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69712-56-7,MFCD00864983
Catalog No.:AA0068OI

69712-56-7 | Cefotetan

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5mg
95%
in stock  
$65.00   $45.00
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100mg
95
in stock  
$78.00   $55.00
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250mg
95
in stock  
$81.00   $57.00
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500mg
95
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0068OI
Chemical Name:
Cefotetan
CAS Number:
69712-56-7
Molecular Formula:
C17H17N7O8S4
Molecular Weight:
575.6190
MDL Number:
MFCD00864983
SMILES:
CO[C@@]1(NC(=O)C2S/C(=C(\C(=O)O)/C(=O)N)/S2)C(=O)N2[C@@H]1SCC(=C2C(=O)O)CSc1nnnn1C
Properties
Properties
 
Form:
Solid  
MP:
173-178°C (dec.)  
Refractive Index:
1.7400 (estimate)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
1090  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
0.1  

Literature

Title: A systematic toxicity evaluation of cephalosporins via transcriptomics in zebrafish and in silico ADMET studies.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180601

Title: Toxic effect prediction of cefatirizine amidine sodium and its impurities by structure-toxicity relationship of cephalosporins.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20121001

Title: Immune hemolytic anemia caused by drugs.

Journal: Expert opinion on drug safety 20120701

Title: [Analysis of resistance phenotype and homology of Klebsiella pneumoniae in burn patients].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20120401

Title: Pain after laparoscopic appendectomy: a comparison of transumbilical single-port and conventional laparoscopic surgery.

Journal: Journal of the Korean Surgical Society 20120301

Title: Phenotypic & molecular characterization of AmpC β-lactamases among Escherichia coli, Klebsiella spp. & Enterobacter spp. from five Indian Medical Centers.

Journal: The Indian journal of medical research 20120301

Title: Molecular description of plasmid-mediated AmpC β-lactamases among nosocomial isolates of Escherichia coli & Klebsiella pneumoniae from six different hospitals in India.

Journal: The Indian journal of medical research 20120101

Title: Upper respiratory tract colonization by gram-negative rods in patients with chronic lymphocytic leukemia: analysis of risk factors.

Journal: TheScientificWorldJournal 20120101

Title: An ileal Crohn's disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsies.

Journal: PloS one 20120101

Title: Pharmacokinetic differences between the epimers of cefotetan disodium after single intravenous injection in healthy Chinese volunteers.

Journal: European journal of drug metabolism and pharmacokinetics 20111201

Title: Selection of prophylactic antimicrobial agent may affect incidence of infection in small bowel and colorectal surgery.

Journal: Surgical infections 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Maximal Points of Head's Zone in Fixed Drug Eruption.

Journal: Annals of dermatology 20111201

Title: A case of a shiga toxin producing Escherichia coli.

Journal: Yonsei medical journal 20111101

Title: Prevalence of and Risk Factors for Levofloxacin-Resistant E. coli Isolated from Outpatients with Urinary Tract Infection.

Journal: Korean journal of urology 20110801

Title: Pathology consultation on drug-induced hemolytic anemia.

Journal: American journal of clinical pathology 20110701

Title: Results of urine culture and antimicrobial sensitivity tests according to the voiding method over 10 years in patients with spinal cord injury.

Journal: Korean journal of urology 20110501

Title: Characterization of Pseudomonas aeruginosa strains isolated from burned patients hospitalized in a major burn center in Tehran, Iran.

Journal: Acta medica Iranica 20110101

Title: Treatment of acute pelvic inflammatory disease.

Journal: Infectious diseases in obstetrics and gynecology 20110101

Title: Oral metronidazole as antibiotic prophylaxis for patients with nonperforated appendicitis.

Journal: Clinical and experimental gastroenterology 20110101

Title: Piperacillin-induced immune hemolysis presenting with tachycardia and cardiac arrest.

Journal: Case reports in medicine 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Radiation recall with anticancer agents.

Journal: The oncologist 20101101

Title: Investigation of toxin gene diversity, molecular epidemiology, and antimicrobial resistance of Clostridium difficile isolated from 12 hospitals in South Korea.

Journal: The Korean journal of laboratory medicine 20101001

Title: Pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study.

Journal: Clinical therapeutics 20100901

Title: Failure to administer cefotan: was standing order ambiguous? Tucker v. Women's Care Physicians of Louisville, CA-001929-mr(6/18/2010)-KY.

Journal: Nursing law's Regan report 20100801

Title: Use of optical mapping to sort uropathogenic Escherichia coli strains into distinct subgroups.

Journal: Microbiology (Reading, England) 20100701

Title: Prevalence and risk factors for extended spectrum Beta-lactamase-producing uropathogens in patients with urinary tract infection.

Journal: Korean journal of urology 20100701

Title: Cefotetan versus conventional triple antibiotic prophylaxis in elective colorectal cancer surgery.

Journal: Journal of Korean medical science 20100301

Title: Detection of AmpC beta-lactamases in Escherichia coli, Klebsiella spp., Salmonella spp. and Proteus mirabilis in a regional clinical microbiology laboratory.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100201

Title: Drug-induced immune hemolytic anemia.

Journal: Clinical advances in hematology & oncology : H&O 20100201

Title: A focus on intra-abdominal infections.

Journal: World journal of emergency surgery : WJES 20100101

Title: Tuboovarian abscesses: is size associated with duration of hospitalization & complications?

Journal: Obstetrics and gynecology international 20100101

Title: Piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis.

Journal: Case reports in medicine 20100101

Title: Immune hemolytic anemia associated with drug therapy.

Journal: Blood reviews 20100101

Title: Extended-spectrum β-lactamases in Gram Negative Bacteria.

Journal: Journal of global infectious diseases 20100101

Title: Ampicillin/sulbactam versus cefuroxime as antimicrobial prophylaxis for cesarean delivery: a randomized study.

Journal: BMC infectious diseases 20100101

Title: Comparative evaluation of prophylactic single-dose intravenous antibiotic with postoperative antibiotics in elective urologic surgery.

Journal: Therapeutics and clinical risk management 20100101

Title: Impact of surgical site infections on length of stay and costs in selected colorectal procedures.

Journal: Surgical infections 20091201

Title: Comparison of 3 phenotypic-detection methods for identifying plasmid-mediated AmpC beta-lactamase-producing Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis strains.

Journal: The Korean journal of laboratory medicine 20091001

Title: Resistance trends of Bacteroides fragilis group over an 8-year period, 1997-2004, in Korea.

Journal: The Korean journal of laboratory medicine 20090801

Title: The first case of antibiotic-associated colitis by Clostridium difficile PCR ribotype 027 in Korea.

Journal: Journal of Korean medical science 20090601

Title: Infection after elective colorectal surgery: bacteriological analysis of failures in a randomized trial of cefotetan vs. ertapenem prophylaxis.

Journal: Surgical infections 20090401

Title: Clinical significance of anaerobic infections.

Journal: The Korean journal of internal medicine 20090301

Title: New disturbing trend in antimicrobial resistance of gram-negative pathogens.

Journal: PLoS pathogens 20090301

Title: CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea.

Journal: Journal of medical microbiology 20090201

Title: [Evaluation of the MicroScan NegCombo panel Type 44 for detection of extended-spectrum beta-lactamase among clinical isolates of Escherichia coli, Klebsiella species, and Proteus mirabilis].

Journal: The Korean journal of laboratory medicine 20090201

Title: Species distribution and antimicrobial susceptibility of gram-negative aerobic bacteria in hospitalized cancer patients.

Journal: Journal of translational medicine 20090101

Title: Penetrating abdominal injuries: management controversies.

Journal: Scandinavian journal of trauma, resuscitation and emergency medicine 20090101

Title: Laparoscopic appendectomy performed by residents and experienced surgeons.

Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons 20090101

Title: Antimicrobial prophylaxis in colorectal surgery: focus on ertapenem.

Journal: Therapeutics and clinical risk management 20090101

Title: Extended Spectrum beta-Lactamases among Gram-Negative Bacterial Isolates from Clinical Specimens in Three Major Hospitals in Northern Jordan.

Journal: International journal of microbiology 20090101

Title: Increased incidence of postoperative infections during prophylaxis with cephalothin compared to doxycycline in intestinal surgery.

Journal: BMC surgery 20090101

Title: Drug-induced immune hemolytic anemia.

Journal: Hematology. American Society of Hematology. Education Program 20090101

Title: High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.

Journal: PloS one 20090101

Title: Recent changes in the epidemiology and management of extended-spectrum β-lactamase-producing Enterobacteriaceae.

Journal: F1000 medicine reports 20090101

Title: Effects of treatment with antimicrobial agents on the human colonic microflora.

Journal: Therapeutics and clinical risk management 20081201

Title: Conservative management of postoperative Fever in gynecologic patients undergoing major abdominal or vaginal operations.

Journal: Journal of the American College of Surgeons 20080901

Title: Definitive risk factors for anastomotic leaks in elective open colorectal resection.

Journal: Archives of surgery (Chicago, Ill. : 1960) 20080901

Title: Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601

Title: Antibiotic prophylaxis for prevention of postpartum perineal wound complications: a randomized controlled trial.

Journal: Obstetrics and gynecology 20080601

Title: Comparative costs of ertapenem and cefotetan as prophylaxis for elective colorectal surgery.

Journal: Surgical infections 20080601

Title: National hospital survey of anaerobic culture and susceptibility methods: III.

Journal: Anaerobe 20080401

Title: Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery.

Journal: Surgical infections 20080401

Title: Prevalence and antimicrobial susceptibility pattern of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the United Arab Emirates.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

Title: Radiation recall dermatitis: case report and review of the literature.

Journal: Current oncology (Toronto, Ont.) 20080101

Title: An overview of harms associated with beta-lactam antimicrobials: where do the carbapenems fit in?

Journal: Critical care (London, England) 20080101

Title: Clinical review: balancing the therapeutic, safety, and economic issues underlying effective antipseudomonal carbapenem use.

Journal: Critical care (London, England) 20080101

Title: Fatal drug-induced immune hemolytic anemia due to cefotetan; A case study.

Journal: Asian journal of transfusion science 20080101

Title: Alistipes finegoldii in blood cultures from colon cancer patients.

Journal: Emerging infectious diseases 20070801

Title: False susceptibility to cefotetan reported by MicroScan for DHA-type AmpC beta-lactamase-producing Klebsiella pneumoniae.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20070501

Title: Antibiotic prophylaxis in colorectal surgery.

Journal: The New England journal of medicine 20070419

Title: One center's experience: the serology and drugs associated with drug-induced immune hemolytic anemia--a new paradigm.

Journal: Transfusion 20070401

Title: Use of boronic acid disk methods to detect the combined expression of plasmid-mediated AmpC beta-lactamases and extended-spectrum beta-lactamases in clinical isolates of Klebsiella spp., Salmonella spp., and Proteus mirabilis.

Journal: Diagnostic microbiology and infectious disease 20070301

Title: Population-based laboratory surveillance for AmpC beta-lactamase-producing Escherichia coli, Calgary.

Journal: Emerging infectious diseases 20070301

Title: Polyethylene glycol versus sodium phosphate mechanical bowel preparation in elective colorectal surgery.

Journal: American journal of surgery 20070201

Title: Third Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria.

Journal: The Journal of antimicrobial chemotherapy 20070101

Title: Incidence of multidrug-resistant organisms causing ventilator-associated pneumonia in a tertiary care hospital: a nine months' prospective study.

Journal: Annals of thoracic medicine 20070101

Title: Ertapenem versus cefotetan prophylaxis in elective colorectal surgery.

Journal: The New England journal of medicine 20061221

Title: Carbapenems for surgical prophylaxis?

Journal: The New England journal of medicine 20061221

Title: Meropenem in the treatment of complicated skin and soft tissue infections.

Journal: Therapeutics and clinical risk management 20061201

Title: Molecular epidemiology of clinical isolates of ampc producing Klebsiella pneumoniae.

Journal: Indian journal of medical microbiology 20060701

Title: Antimicrobial susceptibility of anaerobic bacteria in New Zealand: 1999-2003.

Journal: The Journal of antimicrobial chemotherapy 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effect of human immunodeficiency virus-1 infection on treatment outcome of acute salpingitis.

Journal: Obstetrics and gynecology 20060401

Title: Cefotetan-induced life-threatening haemolysis.

Journal: The Medical journal of Australia 20060306

Title: Cefotetan-induced hemolytic anemia after perioperative prophylaxis.

Journal: American journal of hematology 20060301

Title: Further increase of vancomycin-resistant Enterococcus faecium, amikacin- and fluoroquinolone-resistant Klebsiella pneumoniae, and imipenem-resistant Acinetobacter spp. in Korea: 2003 KONSAR surveillance.

Journal: Yonsei medical journal 20060227

Title: Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand.

Journal: BMC infectious diseases 20060101

Title: Cefotetan-induced hemolytic anemia after bariatric procedures.

Journal: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 20060101

Title: Radiation recall dermatitis with cefotetan: a case study.

Journal: The oncologist 20060101

Title: Susceptibility testing accuracy of a CTX-M-type extended-spectrum beta-lactamase organism-producing population of Enterobacteriaceae: intermethod analysis for 9 beta-lactams.

Journal: Diagnostic microbiology and infectious disease 20051001

Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Journal: Journal of pharmaceutical sciences 20050701

Title: The changing spectrum of drug-induced immune hemolytic anemia.

Journal: Seminars in hematology 20050701

Title: Reevaluation of Enterobacteriaceae MIC/disk diffusion zone diameter regression scattergrams for 9 beta-lactams: adjustments of breakpoints for strains producing extended spectrum beta-lactamases.

Journal: Diagnostic microbiology and infectious disease 20050701

Title: In vitro evaluation of faropenem activity against anaerobic bacteria.

Journal: Journal of chemotherapy (Florence, Italy) 20050201

Title: Antimicrobial susceptibility of bifidobacteria.

Journal: The Journal of antimicrobial chemotherapy 20050101

Title: Dissemination of Escherichia coli producing AmpC-type beta-lactamase (CMY-11) in Korea.

Journal: International journal of antimicrobial agents 20041001

Title: Persistence of cefotetan on red blood cells.

Journal: Transfusion 20040601

Title: [Very severe pregnancy hemolysis...].

Journal: La Revue de medecine interne 20040601

Title: Small intestinal submucosa for vascular reconstruction in the presence of gastrointestinal contamination.

Journal: Annals of surgery 20040501

Title: Bleeding and thrombosis in high-risk renal transplantation candidates using heparin.

Journal: The Annals of pharmacotherapy 20040401

Title: Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci.

Journal: The Journal of infectious diseases 20040315

Title: Fitz-Hugh-Curtis syndrome: a diagnosis to consider in women with right upper quadrant pain.

Journal: Cleveland Clinic journal of medicine 20040301

Title: Clinical and laboratory study of an episode of cefotetan-induced severe hemolytic anemia.

Journal: Hematology (Amsterdam, Netherlands) 20040201

Title: Escherichia coli producing CTX-M-2 beta-lactamase in cattle, Japan.

Journal: Emerging infectious diseases 20040101

Title: [Study of resistance mechanism on cefotaxime resistant Proteus mirabilis isolated from clinical specimens and its clinical background].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20040101

Title: Analysis of freshwater pathogens: a guide to rational empiric antibiotic coverage.

Journal: Missouri medicine 20040101

Title: Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery.

Journal: Immunohematology 20040101

Title: Dissemination of transferable AmpC-type beta-lactamase (CMY-10) in a Korean hospital.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20040101

Title: [Mechanisms of resistance in Enterobacteriaceae towards beta-lactamase antibiotics].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20040101

Title: A negative or very weakly positive DAT should not exclude investigation of drug-induced immune hemolytic anemia.

Journal: Transfusion 20031101

Title: Antibiotics in tactical combat casualty care 2002.

Journal: Military medicine 20031101

Title: Clinical and microbiologic analysis of a hospital's extended-spectrum beta-lactamase-producing isolates over a 2-year period.

Journal: Pharmacotherapy 20031001

Title: Randomized clinical trial of extended spectrum antibiotic prophylaxis with coverage for Ureaplasma urealyticum to reduce post-cesarean delivery endometritis.

Journal: Obstetrics and gynecology 20030601

Title: Antibiotic resistance among anaerobic Gram-negative bacilli: lessons from a French multicentric survey.

Journal: Anaerobe 20030601

Title: AIDS presenting with cutaneous Kaposi's sarcoma and bacillary angiomatosis in the bone marrow mimicking Kaposi's sarcoma.

Journal: AIDS patient care and STDs 20021201

Title: Comparison of screening methods for TEM- and SHV-derived extended-spectrum beta-lactamase detection.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021101

Title: Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin.

Journal: American journal of clinical pathology 20020801

Title: What is your diagnosis? Splenic torsion.

Journal: Journal of the American Veterinary Medical Association 20020401

Title: [Identification of plasmid-encoded cephalosporinase ACC-1 among various enterobacteria (Klebsiella pneumoniae, Proteus mirabilis, Salmonella) isolated from a Tunisian hospital (Sfax 997-2000)].

Journal: Pathologie-biologie 20020201

Title: Surgical prophylaxis in practice.

Journal: The Journal of hospital infection 20020101

Title: Cefotetan-induced haemolytic anaemia. A review of 85 cases.

Journal: Adverse drug reactions and toxicological reviews 20020101

Title: Practical aspects of investigating drug-induced immune hemolytic anemia due to cefotetan or ceftriaxone-a case study approach.

Journal: Immunohematology 20020101

Title: Bacteroides fragilis arthritis in a patient with sickle cell disease.

Journal: The American journal of medicine 20010801

Title: Antibiotic therapy in intra-abdominal infections--a review on randomised clinical trials.

Journal: European journal of medical research 20010730

Title: In vitro susceptibility of Vibrio spp. isolated from the environment.

Journal: International journal of antimicrobial agents 20010501

Title: Delayed hypersensitivity to cefotetan.

Journal: Allergy 20010301

Title: Bacteroides fragilis-induced intra-abdominal abscess in an experimental model treated with telithromycin (HMR 3647).

Journal: Chemotherapy 20010101

Title: Optimizing antibiotic therapy in the intensive care unit setting.

Journal: Critical care (London, England) 20010101

Title: Cutaneous drug reaction case reports: from the world literature.

Journal: American journal of clinical dermatology 20010101

Title: Delayed onset of life-threatening immune hemolysis after perioperative antimicrobial prophylaxis with cefotetan.

Journal: Canadian journal of surgery. Journal canadien de chirurgie 20001201

Title: Cefotetan-induced hemolytic anemia: a case report and review of the literature.

Journal: Archives of pathology & laboratory medicine 20000901

Title: Cefotetan-induced hemolysis associated with antibiotic prophylaxis for cesarean delivery.

Journal: American journal of obstetrics and gynecology 20000601

Title: Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction.

Journal: American journal of hematology 20000501

Title: Severe immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and gynecologic procedures.

Journal: American journal of obstetrics and gynecology 19990701

Title: Species specificity of 2-aryl carbapenem-induced immune-mediated hemolytic anemia in primates.

Journal: Toxicology 19960430

Title: Cefotetan-induced immune hemolytic anemia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19921101

Title: Cephalosporin-induced hemolysis: a case report and review of the literature.

Journal: American journal of hematology 19920601

Title: Cefotetan-induced singultus.

Journal: Annals of internal medicine 19920315

Title: Cefotetan disodium-induced hemolytic anemia.

Journal: The Annals of pharmacotherapy 19920201

Title: Severe immune-mediated hemolytic anemia secondary to treatment with cefotetan.

Journal: Transfusion 19920101

Title: Fatal immune hemolytic anemia due to cefotetan.

Journal: Transfusion 19920101

Title: Acute interstitial nephritis associated with cefotetan therapy.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 19900901

Title: Shi S, et al. Pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study.

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Tags:69712-56-7 Molecular Formula|69712-56-7 MDL|69712-56-7 SMILES|69712-56-7 Cefotetan