[1]JournalofMedicinalChemistry,2011,vol.54,p.4998-5012
[1]Locationinpatent:experimentalpartMiwa,Kazuhiro;Hitaka,Takenori;Imada,Takashi;Sasaki,Satoshi;Yoshimatsu,Mie;Kusaka,Masami;Tanaka,Akira;Nakata,Daisuke;Furuya,Shuichi;Endo,Satoshi;Hamamura,Kazumasa;Kitazaki,Tomoyuki[JournalofMedicinalChemistry,2011,vol.54,#14,p.4998-5012]
[1]CurrentPatentAssignee:SICHUANDINNOVATIONPHARMACEUTICAL-CN110194776,2019,ALocationinpatent:Paragraph0059;0062;0081-0085
[2]CurrentPatentAssignee:CHINANATIONALPHARMACEUTICALGROUPCORPORATION-CN115073491,2022,ALocationinpatent:Paragraph0151-0153
[1]CurrentPatentAssignee:SICHUANDINNOVATIONPHARMACEUTICAL-CN110194776,2019,A
[2]CurrentPatentAssignee:SHENZHENLANGRUNINVESTMENTCO.,LTD.-CN111423452,2020,A
[3]CurrentPatentAssignee:BEIJINGHMYMEDICALTECH-CN113135934,2021,A
[4]CurrentPatentAssignee:CHINANATIONALPHARMACEUTICALGROUPCORPORATION-CN115073490,2022,A
[5]CurrentPatentAssignee:CHINANATIONALPHARMACEUTICALGROUPCORPORATION-CN115073491,2022,A
[6]CurrentPatentAssignee:CHINANATIONALPHARMACEUTICALGROUPCORPORATION-CN115626933,2023,A
[7]CurrentPatentAssignee:CHINANATIONALPHARMACEUTICALGROUPCORPORATION-CN115504994,2022,A
[1]CurrentPatentAssignee:SHENZHENLANGRUNINVESTMENTCO.,LTD.-CN111333633,2020,ALocationinpatent:Paragraph0134-0140
Title: Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.
Journal: Journal of medicinal chemistry 20110728
Title: Kazuhiro Miwa, et al. Discovery of 1-{4--(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno,3-dpyrimidin-6-ylphenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. doi/10.1021/jm200216q
Title: Daisuke Nakata, et al. Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice. Eur J Pharmacol. 2014 Jan 15;723:167-74.
