73536-69-3,MFCD01751431
Catalog No.:AA00ICC4

73536-69-3 | Bifendatatum

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%(HPLC)
in stock  
$24.00   $17.00
- +
5g
98%(HPLC)
in stock  
$34.00   $24.00
- +
25g
97%
in stock  
$75.00   $53.00
- +
100g
97%
in stock  
$202.00 $142.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ICC4
Chemical Name:
Bifendatatum
CAS Number:
73536-69-3
Molecular Formula:
C20H18O10
Molecular Weight:
418.3509
MDL Number:
MFCD01751431
SMILES:
COC(=O)c1cc(OC)c2c(c1c1c(cc(c3c1OCO3)OC)C(=O)OC)OCO2
Properties
Computed Properties
 
Complexity:
587  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECH-CN106749157,2017,ALocationinpatent:Paragraph0021;0022;0023;0024

[2]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]

[3]Gu,Xiaoke;Ren,Zhiguang;Tang,Xiaobo;Peng,Hui;Ma,Yuanfang;Lai,Yisheng;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistry,2012,vol.20,#8,p.2540-2548]

[4]CurrentPatentAssignee:BEIJINGYUANYANMEDICINETECH-CN107141278,2017,A

[5]CurrentPatentAssignee:BEIJINGYUANYANMEDICINETECH-CN107141278,2017,A

[6]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586425,2018,A

Literature

Title: Protective effects of geniposide against Tripterygium glycosides (TG)-induced liver injury and its mechanisms.

Journal: The Journal of toxicological sciences 20160201

Title: Hepatoprotective effects of Mimic of Manganese superoxide dismutase against carbon tetrachloride-induced hepatic injury.

Journal: International immunopharmacology 20140901

Title: Efficacy and tolerability of diphenyl-dimethyl-dicarboxylate plus garlic oil in patients with chronic hepatitis.

Journal: International journal of clinical pharmacology and therapeutics 20121101

Title: Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors.

Journal: European journal of medicinal chemistry 20120501

Title: Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors.

Journal: Bioorganic & medicinal chemistry 20120415

Title: Cytochrome P450 dysregulations in thioacetamide-induced liver cirrhosis in rats and the counteracting effects of hepatoprotective agents.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation.

Journal: International journal of pharmaceutics 20120117

Title: Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†).

Journal: Pharmaceutical biology 20120101

Title: Synthesis and biological evaluation of novel dimethyl[1,1'-biphenyl]-2,2'-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.

Journal: European journal of medicinal chemistry 20111201

Title: Thioacetamide intoxication triggers transcriptional up-regulation but enzyme inactivation of UDP-glucuronosyltransferases.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20111001

Title: Antiapoptotic effect of DDB against hepatic ischemia-reperfusion injury.

Journal: The Journal of toxicological sciences 20110401

Title: Hepatoprotection in a rat model of acute liver damage through inhibition of CY2E1 activity by total alkaloids extracted from Rubus alceifolius Poir.

Journal: International journal of toxicology 20110301

Title: Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.

Journal: Journal of ethnopharmacology 20100915

Title: Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni.

Journal: Memorias do Instituto Oswaldo Cruz 20100901

Title: Electrochemical treatment of aqueous wastes containing pyrogallol by BDD-anodic oxidation.

Journal: Journal of environmental management 20090101

Title: Self-nanoemulsifying drug delivery system for enhanced bioavailability and improved hepatoprotective activity of biphenyl dimethyl dicarboxylate.

Journal: Current drug delivery 20080701

Title: Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070601

Title: Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats.

Journal: TheScientificWorldJournal 20070101

Title: Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15.

Journal: Archives of pharmacal research 20060501

Title: Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector.

Journal: Journal of chromatography. A 20060303

Title: Chemopreventive effect of dimethyl dicarboxylate biphenyl on malignant transformation of WB-F344 rat liver epithelial cells.

Journal: Acta pharmacologica Sinica 20051101

Title: Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20050801

Title: The potential anti-hBV effect of amantadine in combination with ursodeoxycholic acid and biphenyl dimethyl dicarboxylate in hepG2 2.2.15 cells.

Journal: Archives of pharmacal research 20050401

Title: DDB treatment of patients with chronic hepatitis.

Journal: Hepatology (Baltimore, Md.) 20040601

Title: Characterization of novel nucleoside analogs by electrospray ionization mass spectra.

Journal: European journal of mass spectrometry (Chichester, England) 20040101

Title: Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins.

Journal: Free radical biology & medicine 20030815

Title: Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20030801

Title: A polymeric micellar carrier for the solubilization of biphenyl dimethyl dicarboxylate.

Journal: Archives of pharmacal research 20030201

Title: Effects of dimethyl diphenyl bicarboxylate on the metabolism and hepatotoxicity of aflatoxin B1 in rats.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20021001

Title: Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver.

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20020101

Title: Characterization of the selectivity and mechanism of cytochrome P450 inhibition by dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20011201

Title: [Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010701

Title: Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20010129

Title: Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues.

Journal: Bioorganic & medicinal chemistry 19970801

Title: Anti-AIDS (acquired immune deficiency syndrome) agents. 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents.

Journal: Journal of medicinal chemistry 19950804

Title: Cui S, et al. [Anti-HBV efficacy of bifendate in treatment of chronic hepatitis B, a primary study Zhonghua Yi Xue Za Zhi. 2002 Apr 25;82(8):538-40.

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Related Products of 73536-69-3
Tags:73536-69-3 Molecular Formula|73536-69-3 MDL|73536-69-3 SMILES|73536-69-3 Bifendatatum
Catalog No.: AA00ICC4
73536-69-3,MFCD01751431
73536-69-3 | Bifendatatum
Pack Size: 1g
Purity: 98%(HPLC)
in stock
$24.00 $17.00
Pack Size: 5g
Purity: 98%(HPLC)
in stock
$34.00 $24.00
Pack Size: 25g
Purity: 97%
in stock
$75.00 $53.00
Pack Size: 100g
Purity: 97%
in stock
$202.00 $142.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00ICC4
Chemical Name: Bifendatatum
CAS Number: 73536-69-3
Molecular Formula: C20H18O10
Molecular Weight: 418.3509
MDL Number: MFCD01751431
SMILES: COC(=O)c1cc(OC)c2c(c1c1c(cc(c3c1OCO3)OC)C(=O)OC)OCO2
Properties
Complexity: 587  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 10  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.8  
Downstream Synthesis Route
73536-69-3    118159-48-1 

[1]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECH-CN106749157,2017,ALocationinpatent:Paragraph0021;0022;0023;0024

[2]Tang,Xiaobo;Gu,Xiaoke;Ren,Zhiguang;Ma,Yuanfang;Lai,Yisheng;Peng,Hui;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistryLetters,2012,vol.22,#8,p.2675-2680]

[3]Gu,Xiaoke;Ren,Zhiguang;Tang,Xiaobo;Peng,Hui;Ma,Yuanfang;Lai,Yisheng;Peng,Sixun;Zhang,Yihua[BioorganicandMedicinalChemistry,2012,vol.20,#8,p.2540-2548]

[4]CurrentPatentAssignee:BEIJINGYUANYANMEDICINETECH-CN107141278,2017,A

[5]CurrentPatentAssignee:BEIJINGYUANYANMEDICINETECH-CN107141278,2017,A

[6]CurrentPatentAssignee:XUZHOUMEDICALUNIVERSITY-CN108586425,2018,A

Literature fold

Title: Protective effects of geniposide against Tripterygium glycosides (TG)-induced liver injury and its mechanisms.

Journal: The Journal of toxicological sciences20160201

Title: Hepatoprotective effects of Mimic of Manganese superoxide dismutase against carbon tetrachloride-induced hepatic injury.

Journal: International immunopharmacology20140901

Title: Efficacy and tolerability of diphenyl-dimethyl-dicarboxylate plus garlic oil in patients with chronic hepatitis.

Journal: International journal of clinical pharmacology and therapeutics20121101

Title: Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors.

Journal: European journal of medicinal chemistry20120501

Title: Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors.

Journal: Bioorganic & medicinal chemistry20120415

Title: Cytochrome P450 dysregulations in thioacetamide-induced liver cirrhosis in rats and the counteracting effects of hepatoprotective agents.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120401

Title: Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation.

Journal: International journal of pharmaceutics20120117

Title: Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†).

Journal: Pharmaceutical biology20120101

Title: Synthesis and biological evaluation of novel dimethyl[1,1'-biphenyl]-2,2'-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.

Journal: European journal of medicinal chemistry20111201

Title: Thioacetamide intoxication triggers transcriptional up-regulation but enzyme inactivation of UDP-glucuronosyltransferases.

Journal: Drug metabolism and disposition: the biological fate of chemicals20111001

Title: Antiapoptotic effect of DDB against hepatic ischemia-reperfusion injury.

Journal: The Journal of toxicological sciences20110401

Title: Hepatoprotection in a rat model of acute liver damage through inhibition of CY2E1 activity by total alkaloids extracted from Rubus alceifolius Poir.

Journal: International journal of toxicology20110301

Title: Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.

Journal: Journal of ethnopharmacology20100915

Title: Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni.

Journal: Memorias do Instituto Oswaldo Cruz20100901

Title: Electrochemical treatment of aqueous wastes containing pyrogallol by BDD-anodic oxidation.

Journal: Journal of environmental management20090101

Title: Self-nanoemulsifying drug delivery system for enhanced bioavailability and improved hepatoprotective activity of biphenyl dimethyl dicarboxylate.

Journal: Current drug delivery20080701

Title: Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20070601

Title: Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats.

Journal: TheScientificWorldJournal20070101

Title: Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15.

Journal: Archives of pharmacal research20060501

Title: Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector.

Journal: Journal of chromatography. A20060303

Title: Chemopreventive effect of dimethyl dicarboxylate biphenyl on malignant transformation of WB-F344 rat liver epithelial cells.

Journal: Acta pharmacologica Sinica20051101

Title: Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice.

Journal: Liver international : official journal of the International Association for the Study of the Liver20050801

Title: The potential anti-hBV effect of amantadine in combination with ursodeoxycholic acid and biphenyl dimethyl dicarboxylate in hepG2 2.2.15 cells.

Journal: Archives of pharmacal research20050401

Title: DDB treatment of patients with chronic hepatitis.

Journal: Hepatology (Baltimore, Md.)20040601

Title: Characterization of novel nucleoside analogs by electrospray ionization mass spectra.

Journal: European journal of mass spectrometry (Chichester, England)20040101

Title: Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins.

Journal: Free radical biology & medicine20030815

Title: Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury.

Journal: Liver international : official journal of the International Association for the Study of the Liver20030801

Title: A polymeric micellar carrier for the solubilization of biphenyl dimethyl dicarboxylate.

Journal: Archives of pharmacal research20030201

Title: Effects of dimethyl diphenyl bicarboxylate on the metabolism and hepatotoxicity of aflatoxin B1 in rats.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20021001

Title: Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver.

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit20020101

Title: Characterization of the selectivity and mechanism of cytochrome P450 inhibition by dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate.

Journal: Drug metabolism and disposition: the biological fate of chemicals20011201

Title: [Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20010701

Title: Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery.

Journal: Journal of controlled release : official journal of the Controlled Release Society20010129

Title: Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues.

Journal: Bioorganic & medicinal chemistry19970801

Title: Anti-AIDS (acquired immune deficiency syndrome) agents. 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents.

Journal: Journal of medicinal chemistry19950804

Title: Cui S, et al. [Anti-HBV efficacy of bifendate in treatment of chronic hepatitis B, a primary study Zhonghua Yi Xue Za Zhi. 2002 Apr 25;82(8):538-40.

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