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73168-24-8,MFCD00076747
Catalog No.:AA00FAGC

73168-24-8 | 3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2

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5mg
>96%
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$454.00   $318.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FAGC
Chemical Name:
3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
CAS Number:
73168-24-8
Molecular Formula:
C52H74N14O12S2
Molecular Weight:
1151.3606
MDL Number:
MFCD00076747
SMILES:
COc1ccc(cc1)C[C@@H]1NC(=O)CC2(CCCCC2)SSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccccc1)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(=N)N
Properties
Computed Properties
 
Complexity:
2220  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
80  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
20  
XLogP3:
-2.1  

Literature

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry 20130501

Title: Central vasopressin V1A receptor blockade impedes hypothalamic-pituitary-adrenal habituation to repeated restraint stress exposure in adult male rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20121101

Title: Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.

Journal: Journal of neuroendocrinology 20120401

Title: Central apelin-13 inhibits food intake via the CRF receptor in mice.

Journal: Peptides 20120101

Title: Gestational valproate alters BOLD activation in response to complex social and primary sensory stimuli.

Journal: PloS one 20120101

Title: Arginine vasotocin regulation of interspecific cooperative behaviour in a cleaner fish.

Journal: PloS one 20120101

Title: Glutamate-vasopressin interactions and the neurobiology of anabolic steroid-induced offensive aggression.

Journal: Neuroscience 20110630

Title: Neuropeptide regulation of social behavior in a monogamous cichlid fish.

Journal: Physiology & behavior 20110301

Title: Selective blockade of oxytocin and vasopressin V(1a) receptors in anaesthetised rats: evidence that activation of oxytocin receptors rather than V(1a) receptors increases sodium excretion.

Journal: Nephron. Physiology 20110101

Title: Decreased susceptibility to salt-induced hypertension in subtotally nephrectomized mice lacking the vasopressin V1a receptor.

Journal: Cardiovascular research 20100701

Title: Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression.

Journal: Hormones and behavior 20100701

Title: Effects of arginine vasopressin on differentiation of cardiac fibroblasts into myofibroblasts.

Journal: Journal of cardiovascular pharmacology 20100501

Title: Arginine-vasopressin and the regulation of aggression in female Syrian hamsters (Mesocricetus auratus).

Journal: The European journal of neuroscience 20100501

Title: Central vasopressin V1a receptor activation is independently necessary for both partner preference formation and expression in socially monogamous male prairie voles.

Journal: Behavioral neuroscience 20100201

Title: Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats.

Journal: Neuropharmacology 20100101

Title: Individual behavioral and neuronal phenotypes for arginine vasotocin mediated courtship and aggression in a territorial teleost.

Journal: Brain, behavior and evolution 20100101

Title: Vasopressin is a major vasoconstrictor involved in hindlimb vascular responses to stimulation of adenosine A(1) receptors in the nucleus of the solitary tract.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Arginine-vasotocin influence on aggressive behavior and dominance in rainbow trout.

Journal: Physiology & behavior 20090302

Title: Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats.

Journal: Physiology & behavior 20080903

Title: Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080601

Title: Cardiovascular responses to noradrenaline microinjection in the ventrolateral periaqueductal gray of unanesthetized rats.

Journal: Journal of neuroscience research 20080215

Title: Chronic salt loading and cardiovascular-associated changes in experimental diabetes in rats.

Journal: Clinical and experimental pharmacology & physiology 20070701

Title: Role of vasopressin in rat distal colon function.

Journal: The Journal of physiology 20070115

Title: Effects of electrical stimulation of ventral septal area on firing rates of pyrogen-treated thermosensitive neurons in preoptic anterior hypothalamus from rabbits.

Journal: Life sciences 20070109

Title: New insights into neuropeptide modulation of aggression: field studies of arginine vasotocin in a territorial tropical damselfish.

Journal: Proceedings. Biological sciences 20061222

Title: Central action of increased osmolality to support blood pressure in deoxycorticosterone acetate-salt rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20061001

Title: Thermoregulatory role of inducible nitric oxide synthase in lipopolysaccharide-induced hypothermia.

Journal: Life sciences 20060905

Title: Interaction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balance.

Journal: Regulatory peptides 20051215

Title: Comparative cardiac effects of terlipressin, vasopressin, and norepinephrine on an isolated perfused rabbit heart.

Journal: Anesthesiology 20050101

Title: Blood flow measurements in rats using four color microspheres during blockade of different vasopressor systems.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050101

Title: Enhanced pressor response to centrally administered vasopressin in WKY rats on high sodium diet.

Journal: Acta neurobiologiae experimentalis 20050101

Title: Exogenous vasotocin alters aggression during agonistic exchanges in male Amargosa River pupfish (Cyprinodon nevadensis amargosae).

Journal: Hormones and behavior 20041201

Title: Neural responses to territorial challenge and nonsocial stress in male song sparrows: segregation, integration, and modulation by a vasopressin V1 antagonist.

Journal: Hormones and behavior 20041101

Title: Effect of photoperiod on vasopressin-induced aggression in Syrian hamsters.

Journal: Hormones and behavior 20041101

Title: Synergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats.

Journal: European journal of pharmacology 20040913

Title: Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus).

Journal: Behavioral neuroscience 20040601

Title: Effects of angiotensin and vasopressin V(1) receptors on water and sodium intake induced by injection of vasopressin into lateral septal area.

Journal: Regulatory peptides 20040515

Title: Multiple mechanisms of phenotype development in the bluehead wrasse.

Journal: Hormones and behavior 20040501

Title: Effects of central vasotocin and mesotocin manipulations on social behavior in male and female zebra finches.

Journal: Hormones and behavior 20040201

Title: Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin.

Journal: Brain research 20031212

Title: Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR.

Journal: Hypertension (Dallas, Tex. : 1979) 20031001

Title: Effects of V1 and angiotensin receptor subtypes of the paraventricular nucleus on the water intake induced by vasopressin injected into the lateral septal area.

Journal: Brain research bulletin 20030930

Title: Exendin-4, a GLP-1 receptor agonist, stimulates pituitary-adrenocortical axis in the rat: Investigations into the mechanism(s) underlying Ex4 effect.

Journal: International journal of molecular medicine 20030801

Title: Effects of arginine vasopressin on growth of rat cardiac fibroblasts: role of V1 receptor.

Journal: Journal of cardiovascular pharmacology 20030701

Title: Methylphenidate-induced motor activity in rats: modulation by melatonin and vasopressin.

Journal: Pharmacology, biochemistry, and behavior 20030401

Title: The influence of vasopressin on tonic activity of cardiovascular neurones in the ventrolateral medulla of the hypertensive rat.

Journal: Autonomic neuroscience : basic & clinical 20030328

Title: Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats.

Journal: American journal of physiology. Heart and circulatory physiology 20030301

Title: Vasopressin and oxytocin decrease excitatory amino acid release in adult rat supraoptic nucleus.

Journal: Journal of neuroendocrinology 20030201

Title: Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion.

Journal: The European journal of neuroscience 20020801

Title: The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene.

Journal: Circulation research 20020111

Title: Role of vasopressin in 24-hour blood pressure regulation in diabetic patients with autonomic neuropathy.

Journal: American journal of hypertension 20020101

Title: Endogenous endothelin and vasopressin support blood pressure during epidural anesthesia in conscious dogs.

Journal: Anesthesia and analgesia 20011201

Title: Neural and hormonal control of arterial pressure during cold exposure in unanesthetized week-old rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011101

Title: Electrophysiological evidence for vasopressin V(1) receptors on neonatal motoneurons, premotor and other ventral horn neurons.

Journal: Journal of neurophysiology 20010901

Title: Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster).

Journal: Behavioral neuroscience 20010801

Title: Central vasopressin administration regulates the onset of facultative paternal behavior in microtus pennsylvanicus (meadow voles).

Journal: Hormones and behavior 20010601

Title: Role of endothelin and vasopressin in DOCA-salt hypertension.

Journal: British journal of pharmacology 20010401

Title: Arginine vasopressin inhibits apoptosis of rat glomerular mesangial cells via V1a receptors.

Journal: Life sciences 20010216

Title: Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats.

Journal: Hypertension (Dallas, Tex. : 1979) 19940601

Title: Endogenous vasopressin and renin-angiotensin systems support blood pressure after epidural block in humans.

Journal: Anesthesiology 19940501

Title: Contribution of vasopressin in dexamethasone-induced hypertension in rats.

Journal: Hypertension (Dallas, Tex. : 1979) 19880201

Title: Selective cardiovascular and neuroendocrine effects of a kappa-opioid agonist in the nucleus tractus solitarii of rats.

Journal: The Journal of physiology 19851001

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Tags:73168-24-8 Molecular Formula|73168-24-8 MDL|73168-24-8 SMILES|73168-24-8 3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2