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69975-86-6,MFCD00865218
Catalog No.:AA00IBX4

69975-86-6 | 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione

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1g
>98.0%(T)(HPLC)
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5g
98%(HPLC)
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25g
>98.0%(T)(HPLC)
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500g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IBX4
Chemical Name:
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
CAS Number:
69975-86-6
Molecular Formula:
C11H14N4O4
Molecular Weight:
266.2533
MDL Number:
MFCD00865218
SMILES:
Cn1c(=O)n(C)c2c(c1=O)n(cn2)CC1OCCO1
NSC Number:
759645
Properties
Computed Properties
 
Complexity:
398  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
2  
XLogP3:
-0.9  

Literature

Title: [Clinical observation of home noninvasive positive pressure ventilation in hypercapnic patient with stable severe chronic obstructive pulmonary disease].

Journal: Zhonghua yi xue za zhi 20120214

Title: The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism.

Journal: Pulmonary pharmacology & therapeutics 20120201

Title: In vitro and in vivo evaluation of multilayered pastilles for chronotherapeutic management of nocturnal asthma.

Journal: Expert opinion on drug delivery 20120101

Title: Severe drug hypersensitivity induced by erdosteine and doxofylline as confirmed by patch and lymphocyte transformation tests: a case report.

Journal: Journal of investigational allergology & clinical immunology 20120101

Title: Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111001

Title: Effects of high-dose mucosolvin on lung functions in infant patients with cardiopulmonary bypass.

Journal: The heart surgery forum 20110801

Title: Stability and compatibility of doxofylline with phentolamine mesilate in 0.9% sodium chloride or 5% dextrose injection for intravenous infusion.

Journal: Journal of clinical pharmacy and therapeutics 20110201

Title: Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo.

Journal: International journal of nanomedicine 20110101

Title: 7-(1,3-Dioxolan-2-ylmethyl)-1,3-di-methyl-2,6-dioxo-2,3,6,7-tetra-hydro-1H-purin-9-ium tetra-chloridoferrate(III).

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: Doxofylline: a 'novofylline'.

Journal: Pulmonary pharmacology & therapeutics 20100801

Title: [Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401

Title: [Meta-analysis of efficacy and safety of oral theophylline in chronic obstructive pulmonary disease].

Journal: Zhonghua yi xue za zhi 20100302

Title: A randomized, open labeled, comparative study to assess the efficacy and safety of controller medications as add on to inhaled corticosteroid and long-acting β2 agonist in the treatment of moderate-to-severe persistent asthma.

Journal: Journal of postgraduate medicine 20100101

Title: Spectrophotometric and reversed-phase high-performance liquid chromatographic method for the determination of doxophylline in pharmaceutical formulations.

Journal: Journal of young pharmacists : JYP 20100101

Title: Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease.

Journal: Expert opinion on pharmacotherapy 20091001

Title: Treatment of moderate chronic obstructive pulmonary disease (stable) with doxofylline compared with slow release theophylline--a multicentre trial.

Journal: Journal of the Indian Medical Association 20081201

Title: [Determination of levosimendan and its main metabolites in human plasma with HPLC-MS/MS method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081001

Title: Preparation and bioavailability of sustained-release doxofylline pellets in beagle dogs.

Journal: Drug development and industrial pharmacy 20080701

Title: Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of doxofylline in human serum: application to a clinical pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20080601

Title: Doxofylline: The next generation methylxanthine.

Journal: Indian journal of pediatrics 20080301

Title: Doxofyllinium tetra-chloridoanti-monate(III) monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Therapeutic potential of adenosine receptor antagonists and agonists.

Journal: Expert opinion on therapeutic patents 20070801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20051201

Title: [Clinical study on doxofylline injection in treatment of children with acute asthma attacks].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20040201

Title: Methylxanthines for exacerbations of chronic obstructive pulmonary disease: meta-analysis of randomised trials.

Journal: BMJ (Clinical research ed.) 20030920

Title: Conclusion without support - remarks on 'Efficacy and safely of doxyphyllin compared to Theophylline in chronic reversible asthma- a double-blind randomized placebo-controlled multicentre trial' by Goldstein MF, Chervinsky P (published in MedSciMonit, 2002; 8(4):CR297-304.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020801

Title: Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020401

Title: Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects.

Journal: Current medical research and opinion 20010101

Title: Methyl-xanthines for exacerbations of chronic obstructive pulmonary disease.

Journal: The Cochrane database of systematic reviews 20010101

Title: Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure.

Journal: Chest 19891001

Title: Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors.

Journal: Archives internationales de pharmacodynamie et de therapie 19880101

Title: Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.

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SDS
Tags:69975-86-6 Molecular Formula|69975-86-6 MDL|69975-86-6 SMILES|69975-86-6 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione