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69049-74-7,MFCD00941388
Catalog No.:AA00FFJ7

69049-74-7 | Nedocromil sodium

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1mg
97%
in stock  
$9.00   $7.00
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50mg
97%
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$96.00   $68.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FFJ7
Chemical Name:
Nedocromil sodium
CAS Number:
69049-74-7
Molecular Formula:
C19H15NNa2O7
Molecular Weight:
415.3044
MDL Number:
MFCD00941388
SMILES:
CCCc1c2oc(cc(=O)c2cc2c1n(CC)c(cc2=O)C(=O)[O-])C(=O)[O-].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
742  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Rotatable Bond Count:
3  

Downstream Synthesis Route

[1]Cairns,Hugh;Cox,David;Gould,KenJ.;Ingall,AnthonyH.;Suschitzky,JohnL.[JournalofMedicinalChemistry,1985,vol.28,#12,p.1832-1842]

69049-74-7   
C19H13(2)H2NO7(2-)*2Na(1+) 

[1]Hesk;Jones;Lockley[JournalofPharmaceuticalSciences,1991,vol.80,#9,p.887-890]

69049-74-7   
C19H13(3)H2NO7(2-)*2Na(1+) 

[1]Hesk;Jones;Lockley[JournalofPharmaceuticalSciences,1991,vol.80,#9,p.887-890]

69049-74-7   
9-Ethyl-4-hydroxy-6-oxo-10-propyl-3,4,6,9-tetrahydro-2H-pyrano<3,2-g>chinolin-2,8-dicarbonsaeure 

[1]Hermening;Hoffmann[ArchivderPharmazie,1995,vol.328,#6,p.527-529]

69049-74-7   
nedocromilcalciumpentahydrate 

[1]Zhu,Haijian;Halfen,JasonA.;YoungJr.,VictorG.;Padden,BrianE.;Munson,EricJ.;Menon,Vijeev;Grant,DavidJ.W.[JournalofPharmaceuticalSciences,1997,vol.86,#12,p.1439-1447]

Literature

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Journal: The New England journal of medicine 20120906

Title: Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D.

Journal: The Journal of allergy and clinical immunology 20120701

Title: Analysis of nedocromil sodium using ESI-QTOF.

Journal: Journal of mass spectrometry : JMS 20120701

Title: Prevention of adverse cardiac remodeling to volume overload in female rats is the result of an estrogen-altered mast cell phenotype.

Journal: American journal of physiology. Heart and circulatory physiology 20120201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Predictors of symptoms are different from predictors of severe exacerbations from asthma in children.

Journal: Chest 20110701

Title: An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse.

Journal: Laboratory investigation; a journal of technical methods and pathology 20110101

Title: Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100901

Title: Risk of cataracts in the Childhood Asthma Management Program Cohort.

Journal: The Journal of allergy and clinical immunology 20100801

Title: Polymorphisms of chitinases are not associated with asthma.

Journal: The Journal of allergy and clinical immunology 20100301

Title: Predictors of remitting, periodic, and persistent childhood asthma.

Journal: The Journal of allergy and clinical immunology 20100201

Title: Serum beta2-microglobulin concentration as a novel marker to distinguish levels of risk in acute heart failure patients.

Journal: Journal of cardiology 20100101

Title: Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma.

Journal: The Cochrane database of systematic reviews 20100101

Title: The effect of asthma therapeutics on signalling and transcriptional regulation of airway smooth muscle function.

Journal: Pulmonary pharmacology & therapeutics 20091001

Title: Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.

Journal: Biochemical pharmacology 20090615

Title: Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness.

Journal: The European respiratory journal 20090601

Title: Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart.

Journal: Hypertension (Dallas, Tex. : 1979) 20090601

Title: Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents.

Journal: The Journal of pediatrics 20090501

Title: Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.

Journal: American journal of respiratory and critical care medicine 20090301

Title: Relationship between mast cells and the colitis with relapse induced by trinitrobenzesulphonic acid in Wistar rats.

Journal: Mediators of inflammation 20090101

Title: Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma.

Journal: Respiratory research 20090101

Title: Recent-onset bronchial asthma as a manifestation of systemic mastocytosis.

Journal: Journal of investigational allergology & clinical immunology 20090101

Title: Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program.

Journal: The Journal of allergy and clinical immunology 20081101

Title: Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history.

Journal: American journal of respiratory and critical care medicine 20080815

Title: Identifying the components of asthma health status in children with mild to moderate asthma.

Journal: The Journal of allergy and clinical immunology 20080501

Title: The comparison of diphenhydramine HCl and Nedocromil sodium in prevention of abdominal postoperative adhesion formation in rat models: an experimental study.

Journal: International journal of surgery (London, England) 20071201

Title: Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20071101

Title: Anti-inflammatory pharmacotherapy for wheezing in preschool children.

Journal: Pediatric pulmonology 20070501

Title: The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance.

Journal: Journal of pharmaceutical sciences 20070501

Title: Susceptibility of salmonid alphavirus to a range of chemical disinfectants.

Journal: Journal of fish diseases 20070501

Title: Childhood Asthma Management Program: lessons learned.

Journal: The Journal of allergy and clinical immunology 20070101

Title: AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.

Journal: European journal of clinical investigation 20061201

Title: Rat cardiac mast cell maturation and differentiation following acute ventricular volume overload.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061001

Title: Forced expiratory volume in 1 second percentage improves the classification of severity among children with asthma.

Journal: Pediatrics 20060801

Title: Protective effects of nedocromil sodium and sodium cromoglycate on gastroduodenal ulcers: a comparative study in rats.

Journal: Inflammopharmacology 20060801

Title: Nedocromil sodium for chronic asthma in children.

Journal: The Cochrane database of systematic reviews 20060719

Title: Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060501

Title: Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects.

Journal: Respirology (Carlton, Vic.) 20050901

Title: Pharmacologic inhibition of mast cell degranulation prevents left ventricular remodeling induced by chronic volume overload in rats.

Journal: Journal of cardiac failure 20050901

Title: The challenge of mild persistent asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050501

Title: Asthma controller therapy during pregnancy.

Journal: American journal of obstetrics and gynecology 20050201

Title: [Strategies for the prevention and treatment of allergies in children and adolescents].

Journal: MMW Fortschritte der Medizin 20041209

Title: Clinical inquiries. Is nedocromil effective in preventing asthmatic attacks in patients with asthma?

Journal: The Journal of family practice 20041101

Title: Safety and application of induced sputum analysis in childhood asthma.

Journal: The Journal of allergy and clinical immunology 20040901

Title: Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20040801

Title: Asthma and other wheezing disorders in infants and children.

Journal: Clinical evidence 20040601

Title: Sensitivity analysis of longitudinal normal data with drop-outs.

Journal: Statistics in medicine 20040415

Title: Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040301

Title: Evaluation of preoperative and postoperative prophylactic regimens for prevention and treatment of diffuse lamellar keratitis.

Journal: Journal of cataract and refractive surgery 20040101

Title: Inhaled cromones for prolonged non-specific cough in children.

Journal: The Cochrane database of systematic reviews 20040101

Title: Single-dose agents in the prevention of exercise-induced asthma: a descriptive review.

Journal: Treatments in respiratory medicine 20040101

Title: Immune response to hepatitis B vaccine in asthmatic children.

Journal: Pediatric pulmonology 20031201

Title: Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial.

Journal: Allergy 20030801

Title: Minimizing attrition in a long-term clinical trial of pediatric asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030801

Title: Model-free treatment of the dehydration kinetics of nedocromil sodium trihydrate.

Journal: Journal of pharmaceutical sciences 20030701

Title: A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model.

Journal: Clinical therapeutics 20030701

Title: Long-term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma.

Journal: Pediatrics 20030601

Title: Supplementation of fexofenadine therapy with nedocromil sodium 2% ophthalmic solution to treat ocular symptoms of seasonal allergic conjunctivitis.

Journal: Clinical & experimental ophthalmology 20030601

Title: Asthma and other wheezing disorders of childhood.

Journal: Clinical evidence 20030601

Title: Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.

Journal: The Journal of pediatrics 20030501

Title: Corneal flap complications in refractive surgery: Part 2: postoperative treatments of diffuse lamellar keratitis in an experimental animal model.

Journal: Journal of cataract and refractive surgery 20030401

Title: A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.

Journal: Clinical therapeutics 20030401

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Arterial hypoxemia in exercising thoroughbreds is not affected by pre-exercise nedocromil sodium inhalation.

Journal: Respiratory physiology & neurobiology 20030303

Title: Treatment compliance, passive smoking, and asthma control: a three year cohort study.

Journal: Archives of disease in childhood 20030301

Title: Two mast cell stabilizers, pemirolast potassium 0.1% and nedocromil sodium 2%, in the treatment of seasonal allergic conjunctivitis: a comparative study.

Journal: Advances in therapy 20030101

Title: Antiasthmatic effects of nedocromil sodium.

Journal: Bratislavske lekarske listy 20030101

Title: [For the family physician allergy season is all year long. Strategies against running noses].

Journal: MMW Fortschritte der Medizin 20021107

Title: Effects of nedocromil and salbutamol on airway reactivity in children with asthma.

Journal: The European respiratory journal 20020901

Title: Floating a metered-dose inhaler is not an accurate measure of remaining medicine.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020501

Title: Solvation mechanisms of nedocromil sodium from activation energy and reaction enthalpy measurements of dehydration and dealcoholation.

Journal: Journal of pharmaceutical sciences 20020401

Title: Mast cells involvement in the inflammation and fibrosis development of the TNBS-induced rat model of colitis.

Journal: Scandinavian journal of gastroenterology 20020301

Title: [Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: [The effect of nedocromil sodium on levels of IL-4 and IgE in serum of children with bronchial asthma].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: [The effect of triamcinolone acetonide, montelukast, nedocromil sodium, formoterol on levels levels of sICAM-1, sIL-2R in serum and clinical course of asthma in children].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020201

Title: Crystal structure and thermal behavior of nedocromil nickel octahydrate.

Journal: International journal of pharmaceutics 20020131

Title: Mast cell dynamics and involvement in the development of peritoneal adhesions in the rat.

Journal: Life sciences 20020111

Title: Nedocromil sodium for preventing exercise-induced bronchoconstriction.

Journal: The Cochrane database of systematic reviews 20020101

Title: [Efficacy of low intensity laser irradiation and sodium nedocromil in the complex treatment of patients with bronchial asthma].

Journal: Terapevticheskii arkhiv 20020101

Title: Twice-daily and once-daily nedocromil sodium 2% ophthalmic solution for the treatment of seasonal allergic conjunctivitis.

Journal: Advances in therapy 20020101

Title: Nedocromil sodium ophthalmic solution 2% twice daily in patients with allergic conjunctivitis.

Journal: Advances in therapy 20020101

Title: Respiratory function changes in a wilderness multisport endurance competition: a prospective case study.

Journal: Wilderness & environmental medicine 20020101

Title: [IL-10 serum levels in children with moderate asthma].

Journal: Pneumonologia i alergologia polska 20020101

Title: [Nedocromil sodium--the influence on allergic inflammation].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20020101

Title: Comparison of emedastine 0.05% or nedocromil sodium 2% eye drops and placebo in controlling local reactions in subjects with allergic conjunctivitis.

Journal: European journal of ophthalmology 20020101

Title: Allergen challenge and deposition of nedocromil sodium in asthma.

Journal: Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 20020101

Title: Inhaled nedocromil sodium for persistent cough in children.

Journal: The Medical journal of Malaysia 20011201

Title: Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms.

Journal: The Journal of allergy and clinical immunology 20010901

Title: Budesonide but not nedocromil sodium reduces exhaled nitric oxide levels in asthmatic children.

Journal: Respiratory medicine 20010901

Title: Asthma symptoms, morbidity, and antiinflammatory use in inner-city children.

Journal: Pediatrics 20010801

Title: Interleukin-2 activates human peripheral blood eosinophils.

Journal: Cellular immunology 20010615

Title: Asthma in the hospitalized obstetrical patient.

Journal: Clinical reviews in allergy & immunology 20010601

Title: Double-blind, randomized, placebo-controlled trial of effect of nedocromil sodium on clinical and inflammatory parameters of asthma in children allergic to dust mite.

Journal: Allergy 20010601

Title: Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells.

Journal: Respiratory medicine 20010501

Title: Fog-induced respiratory responses are attenuated by nedocromil sodium in humans.

Journal: American journal of respiratory and critical care medicine 20010401

Title: Dehydration behavior of nedocromil magnesium pentahydrate.

Journal: International journal of pharmaceutics 20010314

Title: Exhaled nitric oxide in seasonal allergic rhinitis: influence of pollen season and therapy.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010301

Title: [Anti-allergy therapy in children].

Journal: Allergie et immunologie 20010301

Title: Nedocromil sodium inhibits histamine-induced itch and flare in human skin.

Journal: British journal of pharmacology 20010201

Title: The formulation of powder inhalation systems containing a high mass of nedocromil sodium trihydrate.

Journal: Journal of pharmaceutical sciences 20010201

Title: Is budesonide or nedocromil superior in the long-term management of mild to moderate asthma in children?

Journal: The Journal of family practice 20010101

Title: Nedocromil sodium versus sodium cromoglycate in treatment of exercise-induced bronchoconstriction: a systematic review.

Journal: The European respiratory journal 20010101

Title: [Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].

Journal: Terapevticheskii arkhiv 20010101

Title: Nedocromil sodium in golfers with seasonal allergic conjunctivitis.

Journal: Advances in therapy 20010101

Title: Inhibition of GM-CSF secretion by topical corticosteroids and nedocromil sodium. A comparison study using nasal polyp epithelial cells.

Journal: Respiratory medicine 20000501

Title: Risk of non-fatal cardiac failure and ischaemic heart disease with long acting beta 2 agonists.

Journal: Thorax 19980701

Title: Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19971201

Title: Effects of nedocromil sodium and WEB 2086 on chemoattractant-stimulated neutrophil migration through cellular and noncellular barriers.

Journal: Annals of allergy 19921001

Title: Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.

Journal: International archives of allergy and applied immunology 19900101

Title: Nedocromil sodium: a new drug for the management of bronchial asthma.

Journal: Thorax 19841101

Title: Wells E, et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mastcells. J Immunol. 1986 Dec 15;137(12):3941-5.

Title: Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8(3):e60827.

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