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754240-09-0,MFCD11114384
Catalog No.:AA005BFX

754240-09-0 | EHT 1864

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$28.00   $19.00
- +
5mg
98%
in stock  
$67.00   $47.00
- +
10mg
98%
in stock  
$101.00   $71.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA005BFX
Chemical Name:
EHT 1864
CAS Number:
754240-09-0
Molecular Formula:
C25H29Cl2F3N2O4S
Molecular Weight:
581.4750
MDL Number:
MFCD11114384
SMILES:
O=c1cc(occ1OCCCCCSc1ccnc2c1ccc(c2)C(F)(F)F)CN1CCOCC1.Cl.Cl
Properties
Properties
 
Form:
Solid  
MP:
>195°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
770  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route
7647-01-0    152368-17-7   
5-(5-7-(trifluoromethyl)quinolin-4-ylsulfanyl}pentyl)oxy-2-(morpholin-4-yl)methyl-4H-pyran-4-onedihydrochloride 

[1]CurrentPatentAssignee:DIAXONHITGROUP-WO2004/76445,2004,A2Locationinpatent:Page101;102

[1]CurrentPatentAssignee:DIAXONHITGROUP-US2007/27146,2007,A1Locationinpatent:Page/Pagecolumn11

[1]CurrentPatentAssignee:DIAXONHITGROUP-WO2004/76445,2004,A2

[1]CurrentPatentAssignee:DIAXONHITGROUP-WO2004/76445,2004,A2

Literature

Title: The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.

Journal: The Journal of biological chemistry 20161014

Title: Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.

Journal: Journal of neuro-oncology 20110801

Title: Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.

Journal: Endocrine-related cancer 20110401

Title: Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells.

Journal: Circulation research 20100430

Title: RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

Journal: The Journal of biological chemistry 20051111

Title: Crystalline aspartate aminotransferase from Pseudomonas striata.

Journal: FEBS letters 19760101

Title: Desire L, et al. RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. J Biol Chem. 2005 Nov 11;280(45):37516-25.

Title: Shutes A, et al. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78.

Title: Onesto C, et al. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 2008;439:111-29.

Quotation Request
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SDS
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Tags:754240-09-0 Molecular Formula|754240-09-0 MDL|754240-09-0 SMILES|754240-09-0 EHT 1864
Catalog No.: AA005BFX
754240-09-0,MFCD11114384
754240-09-0 | EHT 1864
Pack Size： 1mg
Purity： 98%
in stock
$28.00 $19.00
Pack Size： 5mg
Purity： 98%
in stock
$67.00 $47.00
Pack Size： 10mg
Purity： 98%
in stock
$101.00 $71.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA005BFX
Chemical Name: EHT 1864
CAS Number: 754240-09-0
Molecular Formula: C25H29Cl2F3N2O4S
Molecular Weight: 581.4750
MDL Number: MFCD11114384
SMILES: O=c1cc(occ1OCCCCCSc1ccnc2c1ccc(c2)C(F)(F)F)CN1CCOCC1.Cl.Cl
Properties
Form: Solid  
MP: >195°C (dec.)  
Storage: Inert atmosphere;2-8℃;  
Complexity: 770  
Covalently-Bonded Unit Count: 3  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 37  
Hydrogen Bond Acceptor Count: 10  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 10  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
7647-01-0    152368-17-7   
5-(5-7-(trifluoromethyl)quinolin-4-ylsulfanyl}pentyl)oxy-2-(morpholin-4-yl)methyl-4H-pyran-4-onedihydrochloride 

[1]CurrentPatentAssignee:DIAXONHITGROUP-WO2004/76445,2004,A2Locationinpatent:Page101;102

754239-64-0    754240-09-0 

[1]CurrentPatentAssignee:DIAXONHITGROUP-US2007/27146,2007,A1Locationinpatent:Page/Pagecolumn11

501-30-4    754240-09-0 

[1]CurrentPatentAssignee:DIAXONHITGROUP-WO2004/76445,2004,A2

40838-28-6    754240-09-0 

[1]CurrentPatentAssignee:DIAXONHITGROUP-WO2004/76445,2004,A2

Literature fold

Title: The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.

Journal: The Journal of biological chemistry20161014

Title: Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.

Journal: Journal of neuro-oncology20110801

Title: Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.

Journal: Endocrine-related cancer20110401

Title: Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells.

Journal: Circulation research20100430

Title: RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

Journal: The Journal of biological chemistry20051111

Title: Crystalline aspartate aminotransferase from Pseudomonas striata.

Journal: FEBS letters19760101

Title: Desire L, et al. RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. J Biol Chem. 2005 Nov 11;280(45):37516-25.

Title: Shutes A, et al. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78.

Title: Onesto C, et al. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 2008;439:111-29.

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