijunan tablets on the transport of hydrochlorothiazide in Caco-2 cell monolayer model].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100101

Title: Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism.

Journal: International immunopharmacology 20091201

Title: [HPLC determination of rhynchophylline and isorhynchophylline in Anshen Yangxue oral liquid].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090701

Title: Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.

Journal: Journal of natural products 20090522

Title: Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats.

Journal: The American journal of Chinese medicine 20090101

Title: Effects of isorhynchophylline on angiotensin II-induced proliferation in rat vascular smooth muscle cells.

Journal: The Journal of pharmacy and pharmacology 20081201

Title: Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.

Journal: Journal of natural products 20080701

Title: General strategy for the syntheses of corynanthe, tacaman, and oxindole alkaloids.

Journal: The Journal of organic chemistry 20060818

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20051025

Title: Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.

Journal: European journal of pharmacology 20050711

Title: Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action.

Journal: Life sciences 20041203

Title: In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel).

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040201

Title: Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline.

Journal: Acta pharmacologica Sinica 20030201

Title: Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes.

Journal: European journal of pharmacology 20021122

Title: Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells.

Journal: Acta pharmacologica Sinica 20020501

Title: Yan-Fang Xian, et al. Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice. Neurochemistry International Volume 76, October 2014, Pages 42–49

Title: Guo H, et al. Isorhynchophylline protects against pulmonary arterial hypertension and suppresses PASMCs proliferation. Biochem Biophys Res Commun. 2014 Jul 18;450(1):729-34.

Title: LI Qiang, et al. Inhibitory effect of isorhynchophylline on cardiomyocyte hypertrophy induced by angiotensinⅡ. West China JOurnal of Pharmaceutical Sciences, 2013-05

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