Home Other Building Blocks 755038-65-4
755038-65-4,MFCD20926414
Catalog No.:AA00G3NO

755038-65-4 | Volasertib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$22.00   $15.00
- +
10mg
98%
in stock  
$28.00   $20.00
- +
100mg
98%
in stock  
$211.00   $148.00
- +
250mg
98%
in stock  
$411.00   $288.00
- +
1g
98%
in stock  
$1,208.00   $846.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3NO
Chemical Name:
Volasertib
CAS Number:
755038-65-4
Molecular Formula:
C34H50N8O3
Molecular Weight:
618.8126
MDL Number:
MFCD20926414
SMILES:
CC[C@H]1N(C(C)C)c2nc(ncc2N(C1=O)C)Nc1ccc(cc1OC)C(=O)N[C@@H]1CC[C@H](CC1)N1CCN(CC1)CC1CC1
Properties
Computed Properties
 
Complexity:
996  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
4.6  

Downstream Synthesis Route
CASUnavailable 
  755038-65-4 

[1]CurrentPatentAssignee:ONCOHEROESBIOSCIENCESINC-US2012/238754,2012,A1

[1]CurrentPatentAssignee:ONCOHEROESBIOSCIENCESINC-US2012/238754,2012,A1

[1]CurrentPatentAssignee:ONCOHEROESBIOSCIENCESINC-US2012/238754,2012,A1

877676-50-1    882660-39-1   
Volasertib 

[1]Patent:US2012/238754,2012,A1.Locationinpatent:Paragraph0113;0114

Literature

Title: BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1.

Journal: Theranostics 20160101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20121215

Title: Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology.

Journal: The oncologist 20090601

Title: BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090501

Title: Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.

Journal: Molecular biology of the cell 20071001

Title: Polo-like kinases and the orchestration of cell division.

Journal: Nature reviews. Molecular cell biology 20040601

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SDS
Tags:755038-65-4 Molecular Formula|755038-65-4 MDL|755038-65-4 SMILES|755038-65-4 Volasertib