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687-51-4,MFCD00238027
Catalog No.:AA006H98

687-51-4 | H-Leu-NH2

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1g
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$32.00   $23.00
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5g
95%
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$70.00   $49.00
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25g
95%
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$270.00   $189.00
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100g
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006H98
Chemical Name:
H-Leu-NH2
CAS Number:
687-51-4
Molecular Formula:
C6H14N2O
Molecular Weight:
130.1882
MDL Number:
MFCD00238027
SMILES:
N[C@H](C(=O)N)CC(C)C
Properties
Properties
 
BP:
250.9°C at 760 mmHg  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
101  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
0.1  

Upstream Synthesis Route

[1]Tetrahedron,1984,vol.40,#21,p.4425-4432

[1]Patent:US2017/57911,2017,A1,.Locationinpatent:Paragraph0060;0127;0129

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.4686,4689

[2]BioorganicandMedicinalChemistryLetters,2011,vol.21,#24,p.7355-7358

[3]JournalofMedicinalChemistry,2013,vol.56,#6,p.2374-2384

[4]Patent:US2017/183318,2017,A1,.Locationinpatent:Paragraph0178;1079

[1]Patent:US2006/223855,2006,A1,.Locationinpatent:Page/Pagecolumn138

[1]EuropeanJournalofMedicinalChemistry,1985,vol.20,#6,p.509-512

[2]Chemistry-AnAsianJournal,2011,vol.6,#6,p.1321-1324

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1957,vol.79,p.4686,4689

[2]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.7355-7358

[3]JournalofMedicinalChemistry,2013,vol.56,p.2374-2384

[4]Patent:US2017/183318,2017,A1.Locationinpatent:Paragraph0178;1079

[1]CollectionofCzechoslovakChemicalCommunications,1982,vol.47,p.1000-1019

[2]OrganicandBiomolecularChemistry,2019,vol.17,p.5244-5248

[3]HelveticaChimicaActa,1955,vol.38,p.2036

[4]RussianChemicalBulletin,1997,vol.46,p.1936-1938

[5]BulletinoftheChemicalSocietyofJapan,1997,vol.70,p.3025-3029

[1]JournaloftheAmericanChemicalSociety,1961,vol.83,p.145-149

687-51-4    686-50-0   
L-Leu-Gly-L-Leu-NH2 

[1]AgriculturalandBiologicalChemistry,1987,vol.51,p.2657-2664

[2]AgriculturalandBiologicalChemistry,1987,vol.51,p.2657-2664

[1]JournalofOrganicChemistry,1997,vol.62,p.3488-3495

[2]JournaloftheAmericanChemicalSociety,1987,vol.109,p.3802-3804

[3]NatureChemistry,2013,vol.5,p.495-501

[4]JournaldeChimiePhysiqueetdePhysico-ChimieBiologique,1987,vol.84,p.1113-1118

[5]JournaloftheAmericanChemicalSociety,1994,vol.116,p.5009-5010

[6]JournaloftheChemicalSociety.PerkinTransactions2(2001),2001,p.1394-1399

Literature

Title: Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA).

Journal: Peptides 20120901

Title: Host-defense peptides in skin secretions of African clawed frogs (Xenopodinae, Pipidae).

Journal: General and comparative endocrinology 20120501

Title: Host-defense peptides from skin secretions of the tetraploid frogs Xenopus petersii and Xenopus pygmaeus, and the octoploid frog Xenopus lenduensis (Pipidae).

Journal: Peptides 20120101

Title: Rotational spectra and computational analysis of two conformers of leucinamide.

Journal: The journal of physical chemistry. A 20110901

Title: Genome duplications within the Xenopodinae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions.

Journal: Comparative biochemistry and physiology. Part D, Genomics & proteomics 20110601

Title: Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20101101

Title: Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae).

Journal: Peptides 20100601

Title: Design and synthesis of selective inhibitors of placental alkaline phosphatase.

Journal: Bioorganic & medicinal chemistry 20100115

Title: Marine drugs from sponge-microbe association--a review.

Journal: Marine drugs 20100101

Title: L-Leucinamide hydrogensquarate: spectroscopic and structural elucidation.

Journal: Amino acids 20091001

Title: HPLC Method for Determination of Enantiomeric Purity of a Novel Respiratory Fluoroquinolone: WCK 1152.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery.

Journal: ChemMedChem 20070601

Title: L: -Stereoselective amino acid amidase with broad substrate specificity from Brevundimonas diminuta: characterization of a new member of the leucine aminopeptidase family.

Journal: Applied microbiology and biotechnology 20060401

Title: Application of Fourier transform infrared spectroscopy for monitoring hydrolysis and synthesis reactions catalyzed by a recombinant amidase.

Journal: Analytical biochemistry 20051101

Title: Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040816

Title: Kinetics and mechanism of a reaction catalyzed by PST-01 protease from Pseudomonas aeruginosa PST-01.

Journal: Biotechnology and bioengineering 20040505

Title: First total synthesis of leucamide A.

Journal: The Journal of organic chemistry 20030221

Title: Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.

Journal: Biological chemistry 20030201

Title: Leucamide A: a new cytotoxic heptapeptide from the Australian sponge Leucetta microraphis.

Journal: The Journal of organic chemistry 20020712

Title: Chiral inversion of (R)-(-)-fenoprofen in guinea-pigs pretreated with clofibrate.

Journal: Veterinary research communications 20020601

Title: [Kinetics and mechanism of peptide synthesis in solution].

Journal: Bioorganicheskaia khimiia 20020101

Title: Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).

Journal: Biochimica et biophysica acta 20011126

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