Home Amines 69308-37-8
69308-37-8,MFCD01321057
Catalog No.:AA0036QJ

69308-37-8 | (R)-4-Amino-3-(4-chlorophenyl)butanoic acid

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25mg
>95.0%(T)(HPLC)
in stock  
$28.00   $20.00
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100mg
>95.0%(T)(HPLC)
in stock  
$71.00   $50.00
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1g
97%
in stock  
$427.00   $299.00
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5g
97%
in stock  
$1,258.00   $881.00
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10g
97%
in stock  
$2,007.00   $1,405.00
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25g
97%
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$4,002.00   $2,802.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0036QJ
Chemical Name:
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
CAS Number:
69308-37-8
Molecular Formula:
C10H12ClNO2
Molecular Weight:
213.6608
MDL Number:
MFCD01321057
SMILES:
NC[C@@H](c1ccc(cc1)Cl)CC(=O)O
Properties
Properties
 
BP:
364.3°C at 760 mmHg  
Form:
Solid  
MP:
171-174°C  
Storage:
2-8℃;Keep in dry area;  

Computed Properties
 
Complexity:
191  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
-1  

Downstream Synthesis Route
(R)-3-(4-Chloro-phenyl)-4-isocyanato-butyricacidmethylester 
  69308-37-8 

[1]CanadianJournalofChemistry,1994,vol.72,p.2312-2317

(R)-baclofen 
  69308-37-8 

[1]CanadianJournalofChemistry,1994,vol.72,p.2312-2317

[1]Tetrahedron,1996,vol.52,p.15117-15126

(3R)-3-(4-chlorophenyl)glutaramide 
  69308-37-8 

[1]JournaloftheChemicalSociety.PerkinTransactions2(2001),1997,p.763-768

[2]Patent:WO2020/141141,2020,A1.Locationinpatent:Page/Pagecolumn23

[1]TetrahedronAsymmetry,1997,vol.8,p.3801-3805

Literature

Title: Discovery of a novel potent GABA(B) receptor agonist.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Efficacy and safety study of arbaclofen placarbil in patients with spasticity due to spinal cord injury.

Journal: Spinal cord 20110901

Title: Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen.

Journal: The Journal of pharmacology and experimental therapeutics 20090901

Title: QSAR and molecular modeling studies of baclofen analogues as GABA(B) agonists. Insights into the role of the aromatic moiety in GABA(B) binding and activation.

Journal: Journal of medicinal chemistry 20010524

Title: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

Journal: Nature 19970320

Title: Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.

Title: Henderson C, et al. Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. Sci Transl Med. 2012 Sep 19;4(152):152ra128.

Title: Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.

Title: Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.

Title: Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

Title: Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

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SDS
Tags:69308-37-8 Molecular Formula|69308-37-8 MDL|69308-37-8 SMILES|69308-37-8 (R)-4-Amino-3-(4-chlorophenyl)butanoic acid