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69049-73-6,MFCD00864606
Catalog No.:AA0035AT

69049-73-6 | NEDOCROMIL

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Purity
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5mg
98%
1 week  
$177.00   $124.00
- +
10mg
98%
1 week  
$257.00   $180.00
- +
25mg
98%
1 week  
$463.00   $324.00
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50mg
98%
1 week  
$717.00   $502.00
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100mg
98%
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$1,098.00   $769.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0035AT
Chemical Name:
NEDOCROMIL
CAS Number:
69049-73-6
Molecular Formula:
C19H17NO7
Molecular Weight:
371.3408
MDL Number:
MFCD00864606
SMILES:
CCCc1c2oc(cc(=O)c2cc2c1n(CC)c(cc2=O)C(=O)O)C(=O)O
Properties
Properties
 
BP:
645.5°C at 760 mmHg  
Form:
Solid  
MP:
299 °C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
753  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route
CASUnavailable 
  69049-73-6   
CASUnavailable 

[1]CurrentPatentAssignee:SANOFI-US4849427,1989,A

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Title: AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil.

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Title: Nedocromil sodium for chronic asthma in children.

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Title: Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis.

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Title: Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects.

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Title: Pharmacologic inhibition of mast cell degranulation prevents left ventricular remodeling induced by chronic volume overload in rats.

Journal: Journal of cardiac failure 20050901

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Journal: Environmental health perspectives 20050401

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Title: Asthma controller therapy during pregnancy.

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Title: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis.

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Journal: Respiratory research 20050101

Title: As-needed inhaled beta2-adrenoceptor agonists in moderate-to-severe asthma: current recommendations.

Journal: Treatments in respiratory medicine 20050101

Title: Cough: are children really different to adults?

Journal: Cough (London, England) 20050101

Title: The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline.

Journal: Respiratory research 20050101

Title: Role of leukotriene receptor antagonists in the treatment of exercise-induced bronchoconstriction: a review.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20050101

Title: Asthma and therapeutics: inhaled corticosteroids, corticosteroid osteoporosis, and the risk of fracture in chronic asthma.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20050101

Title: Asthma and therapeutics: recombinant therapies in asthma.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20050101

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Journal: MMW Fortschritte der Medizin 20041209

Title: Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation, and myocardial remodeling in rats.

Journal: American journal of physiology. Heart and circulatory physiology 20041101

Title: Clinical inquiries. Is nedocromil effective in preventing asthmatic attacks in patients with asthma?

Journal: The Journal of family practice 20041101

Title: Safety and application of induced sputum analysis in childhood asthma.

Journal: The Journal of allergy and clinical immunology 20040901

Title: Progression of asthma measured by lung function in the childhood asthma management program.

Journal: American journal of respiratory and critical care medicine 20040801

Title: Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20040801

Title: Evidence-based asthma management.

Journal: Respiratory care 20040701

Title: Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma.

Journal: Pediatrics 20040601

Title: Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20040601

Title: Asthma and other wheezing disorders in infants and children.

Journal: Clinical evidence 20040601

Title: Sensitivity analysis of longitudinal normal data with drop-outs.

Journal: Statistics in medicine 20040415

Title: Disodium cromoglycate suppresses the induction of cysteinyl leukotriene synthesis during granulocytic differentiation in HL-60 cells.

Journal: Respiratory medicine 20040301

Title: Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040301

Title: Evaluation of preoperative and postoperative prophylactic regimens for prevention and treatment of diffuse lamellar keratitis.

Journal: Journal of cataract and refractive surgery 20040101

Title: Bench-to-bedside review: beta2-Agonists and the acute respiratory distress syndrome.

Journal: Critical care (London, England) 20040101

Title: Inhaled cromones for prolonged non-specific cough in children.

Journal: The Cochrane database of systematic reviews 20040101

Title: Single-dose agents in the prevention of exercise-induced asthma: a descriptive review.

Journal: Treatments in respiratory medicine 20040101

Title: Severe acute respiratory syndrome, a pathological immune response to the new coronavirus--implications for understanding of pathogenesis, therapy, design of vaccines, and epidemiology.

Journal: Viral immunology 20040101

Title: Actual therapeutic management of allergic and hyperreactive nasal disorders.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20040101

Title: Immune response to hepatitis B vaccine in asthmatic children.

Journal: Pediatric pulmonology 20031201

Title: Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial.

Journal: Allergy 20030801

Title: Minimizing attrition in a long-term clinical trial of pediatric asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030801

Title: Model-free treatment of the dehydration kinetics of nedocromil sodium trihydrate.

Journal: Journal of pharmaceutical sciences 20030701

Title: A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model.

Journal: Clinical therapeutics 20030701

Title: Long-term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma.

Journal: Pediatrics 20030601

Title: Supplementation of fexofenadine therapy with nedocromil sodium 2% ophthalmic solution to treat ocular symptoms of seasonal allergic conjunctivitis.

Journal: Clinical & experimental ophthalmology 20030601

Title: Asthma and other wheezing disorders of childhood.

Journal: Clinical evidence 20030601

Title: Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.

Journal: The Journal of pediatrics 20030501

Title: Corneal flap complications in refractive surgery: Part 2: postoperative treatments of diffuse lamellar keratitis in an experimental animal model.

Journal: Journal of cataract and refractive surgery 20030401

Title: A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.

Journal: Clinical therapeutics 20030401

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Arterial hypoxemia in exercising thoroughbreds is not affected by pre-exercise nedocromil sodium inhalation.

Journal: Respiratory physiology & neurobiology 20030303

Title: Treatment compliance, passive smoking, and asthma control: a three year cohort study.

Journal: Archives of disease in childhood 20030301

Title: Limitations of maintenance therapy for viral respiratory infection-induced asthma.

Journal: The Journal of pediatrics 20030201

Title: A review of once-daily delivery of anti-asthmatic drugs in children.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20030201

Title: Two mast cell stabilizers, pemirolast potassium 0.1% and nedocromil sodium 2%, in the treatment of seasonal allergic conjunctivitis: a comparative study.

Journal: Advances in therapy 20030101

Title: Antiasthmatic effects of nedocromil sodium.

Journal: Bratislavske lekarske listy 20030101

Title: [For the family physician allergy season is all year long. Strategies against running noses].

Journal: MMW Fortschritte der Medizin 20021107

Title: Human ocular mast cells.

Journal: Current opinion in allergy and clinical immunology 20021001

Title: Effects of nedocromil and salbutamol on airway reactivity in children with asthma.

Journal: The European respiratory journal 20020901

Title: Nedocromil sodium and levocabastine.

Journal: Current allergy and asthma reports 20020701

Title: Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020701

Title: [Exhaled nitric oxide in healthy and asthmatic children].

Journal: Anales espanoles de pediatria 20020701

Title: Floating a metered-dose inhaler is not an accurate measure of remaining medicine.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020501

Title: Solvation mechanisms of nedocromil sodium from activation energy and reaction enthalpy measurements of dehydration and dealcoholation.

Journal: Journal of pharmaceutical sciences 20020401

Title: Mast cells involvement in the inflammation and fibrosis development of the TNBS-induced rat model of colitis.

Journal: Scandinavian journal of gastroenterology 20020301

Title: [Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: [The effect of nedocromil sodium on levels of IL-4 and IgE in serum of children with bronchial asthma].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020301

Title: Using case management to increase antiinflammatory medication use among a managed care population with asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20020201

Title: [The effect of triamcinolone acetonide, montelukast, nedocromil sodium, formoterol on levels levels of sICAM-1, sIL-2R in serum and clinical course of asthma in children].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020201

Title: Crystal structure and thermal behavior of nedocromil nickel octahydrate.

Journal: International journal of pharmaceutics 20020131

Title: Mast cell dynamics and involvement in the development of peritoneal adhesions in the rat.

Journal: Life sciences 20020111

Title: Nedocromil sodium for preventing exercise-induced bronchoconstriction.

Journal: The Cochrane database of systematic reviews 20020101

Title: Inhaled hyperosmolar agents for bronchiectasis.

Journal: The Cochrane database of systematic reviews 20020101

Title: Montelukast: a review of its therapeutic potential in asthma in children 2 to 14 years of age.

Journal: Paediatric drugs 20020101

Title: [Efficacy of low intensity laser irradiation and sodium nedocromil in the complex treatment of patients with bronchial asthma].

Journal: Terapevticheskii arkhiv 20020101

Title: Twice-daily and once-daily nedocromil sodium 2% ophthalmic solution for the treatment of seasonal allergic conjunctivitis.

Journal: Advances in therapy 20020101

Title: Nedocromil sodium ophthalmic solution 2% twice daily in patients with allergic conjunctivitis.

Journal: Advances in therapy 20020101

Title: Respiratory function changes in a wilderness multisport endurance competition: a prospective case study.

Journal: Wilderness & environmental medicine 20020101

Title: Water aerosols and cough.

Journal: Pulmonary pharmacology & therapeutics 20020101

Title: Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases.

Journal: American journal of therapeutics 20020101

Title: Asthma: knowledge and practice patterns of Louisiana family physicians.

Journal: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20020101

Title: [IL-10 serum levels in children with moderate asthma].

Journal: Pneumonologia i alergologia polska 20020101

Title: 24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139].

Journal: BMC family practice 20020101

Title: [Nedocromil sodium--the influence on allergic inflammation].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20020101

Title: Review: nedocromil sodium decreases airflow reduction and recovery time in exercise-induced bronchoconstriction.

Journal: ACP journal club 20020101

Title: Comparison of emedastine 0.05% or nedocromil sodium 2% eye drops and placebo in controlling local reactions in subjects with allergic conjunctivitis.

Journal: European journal of ophthalmology 20020101

Title: Allergen challenge and deposition of nedocromil sodium in asthma.

Journal: Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 20020101

Title: Spotlight on montelukast in asthma in children 2 to 14 years of age.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101

Title: Inhaled nedocromil sodium for persistent cough in children.

Journal: The Medical journal of Malaysia 20011201

Title: [Asthma in children].

Journal: Zeitschrift fur arztliche Fortbildung und Qualitatssicherung 20011101

Title: Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms.

Journal: The Journal of allergy and clinical immunology 20010901

Title: Budesonide but not nedocromil sodium reduces exhaled nitric oxide levels in asthmatic children.

Journal: Respiratory medicine 20010901

Title: Asthma symptoms, morbidity, and antiinflammatory use in inner-city children.

Journal: Pediatrics 20010801

Title: Bronchial, alveolar, and vascular-induced anaphylaxis and irritant-induced cardiovascular and pulmonary responses.

Journal: Environmental health perspectives 20010801

Title: Interleukin-2 activates human peripheral blood eosinophils.

Journal: Cellular immunology 20010615

Title: Asthma in the hospitalized obstetrical patient.

Journal: Clinical reviews in allergy & immunology 20010601

Title: Double-blind, randomized, placebo-controlled trial of effect of nedocromil sodium on clinical and inflammatory parameters of asthma in children allergic to dust mite.

Journal: Allergy 20010601

Title: Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells.

Journal: Respiratory medicine 20010501

Title: A retrospective study of risk factors for repeated admissions for asthma in a rural/suburban university hospital.

Journal: The Journal of the American Osteopathic Association 20010501

Title: Management of asthma in children.

Journal: American family physician 20010401

Title: Fog-induced respiratory responses are attenuated by nedocromil sodium in humans.

Journal: American journal of respiratory and critical care medicine 20010401

Title: Dehydration behavior of nedocromil magnesium pentahydrate.

Journal: International journal of pharmaceutics 20010314

Title: Exhaled nitric oxide in seasonal allergic rhinitis: influence of pollen season and therapy.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010301

Title: [Anti-allergy therapy in children].

Journal: Allergie et immunologie 20010301

Title: Nedocromil sodium inhibits histamine-induced itch and flare in human skin.

Journal: British journal of pharmacology 20010201

Title: The formulation of powder inhalation systems containing a high mass of nedocromil sodium trihydrate.

Journal: Journal of pharmaceutical sciences 20010201

Title: Is budesonide or nedocromil superior in the long-term management of mild to moderate asthma in children?

Journal: The Journal of family practice 20010101

Title: Newer and alternative non-steroidal treatments for asthmatic inflammation.

Journal: Allergy and asthma proceedings 20010101

Title: Nedocromil sodium versus sodium cromoglycate in treatment of exercise-induced bronchoconstriction: a systematic review.

Journal: The European respiratory journal 20010101

Title: Inhaled hyperosmolar agents for bronchiectasis.

Journal: The Cochrane database of systematic reviews 20010101

Title: [Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].

Journal: Terapevticheskii arkhiv 20010101

Title: Choosing therapy for childhood asthma.

Journal: Paediatric drugs 20010101

Title: Nedocromil sodium in golfers with seasonal allergic conjunctivitis.

Journal: Advances in therapy 20010101

Title: Metering performance of several metered-dose inhalers with different spacers/holding chambers.

Journal: Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 20010101

Title: Inhibition of GM-CSF secretion by topical corticosteroids and nedocromil sodium. A comparison study using nasal polyp epithelial cells.

Journal: Respiratory medicine 20000501

Title: Risk of non-fatal cardiac failure and ischaemic heart disease with long acting beta 2 agonists.

Journal: Thorax 19980701

Title: Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19971201

Title: Effects of nedocromil sodium and WEB 2086 on chemoattractant-stimulated neutrophil migration through cellular and noncellular barriers.

Journal: Annals of allergy 19921001

Title: Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.

Journal: International archives of allergy and applied immunology 19900101

Title: Nedocromil sodium: a new drug for the management of bronchial asthma.

Journal: Thorax 19841101

Title: Wells E, et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mastcells. J Immunol. 1986 Dec 15;137(12):3941-5.

Title: Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8(3):e60827.

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