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72786-12-0,MFCD00153828
Catalog No.:AA00FM9N

72786-12-0 | CU-32-085

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10mg
≥99%(HPLC)
in stock  
$418.00   $293.00
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50mg
≥99%(HPLC)
in stock  
$1,563.00   $1,094.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FM9N
Chemical Name:
CU-32-085
CAS Number:
72786-12-0
Molecular Formula:
C18H27ClN4O2S
Molecular Weight:
398.9506
MDL Number:
MFCD00153828
SMILES:
CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C.Cl
Properties
Computed Properties
 
Complexity:
605  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Literature

Title: The N-terminal region of the human 5-HT₂C receptor has as a cleavable signal peptide.

Journal: European journal of pharmacology 20120605

Title: Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT₂C agonists.

Journal: Bioorganic & medicinal chemistry letters 20120401

Title: Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP.

Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120201

Title: Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus.

Journal: Neuropharmacology 20110901

Title: Reversal of haloperidol-induced motor deficits by mianserin and mesulergine in rats.

Journal: Pakistan journal of pharmaceutical sciences 20110101

Title: Differences between human wild-type and C23S variant 5-HT2C receptors in inverse agonist-induced resensitization.

Journal: Pharmacological reports : PR 20110101

Title: Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri.

Journal: Epilepsy & behavior : E&B 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart.

Journal: Clinical and experimental pharmacology & physiology 20071101

Title: Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

Journal: Bioorganic & medicinal chemistry letters 20070201

Title: Hypothalamic 5-HT functional regulation through 5-HT1A and 5-HT2C receptors during pancreatic regeneration.

Journal: Life sciences 20060227

Title: Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor.

Journal: European journal of pharmacology 20060217

Title: Effects of mu-CPP and mesulergine on dietary choices in deprived rats: possible mechanisms of their action.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060101

Title: Combined treatment with citalopram and buspirone: effects on serotonin 5-HT2A and 5-HT2C receptors in the rat brain.

Journal: Pharmacopsychiatry 20060101

Title: Fatty acids differentially affect serotonin receptor and transporter binding in the rat brain.

Journal: Neuroscience 20060101

Title: Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes.

Journal: Assay and drug development technologies 20051201

Title: Serotonin 5-HT2C receptor-mediated phosphoinositide hydrolysis in rat choroid plexus after fluoxetine and citalopram treatments.

Journal: Pharmacological research 20050501

Title: Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats.

Journal: Molecular and cellular biochemistry 20050401

Title: Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice.

Journal: Psychopharmacology 20041001

Title: Comparison of G-protein selectivity of human 5-HT2C and 5-HT1A receptors.

Journal: Annals of the New York Academy of Sciences 20041001

Title: Regulation of serotonin 5-HT2C receptors by chronic ligand exposure.

Journal: European journal of pharmacology 20040913

Title: Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors.

Journal: European journal of pharmacology 20040714

Title: Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species.

Journal: British journal of pharmacology 20040101

Title: Up-regulation of 5-HT2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration.

Journal: Neurochemical research 20020201

Title: Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds.

Journal: Molecular pharmacology 20011201

Title: 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats.

Journal: European journal of pharmacology 20011130

Title: Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA.

Journal: Synapse (New York, N.Y.) 20011001

Title: No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.

Journal: European journal of pharmacology 20010914

Title: RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity.

Journal: British journal of pharmacology 20010901

Title: Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone.

Journal: European journal of pharmacology 20010803

Title: High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.

Journal: Journal of neurochemistry 19990501

Title: Activating mutations of the serotonin 5-HT2C receptor.

Journal: Journal of neurochemistry 19970901

Title: Effect of mesulergine on prolactin secretion and dopamine D2 receptors-adaptive changes in diethylstilbestrol-induced hyperplasia of the rat anterior pituitary.

Journal: Endocrine regulations 19920301

Title: Mechanism of action and tolerance of mesulergine.

Journal: Clinical pharmacology and therapeutics 19841101

Title: Treatment of Parkinson's disease with 8-alpha-amino-ergoline, CU 32-085.

Journal: Neurology 19830401

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