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742-20-1,MFCD00865825
Catalog No.:AA01CB7H

742-20-1 | 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide

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250mg
98%
in stock  
$33.00   $23.00
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1g
98%
in stock  
$83.00   $58.00
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5g
98%
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$386.00   $270.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01CB7H
Chemical Name:
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
CAS Number:
742-20-1
Molecular Formula:
C13H18ClN3O4S2
Molecular Weight:
379.8827
MDL Number:
MFCD00865825
SMILES:
Clc1cc2NC(CC3CCCC3)NS(=O)(=O)c2cc1S(=O)(=O)N
NSC Number:
107679
Properties
Computed Properties
 
Complexity:
637  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.3  

Downstream Synthesis Route

[1]Whitehead,C.W.etal.[JournalofOrganicChemistry,1961,vol.26,p.2814-2818]

[1]Whitehead,C.W.etal.[JournalofOrganicChemistry,1961,vol.26,p.2814-2818]

[1]Blaschke;Maibaum[JournalofPharmaceuticalSciences,1985,vol.74,#4,p.438-442]

742-20-1    1087345-33-2   
CASUnavailable 

[1]Onishi,Takafumi;Ueda,Takunori;Yoshida,Kenichi;Uosaki,Kosuke;Ando,Hiroyuki;Hamasaki,Ryota;Ohnishi,Atsushi[Chirality,2022,vol.34,#7,p.925-940]

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The antihypertensive and metabolic effects of low and conventional dose cyclopenthiazide in type II diabetics with hypertension.

Journal: The Quarterly journal of medicine 19911101

Title: Low-dose cyclopenthiazide in the treatment of hypertension: a one-year community-based study.

Journal: The Quarterly journal of medicine 19910201

Title: Enalapril-related cholestatic jaundice.

Journal: Journal of the Royal Society of Medicine 19900401

Title: Is nifedipine a suitable first-line treatment for essential hypertension in general practice?

Journal: European heart journal 19871101

Title: Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders.

Journal: Drugs 19870401

Title: Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.

Journal: British heart journal 19850901

Title: Inappropriate antihypertensive therapy in the elderly.

Journal: Lancet (London, England) 19761218

Title: Effect of long-term diuretic treatment on body-potassium in heart-disease.

Journal: Lancet (London, England) 19761113

Title: Letter: Paradoxical effect of pindolol.

Journal: British medical journal 19750719

Title: Bräunlich H. Postnatal development of kidney function in rats receiving thyroid hormones. Exp Clin Endocrinol. 1984 May;83(3):243-50.

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SDS
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Tags:742-20-1 Molecular Formula|742-20-1 MDL|742-20-1 SMILES|742-20-1 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide