71800-36-7,MFCD00079826
Catalog No.:AA00FAGG

71800-36-7 | LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE

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Purity
Availability
Price(USD)
Quantity
  
5mg
2 weeks  
$545.00   $382.00
- +
10mg
2 weeks  
$813.00   $569.00
- +
25mg
2 weeks  
$1,483.00   $1,038.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FAGG
Chemical Name:
LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
CAS Number:
71800-36-7
Molecular Formula:
C50H73N13O11
Molecular Weight:
1032.1951
MDL Number:
MFCD00079826
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)CO)Cc1ccccc1)CCCNC(=N)N)N
Properties
Computed Properties
 
Complexity:
1960  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
74  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
11  
Isotope Atom Count:
0  
Rotatable Bond Count:
27  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-3.8  

Literature

Title: Expression and function of TLR4- induced B1R bradykinin receptor on cardiac fibroblasts.

Journal: Toxicology and applied pharmacology 20180715

Title: Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.

Journal: Toxicology and applied pharmacology 20120615

Title: Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

Journal: PloS one 20120101

Title: Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Journal: American journal of physiology. Renal physiology 20110501

Title: Enalaprilat-mediated activation of kinin b(1) receptors and vasodilation in the rat isolated perfused kidney.

Journal: Pharmacology 20110101

Title: Bradykinin-related peptides up-regulate the expression of kinin B1 and B2 receptor genes in human promonocytic cell line U937.

Journal: Acta biochimica Polonica 20090101

Title: Vascular B1 kinin receptors in patients with congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20081101

Title: Cardiovascular expression of inflammatory signaling molecules, the kinin B1 receptor and COX2, in the rabbit: effects of LPS, anti-inflammatory and anti-hypertensive drugs.

Journal: Regulatory peptides 20080207

Title: Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins.

Journal: International immunopharmacology 20080201

Title: Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501

Title: Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.

Journal: Journal of neurosurgery. Spine 20070501

Title: Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Journal: British journal of pharmacology 20070101

Title: The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.

Journal: European journal of pharmacology 20061203

Title: Kinins and neuroinflammation: dual effect on prostaglandin synthesis.

Journal: European journal of pharmacology 20060928

Title: Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts.

Journal: The Journal of biological chemistry 20050415

Title: B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050401

Title: Induction of B1 bradykinin receptors in the kindled hippocampus increases extracellular glutamate levels: a microdialysis study.

Journal: Neuroscience 20050101

Title: Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.

Journal: European journal of pharmacology 20040919

Title: Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.

Journal: European journal of pharmacology 20030829

Title: Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor?

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: High agonist-independent clearance of rabbit kinin B1 receptors in cultured cells.

Journal: American journal of physiology. Heart and circulatory physiology 20030501

Title: Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.

Journal: The Journal of biological chemistry 20020510

Title: Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts.

Journal: Molecular pharmacology 20020301

Title: No evidence for bradykinin B1 receptors in rat dorsal root ganglion neurons.

Journal: Neuroreport 20011008

Title: Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Functional studies of bradykinin receptors in Chinese hamster ovary cells stably expressing the human B2 bradykinin receptor.

Journal: International immunopharmacology 20010501

Title: Detection of bradykinin B1 receptors in rat aortic smooth muscle cells.

Journal: Biochemical pharmacology 20010201

Title: Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.

Journal: Journal of gastroenterology and hepatology 20010101

Title: Molecular characterisation of cloned bradykinin B1 receptors from rat and human.

Journal: European journal of pharmacology 19990625

Title: Effect of dexamethasone on cyclophosphamide-induced cystitis in rats: lack of relation with bradykinin B1 receptor-mediated motor responses.

Journal: European journal of pharmacology 19990312

Title: Stable expression of human kinin B1 receptor in 293 cells: pharmacological and functional characterization.

Journal: British journal of pharmacology 19970901

Title: Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways.

Journal: The Journal of biological chemistry 19970425

Title: The agonist selectivity of a mouse B1 bradykinin receptor differs from human and rabbit B1 receptors.

Journal: Immunopharmacology 19960601

Title: Expression cloning of a human B1 bradykinin receptor.

Journal: The Journal of biological chemistry 19940826

Title: Differential pharmacology of cloned human and mouse B2 bradykinin receptors.

Journal: Molecular pharmacology 19940101

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SDS
Historical Records
Tags:71800-36-7 Molecular Formula|71800-36-7 MDL|71800-36-7 SMILES|71800-36-7 LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
Catalog No.: AA00FAGG
71800-36-7,MFCD00079826
71800-36-7 | LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
Pack Size: 5mg
Purity:
2 weeks
$545.00 $382.00
Pack Size: 10mg
Purity:
2 weeks
$813.00 $569.00
Pack Size: 25mg
Purity:
2 weeks
$1,483.00 $1,038.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FAGG
Chemical Name: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
CAS Number: 71800-36-7
Molecular Formula: C50H73N13O11
Molecular Weight: 1032.1951
MDL Number: MFCD00079826
SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)CO)Cc1ccccc1)CCCNC(=N)N)N
Properties
Complexity: 1960  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 8  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 74  
Hydrogen Bond Acceptor Count: 14  
Hydrogen Bond Donor Count: 11  
Isotope Atom Count: 0  
Rotatable Bond Count: 27  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -3.8  
Literature fold

Title: Expression and function of TLR4- induced B1R bradykinin receptor on cardiac fibroblasts.

Journal: Toxicology and applied pharmacology20180715

Title: Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.

Journal: Toxicology and applied pharmacology20120615

Title: Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

Journal: PloS one20120101

Title: Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Journal: American journal of physiology. Renal physiology20110501

Title: Enalaprilat-mediated activation of kinin b(1) receptors and vasodilation in the rat isolated perfused kidney.

Journal: Pharmacology20110101

Title: Bradykinin-related peptides up-regulate the expression of kinin B1 and B2 receptor genes in human promonocytic cell line U937.

Journal: Acta biochimica Polonica20090101

Title: Vascular B1 kinin receptors in patients with congestive heart failure.

Journal: Journal of cardiovascular pharmacology20081101

Title: Cardiovascular expression of inflammatory signaling molecules, the kinin B1 receptor and COX2, in the rabbit: effects of LPS, anti-inflammatory and anti-hypertensive drugs.

Journal: Regulatory peptides20080207

Title: Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins.

Journal: International immunopharmacology20080201

Title: Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

Journal: The Journal of pharmacology and experimental therapeutics20070801

Title: Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20070501

Title: Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.

Journal: Journal of neurosurgery. Spine20070501

Title: Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Journal: British journal of pharmacology20070101

Title: The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.

Journal: European journal of pharmacology20061203

Title: Kinins and neuroinflammation: dual effect on prostaglandin synthesis.

Journal: European journal of pharmacology20060928

Title: Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics20060301

Title: Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts.

Journal: The Journal of biological chemistry20050415

Title: B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure.

Journal: Arteriosclerosis, thrombosis, and vascular biology20050401

Title: Induction of B1 bradykinin receptors in the kindled hippocampus increases extracellular glutamate levels: a microdialysis study.

Journal: Neuroscience20050101

Title: Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.

Journal: European journal of pharmacology20040919

Title: Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.

Journal: European journal of pharmacology20030829

Title: Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor?

Journal: American journal of physiology. Heart and circulatory physiology20030701

Title: High agonist-independent clearance of rabbit kinin B1 receptors in cultured cells.

Journal: American journal of physiology. Heart and circulatory physiology20030501

Title: Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.

Journal: The Journal of biological chemistry20020510

Title: Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts.

Journal: Molecular pharmacology20020301

Title: No evidence for bradykinin B1 receptors in rat dorsal root ganglion neurons.

Journal: Neuroreport20011008

Title: Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts.

Journal: The Journal of pharmacology and experimental therapeutics20010701

Title: Functional studies of bradykinin receptors in Chinese hamster ovary cells stably expressing the human B2 bradykinin receptor.

Journal: International immunopharmacology20010501

Title: Detection of bradykinin B1 receptors in rat aortic smooth muscle cells.

Journal: Biochemical pharmacology20010201

Title: Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.

Journal: Journal of gastroenterology and hepatology20010101

Title: Molecular characterisation of cloned bradykinin B1 receptors from rat and human.

Journal: European journal of pharmacology19990625

Title: Effect of dexamethasone on cyclophosphamide-induced cystitis in rats: lack of relation with bradykinin B1 receptor-mediated motor responses.

Journal: European journal of pharmacology19990312

Title: Stable expression of human kinin B1 receptor in 293 cells: pharmacological and functional characterization.

Journal: British journal of pharmacology19970901

Title: Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways.

Journal: The Journal of biological chemistry19970425

Title: The agonist selectivity of a mouse B1 bradykinin receptor differs from human and rabbit B1 receptors.

Journal: Immunopharmacology19960601

Title: Expression cloning of a human B1 bradykinin receptor.

Journal: The Journal of biological chemistry19940826

Title: Differential pharmacology of cloned human and mouse B2 bradykinin receptors.

Journal: Molecular pharmacology19940101

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